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Minoxidil (topical): Drug information

Minoxidil (topical): Drug information
(For additional information see "Minoxidil (topical): Patient drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Gainextra Mens;
  • Hair Regrowth Treatment Men [OTC];
  • Minoxidil for Men [OTC];
  • Rogaine Mens Extra Strength [OTC];
  • Rogaine Mens [OTC];
  • Rogaine Womens [OTC]
Brand Names: Canada
  • Apo-Gain;
  • Hair Regrowth Formula;
  • Minox;
  • Rogaine
Pharmacologic Category
  • Topical Skin Product
Dosing: Adult
Alopecia

Alopecia: Topical: Note: Continuous therapy for 4 months may be necessary for hair growth.

Females:

Foam, aerosol 5%: Apply 1/2 capful once daily.

Solution 2%: Apply 1 mL twice daily.

Males:

Foam, aerosol 5%: Apply 1/2 capful twice daily.

Solution 2% or 5%: Apply 1 mL twice daily.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling

Dosing: Older Adult

Refer to adult dosing.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

Dermatologic: Local erythema (6%), pruritus (6%)

Contraindications

OTC labeling: When used for self-medication, do not use if your degree of hair loss is different than that shown on the product labeling; if you have no family history of hair loss; if your hair loss is sudden and/or patchy; if your hair loss is associated with childbirth; if you do not know the reason for your hair loss; in pediatric patients <18 years; if your scalp is red, inflamed, infected, irritated, or painful; or you use other medicines on the scalp. Do not use products on females that are labeled for use on males.

Warnings/Precautions

Concerns related to adverse effects:

• Hair color changes: Changes in hair color and/or texture may occur.

Disease-related concerns:

• Heart disease: Due to potential systemic absorption with subsequent fluid/electrolyte changes, a careful risk to benefit assessment should be performed in patients with heart disease before the use of topical minoxidil.

Dosage form specific issues:

• Flammable: Formulations are flammable; avoid fire, flame, or smoking immediately following application.

Other warnings/precautions:

• Appropriate use: For topical use only on the scalp; do not apply to other parts of the body. Avoid contact with eyes, mouth, nose, or other mucous membranes. Not intended for frontal baldness or receding hairline Continued use is necessary to increase and maintain hair regrowth.

• Self-medication (OTC use): When used for self-medication (OTC), discontinue use and contact your contact health care provider if chest pain, rapid heartbeat, faintness, or dizziness occurs; weight gain (sudden, unexplained) occurs; swelling of the hands or feet occurs; scalp irritation or redness occurs; unwanted facial hair growth occurs; if you do not see hair regrowth 4 to 6 months (product dependent).

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Foam, External:

Gainextra Mens: 5% (60 g) [contains cetyl alcohol]

Rogaine Mens: 5% (60 g) [contains cetyl alcohol]

Rogaine Mens Extra Strength: 5% (60 mL) [contains cetyl alcohol]

Rogaine Womens: 5% (60 g) [contains cetyl alcohol]

Solution, External:

Hair Regrowth Treatment Men: 5% (60 mL) [contains alcohol, usp, propylene glycol]

Minoxidil for Men: 2% (60 mL); 5% (60 mL, 120 mL)

Rogaine: 2% (60 mL) [contains alcohol, usp, propylene glycol]

Rogaine Extra Strength for Men: 5% (60 mL) [contains alcohol, usp, propylene glycol]

Generic: 2% (60 mL); 5% (60 mL)

Generic Equivalent Available: US

May be product dependent

Pricing: US

Foam (Rogaine Mens Extra Strength External)

5% (60 g): $27.37

Disclaimer: The pricing data provide a representative AWP and/or AAWP price from a single manufacturer of the brand and/or generic product, respectively. The pricing data should be used for benchmarking purposes only, and as such should not be used to set or adjudicate any prices for reimbursement or purchasing functions. Pricing data is updated monthly.

Administration: Adult

Topical: For topical administration on the scalp only; do not use on other parts of the body. Apply directly to the hair- thinning areas of scalp; massage into scalp with fingers; wash hands after application. Refer to manufacturer’s labeling for additional administration instructions.

Foam: May melt upon contact with warm fingers; rinse fingers in cold water and thoroughly dry prior to use

Use: Labeled Indications

Alopecia: Treatment of alopecia androgenetica of the scalp

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Pregnancy Considerations

Adverse events have been observed in some animal reproduction studies following oral administration.

Breastfeeding Considerations

Minoxidil is excreted in breast milk following oral administration.

Mechanism of Action

Stimulation of hair growth is secondary to vasodilation, increased cutaneous blood flow, and stimulation of resting hair follicles.

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Regaine;
  • (AT) Austria: Regaine;
  • (AU) Australia: Regaine;
  • (CL) Chile: Anagen;
  • (CO) Colombia: Edapil m | Follirest | Mino | Tylcore;
  • (DE) Germany: Regaine;
  • (DO) Dominican Republic: Edapil m;
  • (EC) Ecuador: Edapil m;
  • (EG) Egypt: Hair plus back | Regaine;
  • (FR) France: Alostil;
  • (GR) Greece: Regaine;
  • (IE) Ireland: Regaine;
  • (IN) India: Tugain;
  • (JO) Jordan: Regaine;
  • (KR) Korea, Republic of: Rogaine;
  • (KW) Kuwait: Regaine;
  • (NZ) New Zealand: Women's regaine;
  • (PE) Peru: Edapil m;
  • (PR) Puerto Rico: Women's Rogaine;
  • (QA) Qatar: Alopexy | Bald X | Hairgaine for Men | Hairgaine for Women | Hairgrow | Minoxil | Minoxil Forte | Regaine for Men Extra Strength | Regaine Regular Strength;
  • (RO) Romania: Regaine;
  • (RU) Russian Federation: Regaine;
  • (SI) Slovenia: Regaine;
  • (TR) Turkey: Androvium;
  • (TW) Taiwan: Folux Foaming | Regaine | Regaine women | Revoco hair
  1. Minoxidil Regular Strength solution [prescribing information]. San Antonio, TX: H-E-B; March 2008.
  2. Rogaine Men's Extra Strength foam (minoxidil) [prescribing information]. Skillman, NJ: Johnson and Johnson; received January 2021.
  3. Rogaine Men's solution (minoxidil) [prescribing information]. Skillman, NJ: Johnson and Johnson; received January 2021.
  4. Rogaine Women's foam (minoxidil) [prescribing information]. Newbrunswick, NJ: Johnson and Johnson; received February 2020.
  5. Rogaine Women's solution (minoxidil) [prescribing information]. Newbrunswick, NJ: Johnson and Johnson; no date.
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