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Tamsulosin: Drug information

Tamsulosin: Drug information
(For additional information see "Tamsulosin: Patient drug information" and see "Tamsulosin: Pediatric drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Flomax
Brand Names: Canada
  • APO-Tamsulosin CR;
  • Flomax CR;
  • RATIO-Tamsulosin [DSC];
  • SANDOZ Tamsulosin;
  • SANDOZ Tamsulosin CR;
  • TEVA-Tamsulosin CR;
  • TEVA-Tamsulosin [DSC]
Pharmacologic Category
  • Alpha 1 Blocker
Dosing: Adult
Benign prostatic hyperplasia

Benign prostatic hyperplasia (monotherapy or combination therapy):

Note : In patients with moderate to severe predominant storage lower urinary tract symptoms, use in combination with beta-3 agonist or anticholinergic agent. In patients with a significantly enlarged prostate (prostate volume >30 mL, prostate-specific antigen >1.5 ng/mL, or palpable prostate enlargement on digital rectal exam), use in combination with 5-alpha reductase inhibitor (Ref).

Oral:

Capsule: Initial and maintenance: 0.4 mg once daily. If response is inadequate after 2 to 4 weeks, may increase to 0.8 mg once daily. If therapy is discontinued or interrupted for several days, restart with 0.4 mg once daily.

Controlled-release tablet [Canadian product]: 0.4 mg once daily.

Chronic prostatitis/chronic pelvic pain syndrome in males

Chronic prostatitis/chronic pelvic pain syndrome in males (off-label use): Oral: Initial: 0.4 mg once daily for 6 weeks as part of an appropriate combination regimen (Ref). If response to initial therapy is inadequate, referral to a urologist is recommended (Ref).

Lower urinary tract symptoms in males

Lower urinary tract symptoms in males (off-label use): Bladder outlet obstruction and low postvoid residual: Oral: Initial: 0.4 mg once daily; may combine with an anticholinergic agent if symptoms of overactive bladder persist (Ref).

Ureteral stent-related urinary symptoms, treatment

Ureteral stent-related urinary symptoms, treatment (off-label use): Oral: 0.4 mg once daily; treatment was initiated following stent placement and duration of therapy in trials ranged from 1 to 6 weeks (Ref); may also be given in combination with an anticholinergic agent (Ref).

Ureteral stone(s) expulsion

Ureteral stone(s) expulsion (off-label use):

Note: Consider for use in patients with ureteral stones >5 and ≤10 mm (Ref). Although most evidence exists for distal ureteral stones, given the low side effect profile of alpha-blockers, may consider use in patients with stones in any location of ureter (Ref).

Oral: 0.4 mg once daily until stone passage or for up to 4 weeks (Ref).

Adjunctive therapy following shock wave lithotripsy to facilitate clearance of residual stones: Oral: 0.4 mg once daily; initiate therapy immediately after extracorporeal shock wave lithotripsy (Ref).

Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Dosing: Kidney Impairment: Adult

The renal dosing recommendations are based upon the best available evidence and clinical expertise. Senior Editorial Team: Bruce Mueller, PharmD, FCCP, FASN, FNKF; Jason Roberts, PhD, BPharm (Hons), B App Sc, FSHP, FISAC; Michael Heung, MD, MS.

Altered kidney function:

CrCl ≥10 mL/minute: No dosage adjustment necessary (Ref).

CrCl <10 mL/minute: No dosage adjustment likely to be necessary (has not been studied); use with caution (Ref).

Hemodialysis, intermittent (thrice weekly): Unlikely to be dialyzed (highly protein bound): No dosage adjustment likely to be necessary (has not been studied); use with caution (Ref).

Peritoneal dialysis: Unlikely to be dialyzed (highly protein bound): No dosage adjustment likely to be necessary (has not been studied); use with caution (Ref).

Dosing: Hepatic Impairment: Adult

Mild-to-moderate impairment: No dosage adjustment is necessary.

Severe impairment: There are no dosage adjustments provided in the manufacturer’s labeling (has not been studied).

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

(For additional information see "Tamsulosin: Pediatric drug information")

Primary bladder neck dysfunction

Primary bladder neck dysfunction: Limited data available: Children ≥3 years and Adolescents: Oral: Initial dose: 0.2 mg once daily; increase by 0.2 mg increments based on response (symptoms and urodynamic studies) and tolerability. Mean effective dose: 0.4 mg daily; maximum reported daily dose: 0.8 mg/day. Dosing based on 2 trials evaluating treatment with alpha blockers, including over 50 pediatric patients who received tamsulosin. Treatment resulted in improved urine flow rates and decreased post-void residual urine volume; values returned to pretreatment levels when therapy was discontinued. Tamsulosin was well tolerated with no major adverse effects, and benefits continued for at least 3 years (Ref).

Ureteral calculi expulsion

Ureteral calculi expulsion: Limited data available; optimal dose not established:

Children 2 to 4 years: Oral: 0.4 mg once daily; a lower dose of 0.2 mg has also been reported; however, this dosage form may not be available in some countries including the United States and Canada (Ref).

Children >4 years and Adolescents: Oral: 0.4 mg once daily (Ref).

Dosing based on limited prospective and retrospective trials and 2 meta-analyses that evaluated the efficacy of alpha-adrenergic blockers for facilitation of spontaneous stone passage in pediatric patients with distal urolithiasis (stones were generally ≤12 mm); compared with placebo, tamsulosin was associated with greater expulsion rate and decreased expulsion time (Ref).

Dosing: Kidney Impairment: Pediatric

There are no pediatric-specific recommendations. Based on experience in adult patients with CrCl ≥10 mL/minute, data suggest no adjustment needed; for more severe renal impairment, use has not been studied.

