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Ampicillin: Drug information

Ampicillin: Drug information
(For additional information see "Ampicillin: Patient drug information" and see "Ampicillin: Pediatric drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: Canada
  • NOVO-Ampicillin
Pharmacologic Category
  • Antibiotic, Penicillin
Dosing: Adult

Dosage guidance:

Clinical consideration: For oral therapy, including oral step-down therapy after IV ampicillin, oral amoxicillin is usually preferred over oral ampicillin due to improved bioavailability and absorption (bioavailability 77% versus 39% to 54%, respectively) (Ref).

Dosing: For ease of outpatient IV ampicillin administration, the total daily dose may be administered as a 24-hour continuous infusion (Ref).

Bloodstream infection

Bloodstream infection :

Pathogen-directed therapy for Enterococcus spp.: IV: 2 g every 4 hours; use as part of an appropriate combination regimen in the setting of suspected endocarditis or critical illness (Ref). Duration of therapy is 7 to 14 days for uncomplicated infection (ie, fever resolution within 72 hours and absence of metastatic focus of infection or endovascular hardware) (Ref). Some experts recommend a duration of 5 to 7 days for uncomplicated infection with rapid blood culture clearance (within 24 hours) and in the absence of metastatic infection (Ref).

Pathogen-directed therapy for Listeria monocytogenes: IV: 2 g every 4 hours; use in combination with gentamicin for nonpregnant patients. Duration should be individualized based on patient factors, source and extent of infection, and clinical response, but ampicillin is usually continued for at least 14 to 21 days (Ref).

Endocarditis, prophylaxis

Endocarditis, prophylaxis (dental or invasive respiratory tract procedures) (alternative agent for patients unable to take oral therapy) (off-label use): IM, IV: 2 g as a single dose 30 to 60 minutes before procedure; if inadvertently not given prior to the procedure, may be administered up to 2 hours after the procedure. Note: Reserve for select situations (cardiac condition with the highest risk of adverse endocarditis outcomes and procedure likely to result in bacteremia with an organism that can cause endocarditis) (Ref).

Endocarditis, treatment

Endocarditis, treatment:

Enterococcus faecalis, native or prosthetic valve (penicillin-susceptible): IV: 2 g every 4 hours as part of an appropriate combination regimen (eg, with ceftriaxone or gentamicin). Duration is usually 6 weeks; for patients with native valve endocarditis and symptoms <3 months, the combination of ampicillin and gentamicin can be given for 4 weeks. Note: Ampicillin plus ceftriaxone is the preferred regimen in patients with or at risk of renal insufficiency or with gentamicin resistance (Ref), and some experts favor this combination for all patients with native valve endocarditis (Ref).

HACEK organisms, native or prosthetic valve (ampicillin-susceptible) (off-label use): IV: 2 g every 4 hours for 4 weeks (native valve) or 6 weeks (prosthetic valve) (Ref). Note: In vitro susceptibility should be confirmed prior to use.

Viridans group streptococci and Streptococcus gallolyticus (Streptococcus bovis) (alternative agent):

Native valve: Highly penicillin-susceptible (minimum inhibitory concentration [MIC] ≤0.12 mcg/mL): IV: 2 g every 4 hours for 4 weeks (Ref).

Native valve: Relatively penicillin-resistant (MIC >0.12 to <0.5 mcg/mL): IV: 2 g every 4 hours for 4 weeks in combination with gentamicin for the first 2 weeks (Ref).

Native valve: Penicillin-resistant (MIC ≥0.5 mcg/mL): IV: 2 g every 4 hours in combination with gentamicin. The duration of this regimen is not well established; infectious diseases consultation recommended (Ref).

Prosthetic valve: Highly penicillin-susceptible (MIC ≤0.12 mcg/mL): IV: 2 g every 4 hours for 6 weeks (with or without concomitant gentamicin for the first 2 weeks) (Ref).

Prosthetic valve: Relatively penicillin-resistant (MIC >0.12 to <0.5 mcg/mL) or fully penicillin-resistant (MIC ≥0.5 mcg/mL): IV: 2 g every 4 hours in combination with gentamicin for 6 weeks (Ref). For relatively resistant strains, some experts prefer a shorter duration of the gentamicin component (≥2 weeks) (Ref).

Intra-abdominal infection, health care–associated

Intra-abdominal infection, health care–associated (off-label use): Empiric or pathogen-directed therapy for Enterococcus spp. in high-risk patients (eg, postoperative infection or healthcare-associated infection in patients with prior use of antibiotics that select for Enterococcus, immunocompromising condition, valvular heart disease, or prosthetic intravascular material):

IV: 2 g every 4 hours as part of an appropriate combination regimen (Ref). Total duration of therapy (which may include transition to oral antibiotics) is 4 to 5 days following adequate source control (Ref).

Meningitis, bacterial

Meningitis, bacterial: As a component of empiric therapy (community-acquired infections in immunocompetent patients >50 years of age and immunocompromised patients) or pathogen-directed therapy (eg, Haemophilus influenzae [beta-lactamase negative], L. monocytogenes, Neisseria meningitidis [penicillin MIC <0.1 mcg/mL], Streptococcus agalactiae, Streptococcus pneumoniae [penicillin MIC ≤0.06 mcg/mL], Enterococcus spp. [ampicillin-susceptible]):

IV: 2 g every 4 hours; for empiric therapy and for directed therapy for Enterococcus or Listeria, use as part of an appropriate combination regimen. Treatment duration is 7 to 21 days, depending on causative pathogen(s) and clinical response (Ref).

