The contribution of C1INH to protease inhibition in plasma

Protease	% of plasma inhibitory capacity provided by C1INH
Complement system
C1r	100
C1s	100
MASP2	*
Contact system
Plasma kallikrein	42 to 84
Coagulation factor XIa	47
Coagulation factor XIIa	90
Fibrinolytic system
Tissue plasminogen activator	¶
Plasmin	¶

C1INH: C1 inhibitor; MASP2: mannose-associated serine protease 2.
* Undetermined; probably the primary inhibitor; alpha₂-macroglobulin may play some role.
¶ C1INH plays little (if any) role under normal circumstances, but small amounts of complexes with tissue plasminogen activator and plasmin may be observed in some situations (angioedema attacks, endotoxin shock, and exhaustive exercise).

Reproduced from: Davis AE III. Hereditary angioedema: a current state-of-the art review, III: Mechanisms of hereditary angioedema. Ann Allergy Asthma Immunol 2008; 100 (Suppl 2):S7. Table used with the permission of Elsevier Inc. All rights reserved.

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The contribution of C1INH to protease inhibition in plasma