Dosing: Hepatic Impairment: Pediatric

There are no pediatric-specific recommendations. Based on experience in adult patients with mild to moderate hepatic impairment, data suggest no adjustment needed; for more severe hepatic impairment, use has not been studied.

Adverse Reactions (Significant): Considerations
Floppy iris syndrome

Intraoperative floppy iris syndrome has been reported in patients with current or prior use of alpha-1 blockers, particularly tamsulosin, undergoing cataract or glaucoma surgery (Ref).

Mechanism: Not completely established; may be related to a combination of the pharmacologic action (ie, inhibition of the iris dilator smooth muscle contraction) and long-term smooth muscle atrophy from accumulation in iris pigment epithelial cells (Ref).

Onset: Varied; may occur with current (within a few weeks of initiation) or prior use (years following discontinuation) (Ref). A minimum 3-month duration of alpha-1 blocker use has been proposed as a risk for IFIS (Ref).

Risk factors:

• Individual alpha-1 blocker (risk highest with tamsulosin) (Ref)

• Hypertension (Ref)

• Male sex (Ref)

• Older age (Ref)

• Decreased pre-operative dilated pupil diameter (Ref)

Orthostatic hypotension

Tamsulosin is associated with orthostatic hypotension, which can manifest as dizziness and vertigo.

Mechanism: Dose-related; related to the pharmacologic action (ie, inhibition of vascular smooth muscle contraction and vasodilation) (Ref).

Onset: Rapid; “first dose” orthostatic hypotension may occur 4 to 8 hours after dose.

Risk factors:

• Individual alpha-1 blocker (risk lowest with tamsulosin) (Ref)

• First dose or redose after dose interruption (Ref)

• Rapid increase in dose

• Concurrent medications that cause orthostatic hypotension (eg, antihypertensives, nitrates, PDE-5 inhibitors) (Ref)

• Alcohol use (Ref)

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

>10%:

Cardiovascular: Orthostatic hypotension (by orthostatic testing: first dose: 6% to 7%, chronic use: 16% to 19%; symptomatic: <1%) (table 1)

Tamsulosin: Adverse Reaction: Orthostatic hypotension

Drug (Tamsulosin)

Placebo

Dose

Number of Patients (Tamsulosin)

Number of Patients (Placebo)

Comments

19%

11%

0.8 mg

491

493

Studies 1 & 2

16%

11%

0.4 mg

502

493

Studies 1 & 2

7%

3%

0.4 mg

498

253

Study 1: 4 hours after first dose

6%

4%

0.4 mg

498

250

Study 1: 8 hours after first dose

0.4%

0%

0.8 mg

492

493

Symptomatic; Studies 1 & 2

0.2%

0%

0.4 mg

502

493

Symptomatic; Studies 1 & 2

Genitourinary: Ejaculation failure (8% to 18%)

Infection: Infection (9% to 11%)

Nervous system: Dizziness (15% to 17%) (table 2), headache (19% to 21%)

Tamsulosin: Adverse Reaction: Dizziness

Drug (Tamsulosin)

Placebo

Dose

Number of Patients (Tamsulosin)

Number of Patients (Placebo)

17%

10%

0.8 mg

492

493

15%

10%

0.4 mg

502

493

Respiratory: Rhinitis (13% to 18%)

1% to 10%:

Endocrine & metabolic: Decreased libido (2%)

Gastrointestinal: Diarrhea (6%), nausea (4%)

Nervous system: Asthenia (8% to 9%), drowsiness (3% to 4%), insomnia (1% to 2%), vertigo (1%) (table 3)

Tamsulosin: Adverse Reaction: Vertigo

Drug (Tamsulosin)

Placebo

Dose

Number of Patients (Tamsulosin)

Number of Patients (Placebo)

1%

0.6%

0.8 mg

492

493

0.6%

0.6%

0.4 mg

502

493

Neuromuscular & skeletal: Back pain (7% to 8%)

Ophthalmic: Blurred vision (≤2%)

Respiratory: Increased cough (3% to 5%), pharyngitis (6%), sinusitis (4%)

Postmarketing:

Cardiovascular: Atrial fibrillation, tachycardia

Dermatologic: Contact dermatitis (Lijnen 2003), erythema multiforme (Hu 2019), exfoliative dermatitis, fixed drug eruption (Montazer 2020), skin photosensitivity (Tan 2018), Stevens-Johnson syndrome

Gastrointestinal: Constipation, vomiting, xerostomia

Genitourinary: Priapism (Marconi 2019)

Hypersensitivity: Angioedema

Ophthalmic: Choroidal detachment (Kerimoglu 2010), intraoperative floppy iris syndrome (in patients undergoing cataract or glaucoma surgery) (Keklikci 2009)

Respiratory: Dyspnea, epistaxis

Contraindications

Hypersensitivity (eg, angioedema, rash, urticaria, pruritus, respiratory symptoms) to tamsulosin or any component of the formulation

Canadian labeling: Additional contraindications (not in US labeling): Concomitant use with strong CYP3A4 inhibitors (including ketoconazole)

Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Warnings/Precautions

Concerns related to adverse effects:

• Angina: Discontinue if symptoms of angina occur or worsen.

• Sulfonamide allergy: Rarely, patients with a sulfa allergy have also developed an allergic reaction to tamsulosin; avoid use when previous reaction has been severe or life-threatening.

Disease-related concerns:

• Heart failure: In a scientific statement from the American Heart Association, tamsulosin has been determined to be an agent that may exacerbate underlying myocardial dysfunction (magnitude: moderate) (AHA [Page 2016]).

