Fiebig stages of early HIV infection

Fiebig stage	Cumulative duration (days)	HIV RNA	p24 antigen	Immunoassay	Western blot
1	5	+	–	–	–
2	10	+	+	–	–
3	14	+	+	+	–
4	19	+	+/–	+	Indeterminate
5	88	+	+/–	+	+ (p31 band negative)
6	Open-ended	+	+/–	+	+ (p31 band positive)

The Fiebig stages describe the emergence of virologic and immunologic markers following infection with HIV. Immunoassays and Western blot testing detect antibodies against HIV antigens.

HIV: human immunodeficiency virus.

Adapted from: Fiebig EW, Wright DJ, Rawal BD, et al. Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection. AIDS 2003; 17:1871.

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