Antibody | Clinical features of associated neuropathy | Associated systemic disease |
GM1 | Multifocal motor neuropathy; may also be elevated in motor neuron disease, Guillain-Barré syndrome and its variants | None |
MAG; SGPG | Demyelinating neuropathy, most often with distal predominantly sensory symptoms (DADS phenotype) | IgM monoclonal gammopathy of undetermined significance (MGUS) |
GQ1b | Miller Fisher syndrome; Bickerstaff encephalitis, pharyngeal-cervical-brachial weakness; "anti-GQ1b antibody syndrome" | None |
GD1a | Axonal Guillain-Barré syndrome | |
GD1b | Sensory-predominant neuropathy; motor neuron disease; Guillain-Barré syndrome | None |
Sulfatide | Sensory-predominant neuropathy | None |
Galopin (IgM kappa) | Gait ataxia with late onset polyneuropathy (GALOP) syndrome | None |
Hu (ANNA-1) | Sensory neuronopathy; autonomic and sensorimotor polyneuropathy | Cancer, typically small-cell lung cancer (SCLC). May also be associated with limbic encephalitis. |
CV2/CRMP-5; amphiphysin; Ri (ANNA-2), ANNA-3; N-type calcium channel antibodies | Sensorimotor polyneuropathy | Cancer, typically SCLC, thymoma, breast cancer. Antibodies are associated with other neurologic syndromes including limbic encephalitis. |
C-ANCA; P-ANCA | Painful mononeuritis multiplex; distal symmetric polyneuropathy less common | Systemic vasculitis: Churg-Strauss; polyarteritis nodosa; granulomatosis with polyangiitis (Wegener) |
ANA; RF | Painful neuropathy; mononeuritis multiplex | Rheumatoid arthritis; systemic vasculitis |
Ro/SSA; La/SSB | Painful sensory, predominantly small-fiber, neuropathy; sensory neuronopathy | Sjögren syndrome |
Gliadin; endomysial; tTG (tissue trans-glutaminase) | Mild distal sensory polyneuropathy | Celiac disease |
Contactin-1 | Subacute neuropathy with ataxia and cranial nerve impairments | None |
Neurofascin-155 | Distal-predominating neuropathy with sensory ataxia and tremor | None |
Contactin-associated protein 1 | Acute or subacute sensory neuropathy with ataxia, cranial nerve impairments, tremor, and neuropathic pain | None |
Neurofascin 140/186 | Severe motor neuropathy with cranial nerve and respiratory involvement, dysautonomia, and nephrotic syndrome | None |
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