Special populations:

• Patients undergoing cataract surgery: Intraoperative floppy iris syndrome has been observed in patients undergoing cataract surgery who were on or were previously treated with alpha-1 blockers; there appears to be no benefit in discontinuing alpha-blocker therapy prior to surgery. May require modifications to surgical technique; instruct patients to inform ophthalmologist of current or previous alpha-1 blocker use when considering eye surgery.

Warnings: Additional Pediatric Considerations

Tamsulosin has been well tolerated in pediatric patients during trials when used for management of nephrolithiasis and primary bladder neck dysfunction (Donohoe 2005; Mokhless 2012; Tasian 2014; Van Batavia 2010). Studies using tamsulosin for the management of elevated detrusor leak point pressure in pediatric patients (ages 2 to 16 years) with a known neurological disorder (eg, spina bifida) failed to show efficacy.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Capsule, Oral, as hydrochloride:

Flomax: 0.4 mg [contains fd&c blue #2 (indigotine,indigo carmine)]

Generic: 0.4 mg

Generic Equivalent Available: US

Yes

Pricing: US

Capsules (Flomax Oral)

0.4 mg (per each): $11.67

Capsules (Tamsulosin HCl Oral)

0.4 mg (per each): $0.53 - $4.22

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Capsule Extended Release 24 Hour, Oral:

Generic: 0.4 mg

Tablet Extended Release 24 Hour, Oral:

Flomax CR: 0.4 mg

Generic: 0.4 mg

Administration: Adult

Oral: Administer capsules ~30 minutes after the same mealtime each day. Per the manufacturer’s labeling, capsules should be swallowed whole; do not crush, chew, or open. In pediatric trials, capsules were opened and the contents mixed with food (eg, yogurt or pudding) or juice (Ref); however, if administered via this method, do not crush, chew, or dissolve the granules as this may lead to rapid release and increased risk of adverse effects (manufacturer data on file). Administration via nasogastric, gastric, jejunostomy, or other feeding tubes has not been adequately evaluated, and based on limited reports, the granules may adhere to the tube with resultant blockage (manufacturer data on file). The controlled-release tablet [Canadian product] should be administered at the same time each day with or without food, and should be swallowed whole.

Administration: Pediatric

Oral: Per the manufacturer, capsules should be swallowed whole; do not crush, chew, or open. In pediatric trials, capsules were opened and the contents mixed with food (eg, yogurt, pudding), water, or juice (Ref); however, if administered via this method, do not crush, chew, or dissolve the granules as this may lead to rapid release and increased risk of adverse effects (manufacturer data on file). Administration via nasogastric, gastric, jejunostomy, or other feeding tubes has not been adequately evaluated, and based on limited reports, the granules may adhere to the tube with resultant blockage (manufacturer data on file).

Use: Labeled Indications

Benign prostatic hyperplasia: Treatment of signs and symptoms of benign prostatic hyperplasia (BPH)

Limitations of use: Not indicated for the treatment of hypertension.

Use: Off-Label: Adult

Chronic prostatitis/chronic pelvic pain syndrome in males; Lower urinary tract symptoms in males; Ureteral stone(s), expulsion; Ureteral stent-related urinary symptoms, treatment

Medication Safety Issues
Sound-alike/look-alike issues:

Flomax may be confused with Flonase, Flovent, Foltx, Fosamax

Tamsulosin may be confused with tacrolimus, tamoxifen, terazosin

International issues:

Flomax [US, Canada, and multiple international markets] may be confused with Flomox brand name for cefcapene [Japan]; Volmax brand name for salbutamol [multiple international markets]

Flomax: Brand name for tamsulosin [US, Canada, and multiple international markets], but also the brand name for morniflumate [Italy]

Metabolism/Transport Effects

Substrate of CYP2D6 (major), CYP3A4 (major); Note: Assignment of Major/Minor substrate status based on clinically relevant drug interaction potential

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.

Ajmaline: May increase the serum concentration of CYP2D6 Substrates (High risk with Inhibitors). Risk C: Monitor therapy

Alpha-/Beta-Agonists: Alpha1-Blockers may diminish the vasoconstricting effect of Alpha-/Beta-Agonists. Similarly, Alpha-/Beta-Agonists may antagonize Alpha1-Blocker vasodilation. Risk C: Monitor therapy

Alpha1-Agonists: Alpha1-Blockers may diminish the vasoconstricting effect of Alpha1-Agonists. Similarly, Alpha1-Agonists may antagonize Alpha1-Blocker vasodilation. Risk C: Monitor therapy

Alpha1-Blockers: May enhance the antihypertensive effect of other Alpha1-Blockers. Risk X: Avoid combination

Amifostine: Blood Pressure Lowering Agents may enhance the hypotensive effect of Amifostine. Management: When used at chemotherapy doses, hold blood pressure lowering medications for 24 hours before amifostine administration. If blood pressure lowering therapy cannot be held, do not administer amifostine. Use caution with radiotherapy doses of amifostine. Risk D: Consider therapy modification

Amisulpride (Oral): May enhance the hypotensive effect of Hypotension-Associated Agents. Risk C: Monitor therapy

Antipsychotic Agents (Second Generation [Atypical]): Blood Pressure Lowering Agents may enhance the hypotensive effect of Antipsychotic Agents (Second Generation [Atypical]). Risk C: Monitor therapy

Arginine: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Risk C: Monitor therapy

Artemether and Lumefantrine: May increase the serum concentration of CYP2D6 Substrates (High risk with Inhibitors). Risk C: Monitor therapy

Barbiturates: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Risk C: Monitor therapy

Benperidol: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Risk C: Monitor therapy

