NSAIDs block the vasodilatory effect of prostaglandins on the afferent arteriole and reduce GFR

Certain conditions that promote renal vasoconstriction and renal hypoperfusion require prostaglandins to vasodilate the afferent arteriole and blunt vasoconstriction to maintain a normal GFR (left). However in the presence of NSAIDs, which reduced prostaglandin production, afferent arteriole vasoconstriction dominates and reduces GFR (right).