Osteomyelitis and/or discitis, treatment

Osteomyelitis and/or discitis, treatment (off-label use): Pathogen-directed therapy for penicillin-susceptible Enterococcus or Streptococcus spp.: IV: 2 g every 4 hours or 12 g as a continuous infusion every 24 hours, generally for ≥6 weeks. Shorter courses are appropriate if the affected bone is completely resected (eg, by amputation) (Ref). For Enterococcus, some experts use with ceftriaxone in the setting of retained hardware (Ref).

Pelvic infections

Pelvic infections (off-label use):

Intra-amniotic infection (chorioamnionitis): IV: 2 g every 6 hours in combination with gentamicin. In females undergoing cesarean delivery, an anti-anaerobic agent should also be added. Continue regimen until vaginal delivery or for 1 dose after cesarean delivery (Ref). Note: Some experts recommend 1 additional dose after vaginal delivery and extension of antibiotics after cesarean delivery until patient is afebrile and asymptomatic ≥48 hours (Ref).

Postpartum endometritis: Note: For patients known to be colonized with GBS (Ref).

IV: 2 g every 6 hours in combination with clindamycin and gentamicin; treat until patient is clinically improved (no fundal tenderness) and afebrile for 24 to 48 hours (Ref).

Tubo-ovarian abscess: IV: 2 g every 6 hours in combination with clindamycin and gentamicin (Ref). After 24 to 48 hours of sustained clinical improvement, may transition to oral therapy to complete 14 days of treatment (Ref).

Peritonitis, treatment

Peritonitis, treatment (peritoneal dialysis patients) (off-label use): Note: Intraperitoneal administration is preferred to IV administration (Ref). Consider a 25% dose increase in patients with significant residual renal function (urine output >100 mL/day) (Ref).

Pathogen-directed therapy (eg, Enterococcus spp., Streptococcus spp.): Continuous (with every exchange): Intraperitoneal: 125 mg/L of dialysate with each exchange (Ref). Duration of therapy is ≥2 weeks for patients with adequate clinical response (Ref).

Prosthetic joint infection

Prosthetic joint infection (off-label use): Pathogen-directed therapy (eg, penicillin-susceptible Enterococcus spp. or Streptococcus spp.): IV: 2 g every 4 hours or 12 g continuous infusion every 24 hours. Duration varies, but is generally 4 to 6 weeks; for enterococcal infections, some experts use with ceftriaxone in the setting of retained hardware (Ref).

Streptococcus, maternal prophylaxis for prevention of neonatal disease

Streptococcus (group B), maternal prophylaxis for prevention of neonatal disease (alternative agent) (off-label use):

IV: 2 g as a single dose at onset of labor or prelabor rupture of membranes, then 1 g every 4 hours until delivery (Ref).

Urinary tract infection

Urinary tract infection:

Note: Uncomplicated urinary tract infection (UTI) has traditionally been defined as infection in an otherwise healthy nonpregnant female with a normal urinary tract; UTI in other patient populations has been considered complicated. Some experts instead categorize UTI as either acute simple cystitis (mild infection limited to the bladder with no signs/symptoms of upper tract or systemic infection in a nonpregnant adult) or complicated UTI (pyelonephritis or cystitis symptoms with other signs/symptoms of systemic infection) (Ref). Ampicillin is not recommended for empiric therapy given decreased efficacy compared to first-line agents and high prevalence of resistance (Ref).

Acute uncomplicated or simple cystitis due to Enterococcus spp.: Oral: 500 mg every 6 hours for 5 to 7 days (Ref).

Acute pyelonephritis or other complicated urinary tract infection due to Enterococcus spp. (off label): IV: 1 to 2 g every 4 to 6 hours; can give with an aminoglycoside for critical illness (Ref). Switch to an appropriate oral regimen once patient has improvement in symptoms. Duration of therapy depends on the antimicrobial chosen to complete the regimen and ranges from 5 to 14 days (Ref).

Dosing: Kidney Impairment: Adult

The renal dosing recommendations are based upon the best available evidence and clinical expertise. Senior Editorial Team: Bruce Mueller, PharmD, FCCP, FASN, FNKF; Jason A. Roberts, PhD, BPharm (Hons), B App Sc, FSHP, FISAC; Michael Heung, MD, MS.

Altered kidney function: IV:

Note: There are no dosage adjustments provided in the manufacturer's labeling and pharmacokinetic data is limited. The following recommendations are based primarily on expert opinion.

Ampicillin Dose Adjustments in Altered Kidney Function

CrCl (mL/minute)

If usual recommended dose is 1 to 2 g every 6 hoursa

If usual recommended dose is 2 g every 4 hoursb

aExpert opinion, Aronoff 2007, Blackwell 1990, Heintz 2009, Wright 1983.

bExpert opinion only.

cDialyzable (39% to 63% [Jusko 1973]); administer after hemodialysis when scheduled dose falls on dialysis days (Heintz 2009).

