Frequency of patch test positivity for preservatives

Preservative	NACDG 2015 to 2016 reactions (percent)
Methylisothiazolinone	13.4
Formaldehyde	8.4
MCI/MI	7.3
Iodopropynyl butylcarbamate	3.9
Quaternium 15	3.6
Methyldibromo glutaronitrile	3.5
2-bromo-2-nitropropane-1,3-diol	1.3
Diazolidinyl urea	1.2
Imidazolidinyl urea	1.1
DMDM hydantoin	0.8
Parabens	0.6

NACDG: North American Contact Dermatitis Group; MCI/MI: methylchloroisothiazolinone/methylisothiazolinone.

Data from: DeKoven JG, Warshaw EM, Zug KA, et al. North American Contact Dermatitis Group Patch Test Results: 2015-2016. Dermatitis 2018; 29:297.

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