Drug class | Drug | Brand name(s) | PT | aPTT | Anti-factor Xa activity |
Vitamin K antagonists | Warfarin | Jantoven | ↑ | ↑/– * | – |
Acenocoumarol | Sintrom | ↑ | ↑/– * | – | |
Heparins | Unfractionated heparin | – ¶ | ↑ | ↑ | |
LMW heparins | – | ↑/– | ↑ | ||
Enoxaparin | Lovenox | ||||
Dalteparin | Fragmin | ||||
Nadroparin | Fraxiparine | ||||
Fondaparinux | Arixtra | – | ↑/– | ↑ | |
Direct thrombin inhibitors | Argatroban | Acova | ↑ | ↑ | – |
Dabigatran | Pradaxa | ↑/– | ↑ | – | |
Direct factor Xa inhibitors | Rivaroxaban | Xarelto | ↑/– | ↑/– | ↑Δ |
Apixaban | Eliquis | ↑/– | ↑/– | ↑Δ | |
Edoxaban | Lixiana, Savaysa | ↑Δ |
PT: prothrombin time; aPTT: activated partial thromboplastin time; LMW heparin: low molecular weight heparin.
* Warfarin has a weak effect on most aPTT reagents. However, warfarin use will increase the sensitivity of the aPTT to heparin effect.
¶ While heparin, LMW heparin, and fondaparinux should, in theory, prolong the PT as indirect thrombin inhibitors, in practice most PT reagents contain heparin-binding chemicals that block any heparin effect below a concentration of 1 unit/mL. Above concentrations of 1 unit/mL, heparin effect on the PT may be observed.
Δ Anti-factor Xa activity testing must be calibrated for the specific anticoagulant; this information should be verified with the clinical laboratory.آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