Version May 2024
Dry eye syndromes (moderate to severe): Ophthalmic: Insert once daily into the inferior cul-de-sac beneath the base of tarsus; some may require twice daily use.
There are no dosage adjustments provided in the manufacturer’s labeling. However, dosage adjustment unlikely due to low systemic absorption.
There are no dosage adjustments provided in the manufacturer’s labeling. However, dosage adjustment unlikely due to low systemic absorption.
Refer to adult dosing.
The following adverse drug reactions are derived from product labeling unless otherwise specified.
Postmarketing:
Cardiovascular: Hyperemia
Hypersensitivity: Hypersensitivity reaction
Ophthalmic: Blurred vision (transient), eye discomfort, eye irritation, eyelid edema, matting or stickiness of eyelashes, photophobia
Hypersensitivity to hydroxypropyl cellulose or any component of the formulation
Concerns related to adverse events:
• Corneal abrasion: May result in corneal abrasion if improperly placed in eye.
• Ophthalmic effects: May cause transient blurring of vision; exercise caution when operating machinery or driving. Removing insert for a few hours may alleviate transient blurred vision.
Other warnings/precautions:
• Appropriate use: Ensure proper placement of insert; if not properly positioned, the insert will be expelled into the interpalpebral fissure and may cause symptoms of a foreign body. Occasionally, insert may be inadvertently expelled from the eye, especially in patients with shallow conjunctival fornices. If insert is dislodged or expelled, another insert may be inserted. If worsening of symptoms occurs, inspect the conjunctival sac to ensure proper placement of insert; if symptoms persist, remove the insert and contact a health care provider.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Insert, Ophthalmic [preservative free]:
Lacrisert: 5 mg (60 ea)
No
INST (Lacrisert Ophthalmic)
5 mg (per each): $11.94
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Insert ophthalmically into the inferior cul-de-sac beneath the base of tarsus (not in apposition to the cornea nor beneath the eyelid at the level of the tarsal plate)
Dry eye syndromes (moderate to severe): Moderate to severe dry eye syndromes, including keratoconjunctivitis sicca (especially in patients who remain symptomatic after an adequate trial of artificial tear solutions); exposure keratitis; decreased corneal sensitivity; recurrent corneal erosions
None known.
There are no known significant interactions.
Hydroxypropyl cellulose is physiologically inert and is not metabolized. It was not absorbed following oral administration in animal studies. Systemic absorption would be required in order for hydroxypropyl cellulose to cross the placenta and reach the fetus.
Stabilizes and thickens the precorneal tear film and prolongs tear film breakup time, which is usually accelerated in patients with dry eye states; also acts to lubricate and protect the eye
Duration of action: Up to 24 hours
Absorption: Not absorbed
Excretion: Feces
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