Toxicity in acute acquired methemoglobinemia

Methemoglobin level	Symptoms*
0 to 3 percent	Normal range for adults (mean: 1 percent)
3 to 12 percent	Minimal level; may or may not be associated with detectable cyanosis or skin discoloration
13 to 20 percent	Usually asymptomatic unless preexisting condition present
20 to 50 percent	Mild to moderate symptoms of hypoxemia^¶
50 to 70 percent	Severe, life-threatening symptoms of hypoxemia^Δ
>70 percent	Usually fatal

Refer to UpToDate for additional information.

* Preexisting conditions such as anemia, heart disease, and lung disease may exacerbate toxicity.
¶ Symptoms of mild to moderate toxicity include lightheadedness, fatigue, tachycardia, dyspnea, and lethargy.
Δ Symptoms of severe toxicity include respiratory depression, altered sensorium, coma, shock, and seizures.

Courtesy of Josef T Prchal, MD.

Graphic 99739 Version 4.0

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Toxicity in acute acquired methemoglobinemia