Blood Pressure Lowering Agents: May enhance the hypotensive effect of Hypotension-Associated Agents. Risk C: Monitor therapy

Brimonidine (Topical): May enhance the hypotensive effect of Blood Pressure Lowering Agents. Risk C: Monitor therapy

Bromperidol: May diminish the hypotensive effect of Blood Pressure Lowering Agents. Blood Pressure Lowering Agents may enhance the hypotensive effect of Bromperidol. Risk X: Avoid combination

Cimetidine: May increase the serum concentration of Tamsulosin. Risk C: Monitor therapy

Clofazimine: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Risk C: Monitor therapy

CYP2D6 Inhibitors (Moderate): May increase the serum concentration of Tamsulosin. Risk C: Monitor therapy

CYP2D6 Inhibitors (Strong): May increase the serum concentration of Tamsulosin. Risk C: Monitor therapy

CYP3A4 Inhibitors (Moderate): May increase the serum concentration of Tamsulosin. Risk C: Monitor therapy

CYP3A4 Inhibitors (Strong): May increase the serum concentration of Tamsulosin. Risk X: Avoid combination

Dapoxetine: May enhance the orthostatic hypotensive effect of Alpha1-Blockers. Risk C: Monitor therapy

Diazoxide: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Risk C: Monitor therapy

DULoxetine: Blood Pressure Lowering Agents may enhance the hypotensive effect of DULoxetine. Risk C: Monitor therapy

Fexinidazole: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Risk X: Avoid combination

Fusidic Acid (Systemic): May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Risk X: Avoid combination

Herbal Products with Blood Pressure Lowering Effects: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Risk C: Monitor therapy

Hypotension-Associated Agents: Blood Pressure Lowering Agents may enhance the hypotensive effect of Hypotension-Associated Agents. Risk C: Monitor therapy

Levodopa-Foslevodopa: Blood Pressure Lowering Agents may enhance the hypotensive effect of Levodopa-Foslevodopa. Risk C: Monitor therapy

Lormetazepam: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Risk C: Monitor therapy

Molsidomine: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Risk C: Monitor therapy

Nicorandil: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Risk C: Monitor therapy

Nitroprusside: Blood Pressure Lowering Agents may enhance the hypotensive effect of Nitroprusside. Risk C: Monitor therapy

Obinutuzumab: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Management: Consider temporarily withholding blood pressure lowering medications beginning 12 hours prior to obinutuzumab infusion and continuing until 1 hour after the end of the infusion. Risk D: Consider therapy modification

Peginterferon Alfa-2b: May decrease the serum concentration of CYP2D6 Substrates (High risk with Inhibitors). Peginterferon Alfa-2b may increase the serum concentration of CYP2D6 Substrates (High risk with Inhibitors). Risk C: Monitor therapy

Pentoxifylline: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Risk C: Monitor therapy

Pholcodine: Blood Pressure Lowering Agents may enhance the hypotensive effect of Pholcodine. Risk C: Monitor therapy

Phosphodiesterase 5 Inhibitors: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Risk C: Monitor therapy

Phosphodiesterase 5 Inhibitors: Alpha1-Blockers (Uroselective) may enhance the hypotensive effect of Phosphodiesterase 5 Inhibitors. Risk C: Monitor therapy

Prostacyclin Analogues: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Risk C: Monitor therapy

Quinagolide: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Risk C: Monitor therapy

Rilmenidine: Alpha1-Blockers may enhance the hypotensive effect of Rilmenidine. Risk C: Monitor therapy

Food Interactions

Capsules: Fasting increases bioavailability by 30% and peak concentration 40% to 70%. Management: Administer 30 minutes after the same meal each day. Note: The controlled-release tablet formulation [Canadian product] is not affected by food and can be taken with or without food at the same time each day.

Reproductive Considerations

Ejaculation failure, ejaculation disorder, retrograde ejaculation, and decreased ejaculation has been associated with use of tamsulosin.

Pregnancy Considerations

Information related to the use of tamsulosin for ureteral calculi expulsion in pregnancy is limited (Bailey 2016; Theriault 2020). Other treatments such as stents or ureteroscopy, are currently recommended if stone removal is needed (AUA/ES [Assimos 2016]; EAU [Türk 2019]; Lloyd 2016).

Breastfeeding Considerations

It is not known if tamsulosin is present in breast milk.

Monitoring Parameters

International Prostate Symptom Score (baseline and 4 to 12 weeks after treatment initiation); urinalysis (baseline); BP; prostate cancer screening prior to initiation and then as directed; mental alertness; objective and subjective signs of relief of benign prostatic hyperplasia and lower urinary tract symptoms (AUA [Lerner 2021]; manufacturer’s labeling).

Mechanism of Action

Tamsulosin is an antagonist of alpha1A-adrenoreceptors in the prostate. Smooth muscle tone in the prostate is mediated by alpha1A-adrenoreceptors; blocking them leads to relaxation of smooth muscle in the bladder neck and prostate causing an improvement of urine flow and decreased symptoms of BPH. Approximately 75% of the alpha1-receptors in the prostate are of the alpha1A subtype.

Pharmacokinetics (Adult Data Unless Noted)

Note: Pharmacokinetics in pediatric patients (ages 2 to 16 years) were found to be similar to adult values (Tsuda 2010).

