Standardized Incidence Ratios (SIRs) for secondary sarcoma after any first cancer according to RT and age at first cancer diagnosis, SEER 9 (1973-2008)

Age at first cancer diagnosis	Bone sarcoma				Soft tissue sarcoma
	RT		No RT		RT		No RT
	Obs	SIR	Obs	SIR	Obs	SIR	Obs	SIR
20 to 39 years	13	4.40*	10	1.31	52	5.32*	58	2.25*
40 to 59 years	42	3.71*	40	1.23	129	2.41*	219	1.37*
60 to 79 years	40	2.60*	57	1.31	177	1.83*	302	1.15*

Analysis includes adulthood (age 20 to 79 years at diagnosis) greater than one year survivors of any first cancer (excluding bone sarcoma or soft tissue sarcoma, respectively). Follow-up for second primary bone or soft tissue sarcoma continued to age 85 years. Patients with unknown radiotherapy were excluded.

Obs: observed number of subsequent primary sarcomas; RT: radiotherapy.
* p<0.05.

Reproduced from: Berrington de Gonzalez A, Kutsenko A, Rajaraman P. Sarcoma risk after radiation exposure. Clin Sarcoma Res 2012; 2:18. Copyright © 2012 Berrington de Gonzalez et al and BioMed Central Ltd.

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Standardized Incidence Ratios (SIRs) for secondary sarcoma after any first cancer according to RT and age at first cancer diagnosis, SEER 9 (1973-2008)