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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
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Key clinical and laboratory findings in pemphigus

Key clinical and laboratory findings in pemphigus
  Epidemiology Autoantigens Clinical features Histopathology Direct immunofluorescence Indirect immunofluorescence ELISA Variants
Pemphigus vulgaris Primarily middle-aged adults Desmoglein 1 and desmoglein 3, others Mucosal erosions; flaccid bullae and erosions on skin Suprabasal acantholysis; "row of tombstones" pattern of basal keratinocytes Intercellular deposition of IgG Intercellular deposition of IgG; monkey esophagus is preferred substrate Desmoglein 3 or both desmoglein 1 and desmoglein 3 autoantibodies Pemphigus vegetans and pemphigus herpetiformis
Pemphigus foliaceus Primarily middle-aged adults; endemic form most common in children and young adults Desmoglein 1 Fragile blisters, shallow erosions, erythematous patches, crusts; mucosal involvement absent Subcorneal or granular layer acantholysis Intercellular deposition of IgG Intercellular deposition of IgG; normal human skin or guinea pig esophagus is preferred substrate Desmoglein 1 autoantibodies Endemic pemphigus foliaceus (fogo sevalgem), pemphigus erythematosus, and pemphigus herpetiformis
Paraneoplastic pemphigus Primarily adults, but may occur at any age Envoplakin, periplakin, others Severe stomatitis, variable cutaneous findings (eg, blisters, erosions, lichenoid lesions), bronchiolitis obliterans Variable findings; suprabasal acantholysis, keratinocyte necrosis, and lichenoid interface dermatitis are most common Intercellular and/or basement membrane zone deposition of IgG and/or C3 Intercellular deposition of IgG; rat bladder is preferred substrate Envoplakin and periplakin autoantibodies  
IgA pemphigus
Subcorneal pustular dermatosis-type IgA pemphigus Any age Desmocollin 1 Vesicles, pustules, crusts on skin; annular, circinate, or herpetiform morphology; mucosal involvement usually absent Subcorneal clefts and pustules; minimal acantholysis; mixed infiltrate in dermis Intercellular deposition of IgA Intercellular deposits of IgA on monkey esophagus* Desmocollin 1 autoantibodies  
Intraepidermal neutrophilic dermatosis Any age Poorly defined Vesicles, pustules, crusts on skin; annular, circinate, or herpetiform morphology; mucosal involvement usually absent Intraepidermal pustules; minimal acantholysis; mixed infiltrate in dermis Intercellular deposition of IgA Intercellular deposits of IgA on monkey esophagus* Desmoglein 1 and 3 autoantibodies have been reported in some patients  
* Indirect immunofluorescence is negative in around 50% of patients with IgA pemphigus.
¶ Test availability restricted to specialized laboratories.
Graphic 87920 Version 4.0

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