Absorption: >90%

Distribution: Vd: 16 L

Protein binding: 94% to 99%, primarily to alpha-1 acid glycoprotein (AAG)

Metabolism: Hepatic (extensive) via CYP3A4 and 2D6; metabolites undergo extensive conjugation to glucuronide or sulfate

Bioavailability: Fasting: 30% increase

Steady-state: By the fifth day of once-daily dosing

Half-life elimination: Healthy volunteers: 9 to 13 hours; Target population: 14 to 15 hours

Time to peak: Fasting: 4 to 5 hours; With food: 6 to 7 hours

Excretion: Urine (76%, <10% as unchanged drug); feces (21%)

Pharmacokinetics: Additional Considerations (Adult Data Unless Noted)

Older adult: AUC is 40% higher in subjects 55 to 75 years of age compared with subjects 20 to 32 years of age.

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Gamcet | Od tam | Omnic | Omnic ocas | Prosta Tab | Prostulosin | Tamictor | Tamsumac | Urimax;
  • (AR) Argentina: Aclosan | Biprokam | Controlpros | Denverprost | Diufortan | Espontal | Flocprox | Lostam | Omnic | Prostoklar | Reduprost | Secotex | Sulos | Tamsulosina Richet | Tamsulosina teva | Tamsuna | Tansiloprost | Tarusol | Toloxane | Travelgum | Uralos | Uriflux | Urocetina | Uroprost Q;
  • (AT) Austria: Aglandin | Alna | Omix | Tamsulosin +Pharma | Tamsulosin 1a pharma | Tamsulosin actavis | Tamsulosin Easypharm | Tamsulosin genericon | Tamsulosin Hexal | Tamsulosin Interpharm | Tamsulosin krka | Tamsulosin ratiopharm | Tamsulosin sandoz | Tamsulosin stada | Tamsulosin-Arcana | Tamsunova;
  • (AU) Australia: Apo tamsulosin sr | Flomax | Flomaxtra | Flosix | Tamsulosin sandoz;
  • (BD) Bangladesh: Eziflo | Ezipas | Flonor | Hi flow | Maxrin | Mictrol | Prostacin | Prostanil | Sasolin | Tamcontin | Tamfast | Tamlosin | Tamsin | Tamsol | Tamsule | Uricare | Urinom | Urocap | Uroflo | Urolosin | Uromax | Uropass | Urotam;
  • (BE) Belgium: Omic | Tamsulos Aes | Tamsulosine Docpharma | Tamsulosine eg | Tamsulosine hcl krka | Tamsulosine Merck | Tamsulosine Ratiopharm | Tamsulosine sandoz | Tamsulosine Teva;
  • (BG) Bulgaria: Fokusin | Fokusin sr | Omnic | Omnic tocas | Tamaliz | Tamsol | Tamsucon | Tamsudil | Tanyz | Urimax;
  • (BR) Brazil: Cloridrato de tansulosina | Contiflo | Omnic | Omnic ocas | Rettan | Secotex | Secotex Adv | Stub | Tamsulon | Tansudart | Tasulil | Usoleg;
  • (CH) Switzerland: Omix | Pradif | Tamsulosin | Tamsulosin actavis | Tamsulosin axapharm | Tamsulosin Helvepharm | Tamsulosin Mepha | Tamsulosin mylan | Tamsulosin retard zentiva | Tamsulosin sandoz | Tamsulosin sandoz eco | Tamsulosin Spirig | Tamsulosin spirig hc | Tamsulosin Streuli | Tamsulosin T | Tamsulosin t helvepharm | Tamsulosin t mepha | Tamsulosin t spirig hc | Tamsulosin teva | Tamsunax;
  • (CL) Chile: Eupen | Gotely | Nefex | Omnic | Prostall | Secotex | Secotex ocas | Singotex | Sulix | Tamsol | Tamsulosina | Vi Uril;
  • (CN) China: Bi tan | Harnal | Ji da ben te | Ji suo | Qi suo;
  • (CO) Colombia: Demulin er | Od tam | Omnic | Omnic ocas | Proslosin | Secotex | Secotex ocas | Sulosin | Tamsecox | Tamsulon | Tamsulosin | Tamsulosina | Tamsulosina clorhidrato | Tamsulosina sandoz | Tamsumax | Valudar;
  • (CZ) Czech Republic: Apo Tamis | Fokusin | Lannatam | Omnic | Omnic tocas | Taflosin | Tamipro | Tamsulonorm | Tamsulosin +Pharma | Tamsulosin aurovitas | Tamsulosin hcl Sandoz | Tamsulosin hcl teva | Tamurox | Tanyz eras;
  • (DE) Germany: Alna | Alna Ocas | Omnic | Omsula | Prostacure | Prostadil | Prostalitan | Tadin | Tamsu astellas | Tamsu-Q | Tamsublock | Tamsulo-Isis | Tamsulosin 1a pharma | Tamsulosin AbZ | Tamsulosin AL | Tamsulosin aristo | Tamsulosin Aurobindo | Tamsulosin basics | Tamsulosin basics sun | Tamsulosin beta | Tamsulosin Biomo | Tamsulosin CT | Tamsulosin Hexal | Tamsulosin ratiopharm | Tamsulosin sandoz | Tamsulosin stada | Tamsulosin Winthrop | Tamsulosin zentiva | Tamsulosinhydrochlorid actavis | Tamsulosinhydrochlorid Awd | Tamsulosinhydrochlorid Heumann | Tamsumedin | Tamsunar;
