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Gene expression assays available in the United States for clinical use in stage II colon cancer

Gene expression assays available in the United States for clinical use in stage II colon cancer
Assay Company Gene signature Specimen used
ColoPrint colon cancer recurrence assay* Agendia, Inc 18 gene expression profile (using agilent microarray) Fresh tissue or fresh, frozen tissue
ColonPRS Signal Genetics, LLC 163 genes Fresh, frozen biopsies
GeneFx colon Licensed by Precision Therapeutics (originally developed by Almac Diagnostics as the ColDX assay) 634 probe-set signature Formalin-fixed paraffin embedded tissue
OncoDefender-CRC (colon and rectal cancer) Everist Genomics 5 genes Formalin-fixed paraffin embedded tissue
Oncotype DX colon cancer assay Genomic Health, Inc 12 genes (seven prognostic and five reference genes) Formalin-fixed paraffin embedded tissue
* May also be available for use through PARSC clinical trial.
¶ Currently available for nondiagnostic or research use only.
Reproduced from: Black ER, Falzon L, Aronson N. Gene Expression Profiling for Predicting Outcomes in Stage II Colon Cancer. Technical Brief. No. 13. (Prepared by the Blue Cross and Blue Shield Association Technology Evaluation Center Evidence-based Practice Center under Contract No. 290-2007-0058-I.) Rockville, MD: Agency for Healthcare Research and Quality. December 2012. www.effectivehealthcare.ahrq.gov/reports/final.cfm.
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