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College of American Pathologists classification system for uterine sarcomas

College of American Pathologists classification system for uterine sarcomas
Histologic type (more than one may apply)
Leiomyosarcoma
  • Not otherwise specified
  • Spindle (conventional)
  • Epithelioid
  • Myxoid
Endometrial stromal sarcoma, low grade*
Endometrial stromal sarcoma, high grade
Undifferentiated sarcoma
Adenosarcoma
  • Not otherwise specified
  • With sarcomatous overgrowth
Rhabdomyosarcoma
Malignant perivascular epithelioid cell tumor
Other (specify)
* Low-grade endometrial stromal sarcoma is distinguished from a benign endometrial stromal nodule by depth of myometrial invasion greater than or equal to 3 mm, lymphovascular invasion, or greater than or equal to 3 foci of myometrial invasion of any depth. Minor marginal irregularity in the form of tongues less than 3 mm is allowable for an endometrial stromal nodule. This checklist does not apply to endometrial stromal nodules.
Adapted from: Krishnamurti UG, Crothers BA. Protocol for the examination of specimens from patients with primary sarcoma of the uterus. College of American Pathologists 2022. Available at: https://documents.cap.org/protocols/Uterus.Sarc_4.4.0.0.REL_CAPCP.pdf (Accessed on December 20, 2022).
Graphic 95022 Version 3.0

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