50 to <130

1 to 2 g every 6 hours

2 g every 4 hours

30 to <50

1 to 2 g every 8 hours

2 g every 6 hours

15 to <30

1 to 2 g every 12 hours

2 g every 8 hours

<15

1 to 2 g every 24 hours

2 g every 12 hours

Hemodialysis, intermittent (thrice weekly)c

1 to 2 g every 24 hours

2 g every 12 hours

Peritoneal dialysis

1 to 2 g every 24 hours

2 g every 12 hours

Augmented renal clearance (measured urinary CrCl ≥130 mL/minute/1.73 m2): Augmented renal clearance (ARC) is a condition that occurs in certain critically ill patients without organ dysfunction and with normal serum creatinine concentrations. Young patients (<55 years of age) admitted post trauma or major surgery are at the highest risk for ARC, as well as those with sepsis, burns, or hematologic malignancies. An 8- to 24-hour measured urinary CrCl is necessary to identify these patients (Ref).

IV:

If usual recommended dose is 1 to 2 g every 6 hours: 2 g every 4 hours (Ref).

If usual recommended dose is 2 g every 4 hours: Some patients may not meet pharmacodynamic targets with 2 g every 4 hours dosing; monitor closely, consider utilizing a prolonged or continuous infusion, and if necessary, switching to an alternative agent (Ref).

CRRT: Drug clearance is dependent on the effluent flow rate, filter type, and method of renal replacement. Recommendations are based on high-flux dialyzers and effluent flow rates of 20 to 25 mL/kg/hour (or ~1,500 to 3,000 mL/hour) unless otherwise noted. Appropriate dosing requires consideration of adequate drug concentrations (eg, site of infection) and consideration of initial loading doses. Close monitoring of response and adverse reactions (eg, neurotoxicity) due to drug accumulation is important.

CVVH/CVVHD/CVVHDF: IV:

If usual recommended dose is 1 to 2 g every 6 hours: 2 g every 8 to 12 hours (Ref).

If usual recommended dose is 2 g every 4 hours: 2 g every 6 to 8 hours (Ref).

PIRRT (eg, sustained, low-efficiency diafiltration): Drug clearance is dependent on the effluent flow rate, filter type, and method of renal replacement. Appropriate dosing requires consideration of adequate drug concentrations (eg, site of infection) and consideration of initial loading doses. Close monitoring of response and adverse reactions (eg, neurotoxicity) due to drug accumulation is important.

Note: Where possible, schedule one of the doses for after the PIRRT session (Ref).

IV:

If usual recommended dose is 1 to 2 g every 6 hours: 2 g every 8 to 12 hours (Ref).

If usual recommended dose is 2 g every 4 hours: 2 g every 8 hours (Ref).

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

(For additional information see "Ampicillin: Pediatric drug information")

General dosing (Ref):

Infants, Children, and Adolescents:

Oral: 50 to 100 mg/kg/day divided every 6 hours; maximum daily dose: 2,000 mg/day.

IM, IV: 50 to 200 mg/kg/day divided every 6 hours; maximum daily dose: 8 g/day; higher doses (300 to 400 mg/kg/day divided every 4 to 6 hours; maximum daily dose: 12 g/day) are recommended for some infections.

Anthrax, treatment

Anthrax, treatment: Limited data available:

Note: Consult public health officials for event-specific recommendations; after completion of therapy, initiate antimicrobial prophylaxis to complete an antimicrobial course of 60 days from onset of illness (Ref).

Systemic, excluding meningitis: Infants, Children, and Adolescents: IV: 200 mg/kg/day divided every 6 hours; maximum daily dose: 12 g/day. Use as part of an appropriate combination regimen; may switch to oral follow-up therapy when signs and symptoms of active infection are resolved; complete 2 weeks of therapy or until clinical improvement, whichever is longer (Ref).

Meningitis or disseminated infection in which meningitis cannot be ruled out: Infants, Children, and Adolescents: IV: 400 mg/kg/day divided every 6 hours; maximum daily dose: 12 g/day. Use as part of an appropriate combination regimen for 2 to 3 weeks of therapy or until patient is clinically stable, whichever is longer (Ref).

Endocarditis; treatment

Endocarditis; treatment:

Children and Adolescents: IV: 200 to 300 mg/kg/day divided every 4 to 6 hours; maximum daily dose: 12 g/day; use in combination with other antibiotics for at least 4 weeks; some organisms may require longer duration (Ref).

Endocarditis; prophylaxis before invasive dental procedures

Endocarditis; prophylaxis before invasive dental procedures (alternative agent): Limited data available:

Note: Alternative agent for use in patients unable to take oral medication. Recommended only in patients who are at highest risk for infective endocarditis (IE) or adverse outcomes (eg, history of IE, cardiac valve repair using prosthetic valves or material, unrepaired cyanotic congenital heart disease [CHD], left ventricular assist device or implantable heart, repaired CHD with prosthetic material or device during first 6 months after procedure, pulmonary artery valve or conduit placement [eg, Melody valve, Contegra conduit], repaired CHD with residual defects at the site or adjacent to site of prosthetic patch or device, heart transplant recipients with cardiac valvulopathy) (Ref).

Infants, Children, and Adolescents: IV, IM: 50 mg/kg as a single dose administered 30 to 60 minutes prior to dental procedure; maximum dose: 2,000 mg/dose (Ref).

Intra-abdominal infection, complicated

Intra-abdominal infection, complicated: Infants, Children, and Adolescents: IV: 200 mg/kg/day divided every 6 hours; maximum single dose: 2,000 mg; maximize doses if undrained abdominal abscesses (Ref).

