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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد

Frequency of extraintestinal manifestations in pediatric patients with inflammatory bowel disease

Frequency of extraintestinal manifestations in pediatric patients with inflammatory bowel disease
  Total
n (%)		 Crohn disease
n (%)		 Ulcerative colitis
n (%)
Total 1009 728 281
Any extraintestinal manifestation* 285 (28.2) 218 (29.9) 67 (23.8)
Arthralgia 166 (16.5) 124 (17) 42 (14.9)
Aphthous stomatitis 81 (8) 72 (9.9) 9 (3.2)
Arthritis 37 (3.7) 32 (4.4) 5 (1.8)
Erythema nodosum 28 (2.8) 26 (3.6)Δ 2 (0.71)Δ
Primary sclerosing cholangitis 15 (1.5) 7 (1)◊ 8 (2.8)◊§
Pancreatitis 9 (0.9) 5 (0.7) 4 (1.4)
Chronic active hepatitis 6 (0.6) 2 (0.3) 4 (1.4)
Iritis or uveitis 7 (0.7) 6 (0.8) 1 (0.4)
Ankylosing spondylitis 4 (0.4) 4 (0.5) 0
Pyoderma gangrenosum 3 (0.3) 3 (0.4) 0
Fever and fatigue are also common in inflammatory bowel disease but were not specifically tracked in this study.

* Number of individual subjects with one or more extraintestinal manifestations.

¶ p<0.001 for Crohn disease versus ulcerative colitis.

Δ p<0.01 for Crohn disease versus ulcerative colitis.

◊ p = 0.039 for Crohn disease versus ulcerative colitis.

§ The prevalence of primary sclerosing cholangitis may be as high as 10% among pediatric patients with ulcerative colitis, according to a study using rigorous case-finding methods[1].
Reference:
  1. Deneau M, Jensen MK, Holmen J, et al. Primary sclerosing cholangitis, autoimmune hepatitis and overlap in Utah children: Epidemiology and natural history. Hepatology 2013.

Reproduced with permission from: Dotson JL, Hyams JS, Markowitz J, et al. Extraintestinal manifestations of pediatric inflammatory bowel disease and their relation to disease type and severity. J Pediatr Gastroenterol Nutr 2010; 51:140. DOI: 10.1097/MPG.0b013e3181ca4db4. Copyright © 2010 ESPGHAN and NASPGHAN. Unauthorized reproduction of this material is prohibited.

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