  • (DK) Denmark: Cepalux | Masulin | Omnistad | Tamsin;
  • (DO) Dominican Republic: Espontal | Fulmen | Gaflox | Normacid | Prosina | Prostamida | Prostoklar | Protober | Secotex | Secotex ocas | Soluprost | Tamsul | Tamsulon | Tamsulosina | Tamsulosina ethical | Tamsulosina hcl | Taven | Urisan | Veltam;
  • (EC) Ecuador: Amsulona | Contiflo | Eupen | Hiprostam | Lostam | Oxialprost | Prostall | Prostoklar | Secotex | Tamsina | Tamsulon | Tamsulosina | Tamsulosina nifa;
  • (EE) Estonia: Flosin | Fokusin | Omnic | Omnic tocas | Omsal | Tamsulosin auxilia | Tamsulosin lannacher | Tamsulosin sandoz | Tamsulosin stada | Tanyz | Tanyz eras | Urostad;
  • (EG) Egypt: Block alpha | Cure pro | Curepro xr | Firamazin | Kemprost | Kemprost sr | Losiprost | Normirama | Omnic | Tamic | Tamsul | Tamsulin | Tamsulosin | Tamsunorm;
  • (ES) Spain: Inreq | Omnic ocas | Sebrane | Sebrane neo | Tamsulosina almus | Tamsulosina Alter | Tamsulosina Apotex | Tamsulosina Aurobindo | Tamsulosina Cinfa | Tamsulosina combix | Tamsulosina Cuve | Tamsulosina Davur | Tamsulosina Inibsa | Tamsulosina Kern Pharma | Tamsulosina krka | Tamsulosina Mabo | Tamsulosina Mylan Pharmaceuticals | Tamsulosina Normon | Tamsulosina Pensa | Tamsulosina Pharmagenus | Tamsulosina Qualigen | Tamsulosina Ratiopharm | Tamsulosina sandoz | Tamsulosina Stada | Tamsulosina Tarbis | Tamsulosina Tecnigen | Tamsulosina teva | Tamsulosina vir | Tamsulosina Winthrop | Tamsulosina zentiva | Urolosin | Urolosin ocas | Zuantrip;
  • (ET) Ethiopia: Od tam;
  • (FI) Finland: Expros | Omnic | Omnic ocas | Promictan | Tamictor | Tamsact | Tamsu-Anlini | Tamsucinfa | Tamsufarm | Tamsugaran | Tamsulosiinihydrokloridi arrow | Tamsulosiinihydrokloridi Krka | Tamsulosiinihydrokloridi Orion | Tamsulosiinihydrokloridi Sandoz | Tamsumin | Tamsupli;
  • (FR) France: Josir | Mecir | Omexel | Omix | Tamsulosine | Tamsulosine actavis | Tamsulosine Almus | Tamsulosine Arrow | Tamsulosine Biogaran | Tamsulosine eg | Tamsulosine evolugen | Tamsulosine isomed | Tamsulosine krka LP | Tamsulosine Mylan | Tamsulosine ranbaxy | Tamsulosine sandoz | Tamsulosine Teva | Tamsulosine Winthrop | Tamsulosine zentiva | Tamsulosine zydus france;
  • (GB) United Kingdom: Alphacard | Contiflo | Diffundox | Faramsil | Flectone | Flomax | Flomax Relief | Flomax relief mr | Flomaxtra xl | Galebon | Losinate | Losinate mr | Omsula | Pamsvax | Pamsvax Almus | Petyme | Pinexel | Prosurin | Stronazon | Tabphyn MR | Tamfrex xl | Tamsaprost | Tamsulosin | Tamsulosin Almus | Tamsumac | Tamurex;
  • (GR) Greece: Novelio | Omnic | Pradif | Prosolvin | Ranomax | Sintamel | Tamsol | Tamsolet | Tamsulijn | Tamsulosin/ariti | Tamsulosin/Generics | Tamsulosin/mylan | Zidrolin;
  • (HK) Hong Kong: Apo tamsulosin | Harnal | Harnal ocas | Maxrin | Tamsulosin;
  • (HR) Croatia: Bazetham | Flosin | Modiar | Omnic | Omnic ocas | Tamaliz | Tamosin | Tamsich | Tamsu | Tamsulozin PharmaS | Tanyz | Tanyz eras | Urimax;
  • (HU) Hungary: Flosin | Omipro | Omnic | Omnic tocas | Prosolin | Provosal | Tamsulonorm | Tamsulosin | Tamsulosin Pharmacenter | Tanyz eras | Totalprost | Uro tam;
  • (ID) Indonesia: Harnal | Tamsulosin;
  • (IE) Ireland: Kirnom XL | Omnexel | Omnic | Omsil | Prolosin | Tamnexyl | Tamnic | Tamsu | Tamsulosin | Tamzeltos | Tanyz;
  • (IL) Israel: Omnic | Promnix | Tamsulin;
  • (IN) India: Aivo | Alfatam | Bezip | Consistam | Contiflo | Dynapres | Flokind | Flomax | Fulflow | Geritam | Jyotam | Protam | Reflow | Tamby | Tamcuf | Tamdosin | Tamflo | Tamgress | Tamlocept | Tamlosig | Tampres | Tamsin | Tamstream | Tamsufine | Tamsuhenz | Tamsukem | Tamsulin | Tasulin | Temsujohn | Urigrip | Urimax | Urinat | Urinice | Uripro | Urisurge | Uritin | Uronex | Veltam;
  • (IT) Italy: Antunes | Botam | Lura | Omnic | Pradif | Tamsulosina | Tamsulosina Acv | Tamsulosina almus | Tamsulosina arrow | Tamsulosina Aurobindo | Tamsulosina Fg | Tamsulosina fidia | Tamsulosina krka | Tamsulosina sandoz | Uromen;
