Histologic key features of different forms of microscopic colitis

	LC	CC	MCi or MCnos
IELs	>20 IELs	Normal to slightly increased	5-20 IELs
Subepithelial collagen layer	Normal to slightly thickened	>10 micrometers	5-10 micrometers
Surface epithelium damage	+	++	(+)
Lamina propria inflammation	++	++	+/++

CC: collagenous colitis; IELs: intraepithelial lymphocytes; LC: lymphocytic colitis; MCi: microscopic colitis incomplete; MCnos: microscopic colitis not otherwise specified.

Reproduced from: Münch A, Langner C. Microscopic colitis: Clinical and pathologic perspectives. Clin Gastroenterol Hepatol 2015; 13:228. Table used with the permission of Elsevier Inc. All rights reserved.

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Histologic key features of different forms of microscopic colitis