A. Evidence of significant cognitive decline from a previous level of performance in one or more cognitive domains*: |
Learning and memory. |
Language. |
Executive function. |
Complex attention. |
Perceptual-motor. |
Social cognition. |
B. The cognitive deficits interfere with independence in everyday activities. At a minimum, assistance should be required with complex instrumental activities of daily living, such as paying bills or managing medications. |
C. The cognitive deficits do not occur exclusively in the context of a delirium. |
D. The cognitive deficits are not better explained by another mental disorder (eg, major depressive disorder, schizophrenia). |
E. There is insidious onset and gradual progression of impairment in at least two cognitive domains. |
F. Either of the following: |
Evidence of a causative Alzheimer disease genetic mutation from family history or genetic testing. |
All three of the following are present: |
1) Clear evidence of decline in memory and learning and at least one other cognitive domain. |
2) Steadily progressive, gradual decline in cognition, without extended plateaus. |
3) No evidence of mixed etiology (ie, absence of other neurodegenerative disorders or cerebrovascular disease, or another neurological, mental, or systemic disease or condition likely contributing to cognitive decline). |
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