NCI CTCAE v5.0 acute kidney injury, creatinine increased

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Acute kidney injury			Hospitalization indicated	Life-threatening consequences; dialysis indicated	Death
Creatinine increased	>ULN to 1.5 x ULN	>1.5 to 3.0 x baseline; >1.5 to 3.0 x ULN	>3.0 x baseline; >3.0 to 6.0 x ULN	>6.0 x ULN

Acute kidney injury is characterized by the acute loss of renal function (within two weeks) and is traditionally classified as pre-renal (low blood flow into the kidney), renal (kidney damage), and post-renal causes (ureteral or bladder outflow obstruction). Creatinine increased is a laboratory test result of increased creatinine in a biological specimen (graded under "Investigations").

NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events; ULN: upper limit of normal.

Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed March 27, 2018).

Graphic 91253 Version 4.0

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NCI CTCAE v5.0 acute kidney injury, creatinine increased