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Survival following allogeneic hematopoietic cell transplantation based on the degree of HLA matching

Survival following allogeneic hematopoietic cell transplantation based on the degree of HLA matching
Survival of patients with early, intermediate, and advanced disease depending on degree of HLA matching (8/8, 7/8, and 6/8) for HLA-A, -B, -C, and -DRB1.
(A) Early-stage disease for 8/8, 7/8, and 6/8, respectively: one-year survival 63, 52, and 39 percent; five-year survival 50, 39, and 28 percent.
(B) Intermediate-stage disease for 8/8, 7/8, and 6/8, respectively: one-year survival 48, 40, and 32 percent; five-year survival 32, 27, and 22 percent.
(C) Advanced-stage disease for 8/8, 7/8, and 6/8, respectively: one-year survival 31, 29, and 24 percent; five-year survival 17, 15, and 10 percent.
HLA: human leukocyte antigen.
Reproduced with permission of the American Society of Hematology, from Lee SJ, Klein J, Haagenson M, et al. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood 2007; 110:4576; permission conveyed through Copyright Clearance Center, Inc.
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