Version May 2024
| Symptoms |
| Anorexia |
| Weight loss |
| Weakness |
| Fatigue |
| Muscle cramps |
| Easy bruising |
| Amenorrhea/oligomenorrhea/metrorrhagia (women) |
| Impotence (men) |
| Infertility |
| Decreased libido (men) |
| Jaundice* |
| Dark or "cola-colored" urine* |
| Pruritus* |
| Hematemesis/melena/hematochezia* |
| Abdominal distension* |
| Lower extremity edema* |
| Confusion or sleep disturbances* |
| Physical examination |
| Hepatomegaly |
| Splenomegaly |
| Spider angiomata/spider telangiectasias |
| Palmar erythema |
| Digital clubbing |
| Hypertrophic osteoarthropathy |
| Dupuytren's contracture |
| Muehrcke nails |
| Terry nails |
| Parotid gland enlargement (likely due to alcohol use and not cirrhosis per se) |
| Gynecomastia (men) |
| Loss of chest or axillary hair (men) |
| Testicular atrophy (men) |
| Caput medusa |
| Cruveilhier-Baumgarten murmur (venous hum heard best with the stethoscope over the epigastrium) |
| Jaundice* |
| Ascites (abdominal distension, shifting dullness, fluid wave)* |
| Asterixis* |
| Fetor hepaticus* |
| Laboratory tests |
| Moderately elevated aminotransferases (often with an AST:ALT ratio >1) |
| Elevated alkaline phosphatase (2 to 3 times the ULN) |
| Elevated gamma-glutamyl transpeptidase |
| Thrombocytopenia |
| Leukopenia/neutropenia |
| Anemia |
| Low serum albumin* |
| Prolonged prothrombin time/elevated INR* |
| Hyperbilirubinemia* |
| Hyponatremia* |
| Elevated serum creatinine* |
| Imaging tests |
| Surface nodularity |
| Increased echogenicity (ultrasound) |
| Atrophy of the right lobe |
| Hypertrophy of the caudate or left lobes |
| Small, nodular liver* |
| Ascites* |
| Hepatocellular carcinoma* |
| Portal/splenic/superior mesenteric vein thrombosis* |
| Portosystemic collaterals* |
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