  • (JO) Jordan: Eziflo | Omnic | Omnic ocas | Prostanic | Tamsin | Uriflo;
  • (JP) Japan: Halonerol | Halthrow | Haranasin | Harleave | Harnal | Harnnat | Hartam | Palnac | Restream | Tamslon | Tamsulosin HCL | Tamsulosin Hcl Kowa | Tamsulosin Hcl Ohara | Tamsulosin Hcl Taisho | Tamsulosin Hcl Takata | Urosulol;
  • (KE) Kenya: Contiflo od | Eziflo | Flomax | Flosure | Maxflow | Plastum | Prostaflo od | Tamcontin | Tamsolin | Tamsumac | Tamzed | Weltam xl;
  • (KR) Korea, Republic of: Arlunal sr | Bearosin | Bearosin sr | Binex tamsrosin hcl | Binex tamsrosin hcl er | Boryung tamsulosin hcl | Boryung tamsulosin hcl sr | C trocin sr | Citrosin sr | Dongkwang tamsulosin sr | Dongsung tamsulosin | Genilosin | Habi sr | Hanall tamsulosin | Hanmi tams | Harlosin D | Harlosin sr | Harnal | Harnal d | Haru d sr | Harucare | Harucin sr | Harucure | Harucure sr | Harulon sr | Harutam | Harutam sr | Hyundai tamsulosin hcl | Inist tamsulosin | Inist tamsulosin sr | K tams sr | Lutsnal | Neolosin | Neorocin | Neorosin | Pharma tamsulosin | Pratam sr | Qminal | Qminal sr | Samsung tamsulosin sr | Scarocin | Silontam sr | Siwonal | Siwonal sr | Sulosin | Sulosin D | Tamilosin SR | Taminal | Tamlos | Tamlosin | Tamlosin sr | Tamlostar | Tamlostar sr | Tamlusin | Tamlusin d sr | Tamlusindi sr | Tampasin sr | Tampilon | Tams | Tamscare | Tamsdol | Tamsen | Tamsen sr | Tamsil sr | Tamsilo SR | Tamsin | Tamsin sr | Tamslen sr | Tamslo | Tamslon sr | Tamslusin | Tamsmin | Tamsnal | Tamsnal sr | Tamsol | Tamsol sr | Tamsonal | Tamsosin | Tamsosin sr | Tamspeed | Tamspin | Tamspla | Tamspon | Tamspro sr | Tamsro | Tamsrosin hcl | Tamsta | Tamstar SR | Tamsthroa | Tamstro | Tamstro SR | Tamsudol SR | Tamsul m | Tamsul m sr | Tamsul sr | Tamsulo | Tamsulogen sr | Tamsuloisin | Tamsulol er | Tamsulon | Tamsulonal sr | Tamsulosin | Tamsulosin sr | Tamsunal | Tamsuro sr | Tamsuron | Tamsurosin sr | Tamswel | Tamszin sr | Tamulon | Tamulosin | Tamunal | Tarosin sr | Tarunal | Time s | Timeal | Tipilosin | Unilosin | Urinstar sr | Uronal | Uropa sr | Urotams sr | Utanal | Utanal sr;
  • (KW) Kuwait: Eziflo | Omnic | Prosta Tab PR | Tamsulin;
  • (LB) Lebanon: Apo tamsulosin | Omnic | Pinexel pr | Prostafine | Talusin | Tamsulin;
  • (LT) Lithuania: Flosin | Fokusin | Omnic | Omsal | Ranomax | Tamsulosin lannacher | Tamsulosin stada | Tanyz eras | Urostad;
  • (LU) Luxembourg: Doctamsulosine | Omic | Ranomax | Tamsulosin Hexal | Tamsulosin ratiopharm | Tamsulosine eg | Tamsulosine hydrochloride yamanouchi pharma;
  • (LV) Latvia: Omnic | Omsal | Ranomax | Tamipro | Tamosin | Tamsulosin | Tamsulosin norameda | Tamsulosin stada | Tanyz eras | Urostad;
  • (MA) Morocco: Contiflo | Tamsulosine win | Umax;
  • (MX) Mexico: Alfatam | Alphalock | Amzuvag | Asoflon | Delitam | Dronelyn tec | Fedpros | Flucisten | Grandlord | Hipebe | Jumslim | Kresulix | Nondecel | Ormusul | Perplax | Prerikusine | Secadryckel | Secotex | Secotex ocas | Sedoty | Suprosina | Tamablan | Tamablan pf | Tamsulosina | Tatsocap | Texulon | Uprosol | Weltam | Zulotam;
  • (MY) Malaysia: Harnal | Tamsin forte;
  • (NG) Nigeria: Contiflo od | Flowel | Glomaxtra xl | Hansulosin | Lifeback tamsulosin | Norlosin xl | Tamsulosin | Tamsumac;
  • (NL) Netherlands: Mapelor ocas | Omnic | Tamsulosin | Tamsulosine genthon | Tamsulosine HCl A | Tamsulosine Hcl Actavis | Tamsulosine HCl Aurobindo | Tamsulosine Hcl CF | Tamsulosine hcl merck | Tamsulosine HCl Mylan | Tamsulosine hcl ratiopharm | Tamsulosine hcl retard teva | Tamsulosine hcl sandoz | Tamsulosine hcl sun | Tamsulosine hydrochloride Genthon | Tamsulosine Mylan | Tamsulosine sandoz | Tamsulosinehydrochloride PCH;
  • (NO) Norway: Cepalux | Miktosan | Omnic | Tamsulosin | Tamsulosin arrow | Tamsulosin Hexal | Tamsulosin mylan | Tamsulosin ratiopharm | Tamsulosin teva;
  • (NZ) New Zealand: Flomax | Tamsulosin Rex;