Meningitis

Meningitis (including health care-associated meningitis and ventriculitis): Infants, Children, and Adolescents: IV: 300 to 400 mg/kg/day divided every 4 to 6 hours; maximum daily dose: 12 g/day (Ref).

Peritonitis

Peritonitis (CAPD): Limited data available: Infants, Children, and Adolescents: Intraperitoneal: 125 mg per liter of dialysate for 2 weeks (Ref).

Pneumonia, community-acquired

Pneumonia, community-acquired (CAP) (Ref): Infants >3 months, Children, and Adolescents: Note: May consider addition of vancomycin or clindamycin to empiric therapy if community-acquired MRSA suspected. In children ≥5 years, a macrolide antibiotic should be added if atypical pneumonia cannot be ruled out.

Empiric treatment or S. pneumoniae (MICs for penicillin ≤2 mcg/mL) or H. influenzae (beta-lactamase negative) in fully immunized patients: IV: 150 to 200 mg/kg/day divided every 6 hours.

Group A Streptococcus: IV: 200 mg/kg/day divided every 6 hours.

S. pneumoniae (MICs for penicillin ≥4 mcg/mL): IV: 300 to 400 mg/kg/day divided every 6 hours.

Surgical prophylaxis

Surgical prophylaxis: Infants, Children, and Adolescents: IV: 50 mg/kg within 60 minutes prior to surgical incision; may repeat in 2 hours if lengthy procedure or excessive blood loss; maximum dose: 2,000 mg/dose (Ref).

Dosing: Kidney Impairment: Pediatric

Infants, Children, and Adolescents: There are no dosage adjustments provided in the manufacturer's labeling; however, the following adjustments have been recommended (Ref). Note: Renally adjusted dose recommendations are based on IM, IV doses of 100 to 200 mg/kg/day divided every 6 hours: IM, IV:

GFR 30 to 50 mL/minute/1.73 m2: 35 to 50 mg/kg/dose every 6 hours

GFR 10 to 29 mL/minute/1.73 m2: 35 to 50 mg/kg/dose every 8 to 12 hours

GFR <10 mL/minute/1.73 m2: 35 to 50 mg/kg/dose every 12 hours

Intermittent hemodialysis: 35 to 50 mg/kg/dose every 12 hours

Peritoneal dialysis (PD): 35 to 50 mg/kg/dose every 12 hours

Continuous renal replacement therapy (CRRT): 35 to 50 mg/kg/dose every 6 hours

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Frequency not defined.

Central nervous system: Brain disease (penicillin-induced), glossalgia, seizure, sore mouth

Dermatologic: Erythema multiforme, exfoliative dermatitis, skin rash, urticaria

Note: Appearance of a rash should be carefully evaluated to differentiate (if possible) nonallergic ampicillin rash from hypersensitivity reaction. Incidence is higher in patients with viral infection, Salmonella infection, lymphocytic leukemia, or patients that have hyperuricemia.

Gastrointestinal: Diarrhea, enterocolitis, glossitis, melanoglossia, nausea, oral candidiasis, pseudomembranous colitis, stomatitis, vomiting

Hematologic & oncologic: Agranulocytosis, anemia, eosinophilia, hemolytic anemia, immune thrombocytopenia, leukopenia

Hepatic: Increased serum AST

Hypersensitivity: Anaphylaxis

Immunologic: Serum sickness-like reaction

Renal: Interstitial nephritis (rare)

Respiratory: Stridor

Miscellaneous: Fever

<1%, postmarketing, and/or case reports: Dysgeusia (Syed 2016)

Contraindications

Hypersensitivity (eg, anaphylaxis) to ampicillin, any component of the formulation, or other penicillins; infections caused by penicillinase-producing organisms

Warnings/Precautions

Concerns related to adverse effects:

• Hypersensitivity/anaphylactoid reactions: Serious and occasionally severe or fatal hypersensitivity (anaphylactoid) reactions have been reported in patients on penicillin therapy, especially with a history of beta-lactam hypersensitivity or a history of sensitivity to multiple allergens. Serious anaphylactoid reactions require emergency treatment and airway management. Appropriate treatments must be readily available.

• Rash: Appearance of a rash should be carefully evaluated to differentiate a nonallergic ampicillin rash from a hypersensitivity reaction; rash occurs in 5% to 10% of children and is a generalized dull red, maculopapular rash, generally appearing 3 to 14 days after the start of therapy. It normally begins on the trunk and spreads over most of the body. It may be most intense at pressure areas, elbows, and knees.

• Superinfection: Prolonged use may result in fungal or bacterial superinfection, including Clostridioides difficile–associated diarrhea (CDAD) and pseudomembranous colitis; CDAD has been observed >2 months postantibiotic treatment.

Disease-related concerns:

• Infectious mononucleosis: A high percentage of patients with infectious mononucleosis have developed rash during therapy; ampicillin-class antibiotics not recommended in these patients. Rash (generalized maculopapular and pruritic) usually appears 7 to 10 days after initiation and usually resolves within a week of discontinuation. It is not known whether these patients are truly allergic to ampicillin

• Renal impairment: Use with caution in patients with renal impairment; dosage adjustment recommended.

