NCI CTCAE v5.0 allergic reaction and anaphylaxis

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Allergic reaction	Systemic intervention not indicated	Oral intervention indicated	Bronchospasm; hospitalization indicated for clinical sequelae; intravenous intervention indicated	Life-threatening consequences; urgent intervention indicated	Death
Anaphylaxis			Symptomatic bronchospasm, with or without urticaria; parenteral intervention indicated; allergy-related edema/angioedema; hypotension	Life-threatening consequences; urgent intervention indicated	Death

Allergic reactions are characterized by adverse local or general responses from exposure to an allergen. NOTE: If related to a drug infusion, use the grading scheme for infusion-related reaction.
Anaphylaxis is characterized by an acute inflammatory reaction resulting from the release of histamine and histamine-like substances from mast cells, causing a hypersensitivity immune response. Clinically, it presents with breathing difficulty, dizziness, hypotension, cyanosis, and loss of consciousness and may lead to death.

NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events; NSAIDS: non-steroidal anti-inflammatory drugs.

Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed March 27, 2018).

Graphic 91249 Version 5.0

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NCI CTCAE v5.0 allergic reaction and anaphylaxis