Standardized Incidence Ratios (SIRs) for subsequent sarcoma after any first cancer in adulthood according to RT versus no RT, and time since first cancer diagnosis, SEER 9 (1973-2008)

Time since first cancer diagnosis	Bone sarcoma				Soft tissue sarcoma
	RT		No RT		RT		No RT
	Obs	SIR	Obs	SIR	Obs	SIR	Obs	SIR
1 to 4 years	34	1.49*	77	1.32*	135	1.22*	311	1.15*
5 to 9 years	43	2.74*	56	1.24	185	2.22*	271	1.21*
10 to 14 years	23	3.23*	34	1.31	78	2.04*	141	1.06
15+ years	23	4.35*	24	0.94	62	2.20*	159	1.21*
Total	123	2.42*	191	1.23*	460	1.77*	882	1.16*

Analysis includes adulthood (age 20 to 79 years at diagnosis) greater than one year survivors of any first cancer (excluding bone sarcoma or soft tissue sarcoma, respectively). Follow-up for second primary bone or soft tissue sarcoma continued to age 85 years. Patients with unknown radiotherapy were excluded.

Obs: observed number of subsequent primary sarcomas; RT: radiotherapy.
* p<0.05.

Reproduced from: Berrington de Gonzalez A, Kutsenko A, Rajaraman P. Sarcoma risk after radiation exposure. Clin Sarcoma Res 2012; 2:18. Copyright © 2012 Berrington de Gonzalez et al and BioMed Central Ltd.

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Standardized Incidence Ratios (SIRs) for subsequent sarcoma after any first cancer in adulthood according to RT versus no RT, and time since first cancer diagnosis, SEER 9 (1973-2008)