Warnings: Additional Pediatric Considerations

Ampicillin has been shown to prolong the bleeding time in neonates in 2 prospective studies. The first study found a prolonged bleeding time by an average of 60 seconds longer than baseline in neonates (n=15; GA: 33 to 41 weeks; weight: 1,760 to 3,835 g) after receiving the third and fourth doses of ampicillin (50 to 100 mg/kg/dose every 12 hours) (Sheffield 2010). The second study evaluated the effect on bleeding time in very low birth weight patients (n=20; GA: 23 to 33 weeks; weight: 400 to 1,410 g); results showed that patients receiving ampicillin for ≥10 days had a prolonged bleeding time compared to baseline; on average bleeding time was 2 minutes longer (p=0.001) (Sheffield 2011). The clinical significance of ampicillin's effect on bleeding time is unknown, but probably depends on the patient's clinical status and risk of hemorrhage.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Capsule, Oral:

Generic: 500 mg

Solution Reconstituted, Injection, as sodium [strength expressed as base, preservative free]:

Generic: 125 mg (1 ea); 250 mg (1 ea); 500 mg (1 ea); 1 g (1 ea); 2 g (1 ea)

Solution Reconstituted, Intravenous, as sodium [strength expressed as base, preservative free]:

Generic: 1 g (1 ea); 2 g (1 ea); 10 g (1 ea)

Generic Equivalent Available: US

Yes

Pricing: US

Capsules (Ampicillin Oral)

500 mg (per each): $0.65

Solution (reconstituted) (Ampicillin Sodium Injection)

1 g (per each): $1.93 - $8.64

2 g (per each): $2.80 - $16.75

125 mg (per each): $5.22

250 mg (per each): $2.34 - $4.19

500 mg (per each): $2.70 - $4.41

Solution (reconstituted) (Ampicillin Sodium Intravenous)

1 g (per each): $16.37 - $17.91

2 g (per each): $31.76 - $34.75

10 g (per each): $76.80 - $107.77

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Capsule, Oral:

Generic: 250 mg, 500 mg

Solution Reconstituted, Injection, as sodium [strength expressed as base]:

Generic: 250 mg (1 ea); 500 mg (1 ea); 1 g (1 ea); 2 g (1 ea)

Administration: Adult

Administer around-the-clock to promote less variation in peak and trough serum levels.

Oral: Administer on an empty stomach with a full glass (8 oz) of water (ie, 30 minutes prior to or 2 hours after meals) to increase total absorption.

IM.: Inject deep IM into a large muscle mass

IV: Direct IV bolus: Administer over 3 to 5 minutes (125 to 500 mg) or over 10 to 15 minutes (1 to 2 g). More rapid infusion may cause seizures.

Infusion: Rapid infusion may cause seizures. Adjust rate of infusion so that the total dose is administered before admixture stability expires.

Administration: Pediatric

Oral: Administer on an empty stomach (ie, 30 minutes prior to or 2 hours after meals) to increase total absorption; shake suspension well before using.

Parenteral:

IM: Inject deep IM into a large muscle mass.

IV:

IV push: Doses ≤500 mg should be administered over 3 to 5 minutes; doses >500 mg should be administered over 10 to 15 minutes; rapid administration has been associated with seizures.

Intermittent IV infusion: Avoid infusing concomitantly with aminoglycosides if feasible; consult drug interactions database for more information.

Neonates: Infuse over ≥20 minutes; shorter infusions may result in peak concentrations above the neurotoxicity exposure threshold (Ref).

Infants, Children, and Adolescents: Infuse over 10 to 15 minutes.

Use: Labeled Indications

Oral:

GI tract infections: Treatment of GI tract infections caused by Shigella, Salmonella typhosa and other Salmonella, Escherichia coli, Proteus mirabilis, and enterococci. Note: Ampicillin is not recommended as a first-line agent for shigellosis, salmonellosis (nontyphoid), or Salmonella enterica species (typhoid fever) due to development of resistance (CDC 2014).

GU tract infections: Treatment of GU tract infections caused by E. coli, P. mirabilis, enterococci, Shigella, S. typhosa, and other Salmonella.

Respiratory tract infections: Treatment of respiratory tract infections caused by nonpenicillinase-producing Haemophilus influenzae and staphylococci, and streptococci, including Streptococcus pneumoniae.

Injection:

Bloodstream infection: Treatment of bloodstream infection caused by susceptible gram-positive organisms, including Streptococcus species, penicillin G-susceptible staphylococci, and enterococci; gram-negative bloodstream infection caused by E. coli, P. mirabilis, and Salmonella species.

Endocarditis, treatment: Treatment of endocarditis caused by susceptible gram-positive organisms, including Streptococcus species, penicillin G-susceptible staphylococci, and enterococci.

GI infections: Treatment of GI infections caused by S. typhi (typhoid fever), other Salmonella species, and Shigella species (dysentery). Note: Ampicillin is not recommended as a first-line agent for shigellosis, salmonellosis (nontyphoid), or S. enterica species (typhoid fever) due to development of resistance (CDC 2014).

Meningitis, bacterial: Treatment of bacterial meningitis caused by E. coli, group B streptococci, and other gram-negative bacteria (Neisseria meningitidis).

Respiratory tract infections: Treatment of respiratory tract infections caused by S. pneumoniae, Staphylococcus aureus (penicillinase and nonpenicillinase producing), H. influenzae, and group A beta-hemolytic streptococci.

Urinary tract infections: Treatment of urinary tract infections caused by E. coli and P. mirabilis.