  • (PE) Peru: Adeprost | Aliner s | Amsulona | Ditamsuloss | Ecksulona | Glancin | Maxflo | Omnic | Oriflow | Prostadel | Secotex | Secotex ocas | Tamsul | Tamsulip | Tamsulofar | Tamsulon | Tamsulosina | Tamsulosina clorhidrato | Tamta | Uriglob | Veltam;
  • (PH) Philippines: Alfatam | Amso | Harnal | Pimax | Prostalife | Prostazin | Prozelax | Proztab ER | Sulopros | Sultam | Tamsia | Tamsilon | Tamsolin | Tamsul | Tamsulon xl | Tamsulosin | Tamsumax | Tamzor | Tamzu | Urilax | Urimax | Uritam | Urolosin | Urotosin;
  • (PK) Pakistan: Alfamax | Alfatam | Alfawrd sr | Colspa | Contiflo | Dribble sr | Ezurin | Flomex | Flonorm | Flosure | Flowmax | Flowset sr | Lamt | M sol | Maxflow | Maxron | Maxsure | Maylan | Medsolin | Proset | Prostam | Prostop | Prostreat | Saiflow | Solosin sr | Sulo | T sin | Talosin | Talsin | Tamcap | Tamcin | Tamiso mr | Tamlin mr | Tamline | Tampro | Tams g | Tamsar | Tamsol | Tamsolin | Tamsugene sr | Tamsulis | Tamsuna | Tasipan | Tasoline | Tasudil | Telosin | Temgal | Teslosin sr | Timsol | Tosson | Tulosin mr | Uratim | Uricare | Uriflow | Urimax | Uripro | Uritreat | Urivent | Urosul;
  • (PL) Poland: Adatam | Adatam XR | Apo Tamis | Bazetham | Fokusin | Omnic | Omsal | Prostamnic | Proximic | Ranlosin | Symlosin | Tamiron | Tamispras | Tamoptim | Tamsiger | Tamsudil | Tamsugen | Tamsulek | Tamsulosin Genoptim | Tamsunorm | Tanyz eras | Uprox | Uprox xr | Urostad;
  • (PR) Puerto Rico: Flomax | Tamsulosin | Tamsulosin HCL | Tamsulosin hydrchloride;
  • (PT) Portugal: Magrir | Omnic | Pradif | Sebrane xr | Tansulosina | Tansulosina Aurobindo | Tansulosina germed | Tansulosina Krka | Tansulosina Labesfal | Tansulosina Sandoz | Tansulosina Zentiva;
  • (PY) Paraguay: Androsist | Eupen | Ferona | Lostam | Nasul | Prostar | Secotex ocas | Tamsucar | Tamsulon | Tamsulosina celsius | Tamsulosina hcl | Tamsulosina imedic | Tamsulosina lp prosalud | Tamsulosina sandoz | Tamsulosina savant pharm | Torpas | Urotic;
  • (QA) Qatar: Contiflo OD | EZIFLO-UPM | Flomax | Gamcet | Omnic Ocas | Prosta-Tab PR | Tamsolin;
  • (RO) Romania: Contiflo mr | Fokusin | Omnic tocas | Seldono | Tamsol | Tanyz;
  • (RU) Russian Federation: Fokusin | Glancin | Glansin | Hyperprost | Mictosin | Omnic | Omnic ocas | Omsulosin | Proflosin | Revokarin | Sonizin | Tamsulon | Tamsulon fs | Tamsulosin | Tamsulosin bacter | Tamsulosin binergia | Tamsulosin canon | Tamsulosin obl | Tamsulosin roslex | Tamsulosin teva | Tamzelin | Tanyz eras | Tanyz K | Tulosin;
  • (SA) Saudi Arabia: Cigapro | Gamcet | Harnal | Omnic;
  • (SE) Sweden: Tamicten;
  • (SG) Singapore: Harnal | Harnal ocas | Tasulose;
  • (SI) Slovenia: Bazetham | Miktan | Omnic | Taflosin | Tamlos | Tamsulozin mylan | Tanyz | Tanyz eras;
  • (SK) Slovakia: Flosin | Fokusin | Geroprostan | Omipro | Omnic | Solesmin | Tamsulosin +Pharma | Tamsulosin Merck | Tamsulosin Pharmacenter | Tamsulosin teva | Tamsulozin | Tanyz | Tanyz eras | Urostad | Urotam;
  • (SY) Syrian Arab Republic: Omixase;
  • (TH) Thailand: Harnal | Uroflow;
  • (TN) Tunisia: Josir | Mecir | Omix | Omnic ocas | Prostam;
  • (TR) Turkey: Flomax | Floprost MR | Tamidra | Tocas | Uromax;
  • (TW) Taiwan: Alfatam | Elegant | Harnalidge | Harnalidge ocas | Holigin | Maxflow | Tamlosin | Tamlosin d | Tamokas | Tamso | Tamsulosin | Urnal | Zotan;
  • (UA) Ukraine: Adenorm | Alfatam | Basetam | Flosin | Fokusin | Omlos | Omnic | Omniprost | Tamsin forte | Tanyz | Urimak | Urofrin;
  • (UG) Uganda: Tamcontin;
  • (UY) Uruguay: Prostam | Prostoklar | Secoprost | Secotex | Urolosin;
  • (VE) Venezuela, Bolivarian Republic of: Sasolin mr | Secotex | Secotex ocas | Sulix | Sulixtra | Tamostin | Tamsulon | Tamsulosina | Tamsulosina clorhidrato | Tamsupros | Tamsuwell | Tansulosina;
  • (VN) Viet Nam: Floezy | Xalgetz;
  • (ZA) South Africa: Beniprosin | Flomax | Omsal | Pravlex | Prostaflo | Uromax;
  • (ZM) Zambia: Contiflo | Urimax;
  • (ZW) Zimbabwe: Contiflo od
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