ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
medimedia.ir

Malathion: Drug information

Malathion: Drug information
(For additional information see "Malathion: Patient drug information" and see "Malathion: Pediatric drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Ovide
Pharmacologic Category
  • Antiparasitic Agent, Topical;
  • Pediculocide;
  • Scabicidal Agent
Dosing: Adult
Head lice

Head lice (Pediculus humanus capitis): Topical: Apply sufficient amount to cover and thoroughly moisten dry hair and scalp; allow hair to dry naturally and shampoo after 8 to 12 hours. If required, repeat with second application in 7 to 9 days. Further treatment is generally not necessary.

Pubic lice

Pubic lice (Pediculosis pubis) (following treatment failure of pediculicides) (off-label use): Topical: Apply to affected area. Wash off after 8 to12 hours (CDC [Workowski 2021]).

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

(For additional information see "Malathion: Pediatric drug information")

Head lice

Head lice:

Children 2 to 5 years: Limited data available: Note: Only use for head lice resistant to permethrin/pyrethrins or previously failed courses: Topical: Apply sufficient amount to cover and thoroughly moisten dry hair and scalp, leave on for 8 to 12 hours (typically overnight application); may shampoo upon completion; during clinical trials, a maximum dose of ~60 mL (2 fl oz) was used (AAP [Devore 2015]). Note: In a blinded, comparative trial with permethrin in older children, a shorter application time of 20 minutes was shown effective (AAP [Devore 2015]; Meinking 2004). Further treatment is generally not necessary.

Children ≥6 years and Adolescents: Topical: Apply sufficient amount to cover and thoroughly moisten dry hair and scalp, leave on for 8 to 12 hours (typically overnight application); may shampoo upon completion; if live lice are observed 7 to 9 days after application, reapply product; during clinical trials, a maximum dose of ~60 mL (2 fl oz) was used. Note: In a blinded, comparative trial with permethrin, a shorter application time of 20 minutes was shown effective (AAP [Devore 2015]; Meinking 2004). Further treatment is generally not necessary.

Pubic lice resistant to permethrin/pyrethrins or previously failed courses

Pubic lice (Pediculosis pubis) resistant to permethrin/pyrethrins or previously failed courses: Limited data available: Adolescents: Topical: Apply to affected area. Wash off after 8 to12 hours (CDC [Workowski 2015])

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer’s labeling.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Frequency not defined.

Dermatologic: Skin irritation (including scalp irritation), stinging of the skin

Ophthalmic: Conjunctivitis (following contact with eyes)

Miscellaneous: Burn (chemical; including second-degree burns)

Contraindications

Hypersensitivity to malathion or any component of the formulation; use in neonates and/or infants

Warnings/Precautions

Concerns related to adverse effects:

• Dermatologic effects: Discontinue use temporarily if skin irritation occurs. Chemical burns, including second-degree burns, and stinging sensations may occur with use.

Other warnings/precautions:

• Appropriate use: For topical use on scalp hair only; leave hair uncovered after application (allow hair to dry naturally). Avoid contact with eyes; flush immediately with water if eye contact occurs. Wash hands immediately after application.

• Flammable: Lotion is flammable; do not expose lotion or hair wetted with malathion to open flames or electric heat sources (eg, hair dryer, curling iron, flat iron). Do not smoke while applying lotion or while hair is wet.

Warnings: Additional Pediatric Considerations

Systemic absorption may be increased in infants and neonates due to higher skin surface area to body mass ratio and immature skin barrier; risk for malathion toxicity potentially increased; use is contraindicated in these patients.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Lotion, External:

Ovide: 0.5% (59 mL) [contains isopropyl alcohol]

Generic: 0.5% (59 mL)

Generic Equivalent Available: US

Yes

Pricing: US

Lotion (Malathion External)

0.5% (per mL): $4.51

Lotion (Ovide External)

0.5% (per mL): $5.22

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Administration: Adult

Topical lotion. For external use only; avoid contact with eyes. Apply to dry hair and scalp and rub gently until thoroughly moistened; pay special attention to the back of the head and neck. Allow hair to dry naturally; do not use heat; leave hair uncovered. After 8-12 hours, the hair should be washed with a nonmedicated shampoo; rinse and use a fine-toothed (nit) comb to remove dead lice and eggs. Evaluate other family members to determine if infested and require treatment. Wash hands immediately after use.

Malathion should be a portion of a whole household lice removal program, which should include washing or dry cleaning all clothing, hats, bedding, and towels recently worn or used by the patient and washing combs, brushes, and hair accessories in hot soapy water.