Use: Off-Label: Adult

Endocarditis, prophylaxis; Intra-abdominal infection, health care-associated; Intra-amniotic infection (chorioamnionitis); Osteomyelitis and/or discitis, treatment; Peritonitis, treatment (peritoneal dialysis patients); Postpartum endometritis; Prosthetic joint infection; Streptococcus (group B), maternal prophylaxis for prevention of neonatal disease; Surgical prophylaxis; Tubo-ovarian abscess

Medication Safety Issues
Sound-alike/look-alike issues:

Ampicillin may be confused with aminophylline

Metabolism/Transport Effects

Substrate of OAT1/3

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.

Acemetacin: May increase the serum concentration of Penicillins. Risk C: Monitor therapy

Allopurinol: May enhance the potential for allergic or hypersensitivity reactions to Ampicillin. Risk C: Monitor therapy

Aminoglycosides: Penicillins may decrease the serum concentration of Aminoglycosides. Primarily associated with extended spectrum penicillins, and patients with renal dysfunction. Risk C: Monitor therapy

Atenolol: Ampicillin may decrease the bioavailability of Atenolol. Risk C: Monitor therapy

Bacillus clausii: Antibiotics may diminish the therapeutic effect of Bacillus clausii. Management: Bacillus clausii should be taken in between antibiotic doses during concomitant therapy. Risk D: Consider therapy modification

BCG (Intravesical): Antibiotics may diminish the therapeutic effect of BCG (Intravesical). Risk X: Avoid combination

BCG Vaccine (Immunization): Antibiotics may diminish the therapeutic effect of BCG Vaccine (Immunization). Risk C: Monitor therapy

Chloroquine: May decrease the serum concentration of Ampicillin. Management: Separate the administration of ampicillin and chloroquine by at least 2 hours to minimize any potential negative impact of chloroquine on ampicillin bioavailability. Risk D: Consider therapy modification

Cholera Vaccine: Antibiotics may diminish the therapeutic effect of Cholera Vaccine. Management: Avoid cholera vaccine in patients receiving systemic antibiotics, and within 14 days following the use of oral or parenteral antibiotics. Risk X: Avoid combination

Dichlorphenamide: Penicillins may enhance the hypokalemic effect of Dichlorphenamide. Risk C: Monitor therapy

Fecal Microbiota (Live) (Oral): May diminish the therapeutic effect of Antibiotics. Risk X: Avoid combination

Fecal Microbiota (Live) (Rectal): Antibiotics may diminish the therapeutic effect of Fecal Microbiota (Live) (Rectal). Risk X: Avoid combination

Immune Checkpoint Inhibitors (Anti-PD-1, -PD-L1, and -CTLA4 Therapies): Antibiotics may diminish the therapeutic effect of Immune Checkpoint Inhibitors (Anti-PD-1, -PD-L1, and -CTLA4 Therapies). Risk C: Monitor therapy

Khat: May decrease the serum concentration of Ampicillin. Management: Consider administering ampicillin 2 hours after khat chewing to avoid reductions in ampicillin bioavailability. Risk D: Consider therapy modification

Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol. Risk C: Monitor therapy

Lanthanum: May decrease the serum concentration of Ampicillin. Management: Administer oral ampicillin at least two hours before or after lanthanum. Risk D: Consider therapy modification

Methotrexate: Penicillins may increase the serum concentration of Methotrexate. Risk C: Monitor therapy

Mycophenolate: Penicillins may decrease serum concentrations of the active metabolite(s) of Mycophenolate. This effect appears to be the result of impaired enterohepatic recirculation. Risk C: Monitor therapy

Probenecid: May increase the serum concentration of Penicillins. Risk C: Monitor therapy

Sodium Benzoate: Penicillins may diminish the therapeutic effect of Sodium Benzoate. Risk C: Monitor therapy

Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Risk D: Consider therapy modification

Tegoprazan: May decrease the serum concentration of Ampicillin. Risk C: Monitor therapy

Tetracyclines: May diminish the therapeutic effect of Penicillins. Risk C: Monitor therapy

Typhoid Vaccine: Antibiotics may diminish the therapeutic effect of Typhoid Vaccine. Only the live attenuated Ty21a strain is affected. Management: Avoid use of live attenuated typhoid vaccine (Ty21a) in patients being treated with systemic antibacterial agents. Postpone vaccination until 3 days after cessation of antibiotics and avoid starting antibiotics within 3 days of last vaccine dose. Risk D: Consider therapy modification

Vitamin K Antagonists (eg, warfarin): Penicillins may enhance the anticoagulant effect of Vitamin K Antagonists. Risk C: Monitor therapy

Food Interactions

Food decreases ampicillin absorption rate; may decrease ampicillin serum concentration. Management: Take at equal intervals around-the-clock, preferably on an empty stomach (30 minutes before or 2 hours after meals). Maintain adequate hydration, unless instructed to restrict fluid intake.

Pregnancy Considerations

Ampicillin crosses the placenta.

Detectable concentrations of ampicillin are present in the cord serum and amniotic fluid following maternal IM, IV, and oral administration (Nau 1987). In a study of women treated with IV ampicillin for group B streptococcal (GBS) prophylaxis, peak concentrations in the umbilical cord were observed 30 minutes after the maternal dose and effective neonatal concentrations continued for ≥4 hours when a loading dose was given (Berardi 2018).

