Clinical scenario | Preferred study |
Need for comprehensive whole-body cancer staging | Integrated FDG-PET/CT; bone scan if PET not done |
Multiple myeloma (lytic bone disease) | Whole-body skeletal plain radiographic survey or Low-dose whole-body CT |
Multiple myeloma (sclerotic bone lesions [eg, POEMS syndrome]) | Nuclear medicine bone scan |
Rapidly progressive metastases associated with minimal reactive bone formation | Integrated FDG-PET/CT |
Ewing sarcoma family of tumors with primary lytic tumor | Integrated FDG-PET/CT |
All others | Nuclear medicine bone scan |
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