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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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HLA-haploidentical donor selection criteria (in decreasing order of priority)

HLA-haploidentical donor selection criteria (in decreasing order of priority)
Donor must be medically, socially, and psychologically fit to donate
The patient must lack clinically significant antibodies against donor HLA molecules
  • Specifically, complement dependent cytotoxicity and flow cytometric crossmatch assays must be negative, and the mean fluorescence intensity (MFI) of any anti-donor HLA antibody by solid phase immunoassay should be <3000
Donor age <40 years preferred over donor age ≥40 years
No major ABO incompatibility between donor and recipient
  • Major ABO incompatibilities include:
    • Recipient blood type O: Donor type A, B, or AB
    • Recipient blood type A: Donor blood type B or AB
    • Recipient blood type B: Donor blood type A or AB
    • Recipient blood type AB: No major ABO incompatibilities
Matched CMV IgG serologic status between donor and recipient
  • For a recipient who is CMV IgG negative, use a CMV IgG negative donor
  • For a recipient who is CMV IgG positive, use a CMV IgG positive donor
Use an ABO compatible donor over a minor ABO incompatible donor
  • ABO compatible transplants are O→O, A→A, B→B, or AB→AB
Other donor characteristics (in no order of priority)
  • Donor age ≥18 preferred over donor <18
  • Among donors ≥18 years, prefer younger and lighter donors
  • For male recipients, male donors are preferred over nulliparous female donors who are preferred over multiparous female donors
Graphic 99884 Version 2.0

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