Due to pregnancy-induced physiologic changes, the pharmacokinetics of ampicillin may be altered; dose adjustments may be needed. Although oral absorption is not altered during pregnancy, oral ampicillin is poorly absorbed during labor (Kubacka 1983; Nau 1987).

As a class, penicillin antibiotics are widely used in pregnant patients. Based on available data, penicillin antibiotics are generally considered compatible for use during pregnancy (Ailes 2016; Bookstaver 2015; Crider 2009; Czeizel 2001; Damkier 2019; Heinonen 1977; Lamont 2014; Muanda 2017a; Muanda 2017b).

Untreated intraamniotic infection (chorioamnionitis) may lead to adverse pregnancy outcomes, including pneumonia, meningitis, and sepsis, in the newborn. Maternal complications may include postpartum uterine atony with hemorrhage, endometritis, peritonitis, sepsis, or adult respiratory distress syndrome. Ampicillin is part of the recommended regimen for the treatment of intraamniotic infection (ACOG 2017).

Untreated asymptomatic GBS disease can result in maternal urinary tract infection, intraamniotic infection, endometritis, preterm labor, and/or stillbirth. Vertical transmission from the mother can cause sepsis, pneumonia, or meningitis in the newborn. IV ampicillin is recommended as an alternative antibiotic for intrapartum prophylaxis to prevent neonatal GBS early-onset disease (ACOG 2020b).

Ampicillin is recommended for use in pregnant patients for the management of preterm prelabor rupture of membranes (PROM); treatment with antibiotics is used to prolong pregnancy and decrease maternal and newborn infections (ACOG 2020a). Ampicillin may also be used in certain situations prior to vaginal delivery in patients at high risk for endocarditis (ACOG 2018).

Ampicillin may be a preferred agent for the treatment of asymptomatic bacteriuria in pregnancy (IDSA [Nicolle 2019]).

Maternal Listeria monocytogenes infection varies from asymptomatic disease requiring no therapy to a febrile illness with or without additional symptoms, resulting in severe pregnancy outcomes, including fetal loss, preterm labor, neonatal sepsis, meningitis, and maternal death. Maternal treatment with IV ampicillin is recommended when fever is present, exposure is suspected, and no other cause of illness is known (ACOG 2014).

Breastfeeding Considerations

Ampicillin is present in breast milk.

Concentrations of penicillin class antibiotics are limited in breast milk (Nau 1987). Following an oral dose of ampicillin 500 mg to 2 or 3 women 5 to 7 days postpartum, breast milk concentrations ranged from trace amounts 1 hour after the dose to 0.16 mcg/mL 6 hours after the dose. In contrast, the highest maternal serum concentration (7 mcg/mL) was found 1 hour after the dose, decreasing to ≤0.4 mcg/mL 6 hours after the dose (Matsuda 1984). A second study administered oral ampicillin 500 mg 4 times a day to 10 breastfeeding women following delivery. Maternal serum and breast milk were sampled over 6 hours on days 3 and 4 of therapy. Ampicillin concentrations were 0.015 to 1.67 mcg/mL (breast milk) and 0.56 to 5.42 mcg/mL (maternal serum) (Campbell 1991).

A prospective cohort study evaluated the outcomes of breastfed infants whose mothers were taking various medications. Among 5 mother-infant pairs with reported ampicillin exposure (dose, duration, relationship to breastfeeding not provided), diarrhea was reported in 1 infant (Ito 1993). A group of 21 breastfeeding mothers taking ampicillin were given a specially designed record sheet to monitor possible ampicillin-induced side effects in their infants for 15 days postdelivery. These infants were compared to a control group of 45 breastfed infants whose mothers were not taking antibiotics. There were no significant differences between the groups (Campbell 1991). In general, antibiotics that are present in breast milk may cause nondose-related modification of bowel flora. Monitor infants for GI disturbances, such as thrush or diarrhea (WHO 2002).

Although the manufacturer recommends that caution be exercised when administering ampicillin to breastfeeding patients, ampicillin is considered compatible with breastfeeding when used in usual recommended doses (WHO 2002).

Dietary Considerations

Take on an empty stomach 30 minutes before or 2 hours after meals. Some products may contain sodium.

Monitoring Parameters

With prolonged therapy, monitor renal, hepatic, and hematologic function periodically; observe signs and symptoms of anaphylaxis during first dose

Mechanism of Action

Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs) which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

Pharmacokinetics (Adult Data Unless Noted)

Absorption: Oral: 50%

Distribution: Into bile; penetration into CSF occurs with inflamed meninges only

Protein binding: Neonates: 10%; Adults: 15% to 18%

Half-life elimination:

Neonates:

PNA 2 to 7 days: 4 hours

PNA 8 to 14 days: 2.8 hours

PNA 15 to 30 days: 1.7 hours

Children and Adults: 1 to 1.8 hours (Bergan 1978)

Anuric patients: 8 to 20 hours

Time to peak serum concentration: Oral: Within 1 to 2 hours

Excretion: Urine (∼90%, unchanged within 24 hours); feces

Pharmacokinetics: Additional Considerations (Adult Data Unless Noted)

Anti-infective considerations:

Parameters associated with efficacy:

Time-dependent; associated with time free drug concentration (fT) > minimum inhibitory concentration (MIC), goal: ≥40% fT>MIC (bactericidal) (Craig 1998; Lacy 1999); some experts favor 100% fT>MIC in critically ill patients, including neonates (Le 2022; Roberts 2014).

