Clinical research criteria for probable sporadic CBD | Clinical criteria for possible CBD¶ | |
Presentation | Insidious onset and gradual progression | Insidious onset and gradual progression |
Minimum duration of symptoms, years | 1 | 1 |
Age at onset, years | ≥50 | No minimum |
Family history (two or more relatives) | Exclusion | Permitted |
Permitted phenotypes |
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|
Genetic mutation affecting tau (eg, MAPT) | Exclusion | Permitted |
CBD: corticobasal degeneration; CBS: corticobasal syndrome; FBS: frontal behavioral-spatial syndrome; MAPT: microtubule-associated protein tau; NAV: nonfluent/agrammatic variant of primary progressive aphasia; PSPS: progressive supranuclear palsy syndrome.
* Exclusion criteria for both clinical research criteria for probable sporadic CBD and possible CBD:¶ Possible CBD emphasizes clinical presentations consistent with CBD but ones that may also overlap with other tau-based pathologies.
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