Gastrointestinal |
Increased losses (diarrhea, vomiting, nasogastric drainage) |
Decreased intake (anorexia, bulimia) |
Increased potassium intracellular uptake |
Alkalosis |
Increased insulin activity |
Beta adrenergic agents (eg, albuterol, epinephrine, dopamine) |
Periodic paralysis: - Genetic etiology
- Hyperthyroidism
|
Other drugs: - Barium
- Antipsychotic drugs
- Chloroquine
|
Increased urinary losses |
Increased distal delivery of sodium to distal nephron: - Diuretics
- Osmotic diuretics (mannitol, hyperglycemia)
- Nonreabsorbed anions (elevated serum bicarbonate level)
- Tubular injury (cisplatin)
|
Types I and II renal tubular acidosis |
Increased mineralocorticoid activity: - Hyperaldosteronism due to hypovolemia
- Glucocorticoid remediable aldosteronism
- Apparent mineralocorticoid excess
- Rare forms of congenital adrenal hyperplasia (17-alpha-hydroxylase deficiency and 11-beta-hydroxylase deficiency)
|
Tubulopathies (Bartter syndrome, Gitelman syndrome) |
Amphotericin |
Enhanced sodium reabsorption (Liddle syndrome) |
Increased skin loss |
Cystic fibrosis |