Drugs associated with Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN)

Strongly associated*

Associated^Δ

Suspected association/lower risk^◊

Agents are presented in order of decreasing number of cases included in the European Registry (RegiSCAR).

NSAID: nonsteroidal anti-inflammatory drug; RegiSCAR: International Registry of Severe Cutaneous Adverse Reactions.

* Significant association in case-control studies with a lower limit of the confidence interval ≥5 and unpublished data from the RegiSCAR.

¶ Etoricoxib, tenoxicam, and dipyrone are NSAIDs available in some countries outside of North America.

Δ Significant association in case-control studies with a lower limit of the confidence interval <5.

◊ Some cases with plausible causality in medical literature and/or RegiSCAR European Registry.

§ Tetrazepam is a benzodiazepine available in some countries outside North America and Europe.

Data from: The RegiSCAR Project. Available at: http://www.regiscar.org/index.html (Accessed on April 4, 2018).

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