NCI CTCAE v5.0 infusion site extravasation

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Infusion site extravasation	Painless edema	Erythema with associated symptoms (eg, edema, pain, induration, phlebitis)	Ulceration or necrosis, severe tissue damage; operative intervention indicated	Life-threatening consequences; urgent intervention indicated	Death

Infusion site extravasation is characterized by leakage of the infusion into the surrounding tissue. Signs and symptoms include induration, erythema, swelling, burning sensation, and marked discomfort at the infusion site.

NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events.

Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed March 27, 2018).

Graphic 91248 Version 3.0

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NCI CTCAE v5.0 infusion site extravasation