Donor must be medically, socially, and psychologically fit to donate |
The patient must lack clinically significant antibodies against donor HLA molecules |
- Specifically, complement dependent cytotoxicity and flow cytometric crossmatch assays must be negative, and the mean fluorescence intensity (MFI) of any anti-donor HLA antibody by solid phase immunoassay should be <3000
|
Donor age <40 years preferred over donor age ≥40 years |
No major ABO incompatibility between donor and recipient |
- Major ABO incompatibilities include:
- Recipient blood type O: Donor type A, B, or AB
- Recipient blood type A: Donor blood type B or AB
- Recipient blood type B: Donor blood type A or AB
- Recipient blood type AB: No major ABO incompatibilities
|
Matched CMV IgG serologic status between donor and recipient |
- For a recipient who is CMV IgG negative, use a CMV IgG negative donor
- For a recipient who is CMV IgG positive, use a CMV IgG positive donor
|
Use an ABO compatible donor over a minor ABO incompatible donor |
- ABO compatible transplants are O→O, A→A, B→B, or AB→AB
|
Other donor characteristics (in no order of priority) |
- Donor age ≥18 preferred over donor <18
- Among donors ≥18 years, prefer younger and lighter donors
- For male recipients, male donors are preferred over nulliparous female donors who are preferred over multiparous female donors
|