Diagnostic criteria for logopenic variant PPA

I. Clinical diagnosis of logopenic variant PPA

Both of the following core features must be present:

Impaired single-word retrieval in spontaneous speech and naming
Impaired repetition of sentences and phrases

At least 3 of the following other features must be present:

Speech (phonologic) errors in spontaneous speech and naming
Spared single-word comprehension and object knowledge
Spared motor speech
Absence of frank agrammatism

II. Imaging-supported diagnosis of logopenic variant PPA

Both criteria must be present:

Clinical diagnosis of logopenic variant PPA
Imaging must show at least one of the following results:
1. Predominant left posterior perisylvian or parietal atrophy on MRI
2. Predominant left posterior perisylvian or parietal hypoperfusion or hypometabolism on SPECT or PET

III. Logopenic variant PPA with definite pathology

Clinical diagnosis (criterion 1 below) and either criterion 2 or 3 must be present:

Clinical diagnosis of logopenic variant PPA
Histopathologic evidence of a specific neurodegenerative pathology (eg, AD, FTLD-tau, FTLD-TDP, other)
Presence of a known pathogenic mutation

AD: Alzheimer disease; FTLD: frontotemporal lobar degeneration; MRI: magnetic resonance imaging; PET: positron emission tomography; PPA: primary progressive aphasia; SPECT: single-photon emission computed tomography; TDP: TAR DNA-binding protein 43.

From: Gorno-Tempini ML, Hillis AE, Weintraub S, et al. Classification of primary progressive aphasia and its variants. Neurology 2011; 76:1006. DOI: 10.1212/WNL.0b013e31821103e6. Copyright © 2011 American Academy of Neurology. Reproduced with permission from Lippincott Williams & Wilkins. Unauthorized reproduction of this material is prohibited.

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Diagnostic criteria for logopenic variant PPA