Administration: Pediatric

Topical: For external use only; avoid contact with eyes. Apply to dry hair and scalp and rub gently until thoroughly moistened; pay special attention to the back of the head and neck. Allow hair to dry naturally; do not use heat; leave hair uncovered; after 8 to 12 hours, wash hair with a nonmedicated shampoo; rinse and use a fine-toothed (nit) comb to remove dead lice and eggs. Wash hands immediately after use.

Malathion should be a portion of a whole lice removal program, which should include washing or dry cleaning all clothing, hats, bedding, and towels recently worn or used by the patient and washing combs, brushes, and hair accessories in hot, soapy water.

Use: Labeled Indications

Head lice infection: Topical treatment of Pediculus humanus capitis (head lice and their ova) of the scalp hair

Use: Off-Label: Adult

Pubic lice (Pediculosis pubis)

Medication Safety Issues
Pediatric patients: High-risk medication:

KIDs List: Malathion, when used in infants <1 year of age, is identified on the Key Potentially Inappropriate Drugs in Pediatrics (KIDs) list and should be avoided due to risk of increased absorption (organophosphate poisoning) (weak recommendation; very low quality of evidence) (PPA [Meyers 2020]).

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Pregnancy Considerations

Agents other than malathion are recommended for the treatment of pediculosis pubis during pregnancy (CDC [Workowski 2021]).

Breastfeeding Considerations

It is not known if malathion is present in breast milk following topical use of the 0.5% lotion.

Use with caution if administered to or handled by breastfeeding patients.

Mechanism of Action

Organophosphate that acts as a pediculicide by inhibiting cholinesterase activity in Pediculus humanus capitis (head lice and their ova)

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Prioderm;
  • (AU) Australia: Chemists own hlt | Gold cross exolice | Kp24 | Lice rid | Malathion headlice | Nick of nits;
  • (BE) Belgium: Prioderm | Radikal;
  • (EG) Egypt: Lice clean | Prioderm | Quick;
  • (FI) Finland: Prioderm;
  • (FR) France: Prioderm;
  • (GB) United Kingdom: Derbac m | Prioderm;
  • (GR) Greece: Sicaril | Specifthir | Zitotox;
  • (HK) Hong Kong: Licecare;
  • (IE) Ireland: Derbac m | Prioderm;
  • (KW) Kuwait: Prioderm;
  • (LU) Luxembourg: Prioderm | Radikal;
  • (NL) Netherlands: Noury | Prioderm;
  • (NO) Norway: Malation | Prioderm;
  • (NZ) New Zealand: Derbac m;
  • (PR) Puerto Rico: Ovide;
  • (SG) Singapore: Derbac m | Lice Care | Prioderm;
  • (UY) Uruguay: Piojisar M
  1. Devore CD, Schutze GE; Council on School Health and Committee on Infectious Diseases, American Academy of Pediatrics. Head lice. Pediatrics. 2015;135(5):e1355-e1365. [PubMed 25917986]
  2. “Drugs for Parasitic Infections,” Med Lett Drugs Ther, 1993, 35(911):111-22. [PubMed 8246830]
  3. Frankowski BL and Bocchini JA Jr, “Head Lice,” Pediatrics, 2010, 126(2):392-403. [PubMed 20660553]
  4. Meinking TL, Vicaria M, Eyerdam DH, et al, "Efficacy of a Reduced Application Time of Ovide Lotion (0.5% Malathion) Compared to Nix Creme Rinse (1% Permethrin) for the Treatment of Head Lice," Pediatr Dermatol, 2004, 21(6):670-4. [PubMed 15575855]
  5. Meyers RS, Thackray J, Matson KL, et al. Key Potentially Inappropriate Drugs in Pediatrics: The KIDs List. J Pediatr Pharmacol Ther. 2020;25(3):175-191. [PubMed 32265601]
  6. Ovide 0.5% (malathion lotion) [prescribing information]. Hawthorne, NY: Taro Pharmaceuticals USA, Inc; September 2013.
  7. Workowski KA, Bolan GA; Centers for Disease Control and Prevention (CDC). Sexually transmitted diseases treatment guidelines, 2015 [published correction appears in MMWR Recomm Rep. 2015;64(33):924]. MMWR Recomm Rep. 2015;64(RR-03):1-137. [PubMed 26042815]
  8. Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm Rep. 2021;70(4):1-187. doi:10.15585/mmwr.rr7004a1 [PubMed 34292926]
Topic 9584 Version 133.0

آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