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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Selected studies reporting outcome of patients with surgically managed neuroendocrine liver metastases

Selected studies reporting outcome of patients with surgically managed neuroendocrine liver metastases
Study Time period of study

Number of patients

undergoing surgery

 Fraction undergoing combined modality therapy (resection + ablation) (%) Symptom control (%) 5-year OS (%) 5-year recurrence rates (%) 10-year recurrence rates (%)
Chamberlain (2000)[1] 1992-1998  34 - 54 76  - - 
Elias (2003)[2] 1985-2000 47 -  - 71 

5-year liver recurrence

54

10-year liver recurrence

75
Sarmiento (2003)[3] 1977-1998 170 - 96 61

84

 94
Osborne (2006)[4] 2000-2004 61 28 93

Mean

43 months

 - -
Ahmed (2009)[5] 1973-2007 50 - - 74 - -
Glazer (2010)[6] 1978-2009 144 16 - 77 - -
Mayo (2010)[7] 1985-2010 339 20 - 74

94

 99
Saxena (2011)[8] 1992-2009 74 51 - 63

79

 86 (7 years)
Gaujoux (2012)[9] 1992-2009 36 - 60 (5-year symptom-free survival) 69

87

 -
Bagante (2017)[10] 1990-2014  376  22 -  - 54   - 
OS: overall survival.
References:
  1. Chamberlain RS, Canes D, Brown KT, et al. Hepatic neuroendocrine metastases: does intervention alter outcomes? J Am Coll Surg 2000; 190:432.
  2. Elias D, Lasser P, Ducreux M, et al. Liver resection (and associated extrahepatic resections) for metastatic well-differentiated endocrine tumors: a 15-year single center prospective study. Surgery 2003; 133:375.
  3. Sarmiento JM, HeywoodG, Rubin J, et al. Surgical treatment of neuroendocrine metastases to the liver: a plea for resection to increase survival. J Am Coll Surg 2003; 197:29.
  4. Osborne DA, Zervos EE, Strosberg J, et al. Improved outcome with cytoreduction versus embolization for symptomatic hepatic metastases of carcinoid and neuroendocrine tumors. Ann Surg Oncol 2006; 13:572.
  5. Ahmed A, Turner G, King B, et al. Midgut neuroendocrine tumours with liver metastases: results of the UKINETS study. Endocr Relat Cancer 2009; 16:885.
  6. Glazer ES, Tseng JF, Al-Refaie W, et al. Long-term survival after surgical management of neuroendocrine hepatic metastases. HPB (Oxford) 2010; 12:427.
  7. Mayo SC, de Jong MC, Pulitano C, et al. Surgical management of hepatic neuroendocrine tumor metastasis: results from an international multi-institutional analysis. Ann Surg Oncol 2010; 17:3129.
  8. Saxena A, Chua TC, Sarkar A, et al., Progression and survival results after radical hepatic metastasectomy of indolent advanced neuroendocrine neoplasms (NENs) supports an aggressive surgical approach. Surgery 2011; 149:209.
  9. Gaujoux S, Gonen M, Tang L, et al. Synchronous resection of primary and liver metastases for neuroendocrine tumors. Ann Surg Oncol 2012; 19:4270.
  10. Bagante F, Spolverato G, Merath K, et al. Neuroendocrine liver metastases: The chance to be cured after liver surgery. J Surg Oncol 2017; 115:679.
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