Expected drug exposure in normal renal function:

Adults, Cmax (peak):

250 mg dose (oral capsule): ~2.3 mg/L.

500 mg dose (oral capsule): ~3 mg/L.

500 mg every 6 hours (IV), steady state: 10.2 ± 0.8 mg/L (Lacy 1999).

1 g every 6 hours (IV), steady state: 40.9 ± 6.6 mg/L (Lacy 1999).

Postantibiotic effect: Generally <1 hour, varies by organism (Craig 1993; Craig 1998).

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Ampicillin | Ampicillin Pierrel | Ampicina | Ampicipen | Ampicyn | Ampidar | Ampilag | Amplital | Binotal | Epicocillin | Extrapen | Julphapen | Lifeampil | Norcipen | Overcillina | Pamecil | Penbritin | Pentrexyl K | Rivocillin | Roscillin | Servicillin;
  • (AR) Argentina: Alpovex | Ampi bis | Ampicilina | Ampicilina duncan | Ampicilina fecofar | Ampicilina ingram | Ampicilina lemax | Ampicilina pharmavial | Ampicilina richet | Ampicler | Ampigen simple | Ampigrand | Ampitenk | Atecilina | Cronopen | Decilina | Fada Ampicilina | Histopen | Hostes | Trifacilina;
  • (AT) Austria: Standacillin;
  • (AU) Australia: Agpen | Alphacin | Ampicyn | Austrapen | Ibimicyn | Penbritin;
  • (BD) Bangladesh: Acmecilin | Admox | Aldapen | Almoxil | Amblosin | Ampen | Ampexin | Ampicillin | Ampicin | Ampimet | Ampirex | Ampisina | Ampritin | Avlocillin | Bipicillin | Centacillin | Champicin | Decilin | Ficillin | Kamocillin | Navacillin | Pen A | Penacillin | Simpicillin | Skycillin;
  • (BE) Belgium: Penbritin | Pentrexyl;
  • (BF) Burkina Faso: Ampicilline | Ampicilline tm | Ampicilline ubigen | Philco ampicillin;
  • (BG) Bulgaria: Ampicillin | Standacillin | Upsampi;
  • (BR) Brazil: Ambezetal | Ampi | Ampiciflan | Ampicil | Ampicilab | Ampicilase | Ampicilib | Ampicilil | Ampicilina | Ampicilina sodica | Ampicilon | Ampicinal | Ampicler | Ampifar | Ampifar Balsamico | Ampiger | Ampigran | Ampilozin | Ampitrat | Ampival | Ampixin | Ampizan | Amplacilina | Amplacin | Amplatil | Amplibac | Amplitor | Amplocilin | Amplotal | Bacterinil | Benzotal | Binotal | Bipencil | Cilinon | Cilipen | Durapen | Emicilin | Expectocilin | Furp ampicilina | Genocilina | Neo ampicilin | Optacilin | Praticilin | Sifcilina | Teuplafec | Uni ampicilin | Uniao ampicilina;
  • (CH) Switzerland: Cimexillin | Penbristol | Penbritin | Servicillin;
  • (CI) Côte d'Ivoire: Ampicillin | Ampicilline | Ampicilline creat | Ampicilline ubigen | Apo-ampi | Standacillin;
  • (CL) Chile: Ampicilina;
  • (CN) China: A bi xian | Ampicillin | Ampilin | An bi xian | An bi xian-sanye | An sa | Bi xian su | En pu luo | Servicillin | Yi xi de;
  • (CO) Colombia: Ambigel | Ambiopen | Amdelt | Amfipen | Ampicilina | Ampicilina mk | Ampicilina MK | Ampicilina sodica | Ampicyl | Ampyfec | Binotal | Decapen | Deucilina | Eucilina | Impo cilina | Meprizina | Omnipen | Penamplia | Pentrexyl | Picylin | Principen | Servicilina;
  • (CZ) Czech Republic: Ampicillin | Apo ampi | Penstabil | Pentrexyl | Semicillin | Servicillin;
  • (DE) Germany: Ampicillin | Ampicillin ratiopharm | Ampicillin STADA | Binotal | Duraampicillin | Penbrock;
  • (DO) Dominican Republic: Alfacin | Alpra | Ampibex | Ampicilex | Ampicilina | Ampicilina Calox | Ampicilina mk | AmpiDek | Ampidelta | Ampifarma | Ampimer | Ampina | Ampisan | Ampitrex | Arcocillin | Binotal | Flamicina | Lufracilina | Pen am | Pencil | Pentrexyl | Plumericin | Ragocilina | Servicillin | Standacillin;
  • (EC) Ecuador: Ampecu | Ampi-Infant | Ampibex | Ampicher | Ampicilina | Ampicilina g.a. | Ampicilina Genfar | Ampicilina genfar | Ampicilina MK | Ampicilina mk | Ampigeme | Ampil | Ampilan | Ampistar | Binotal | Deripen | Exactum | Julphapen | Libracilina | Novencil | Pentrexyl | Servicillin;
  • (EE) Estonia: Ampicillin | Ampicillinum | Pamecil | Pentrexyl | Standacillinum;
  • (EG) Egypt: Ampicid | Ampicillin | Ampicilline | Ampicinal | Epicocillin;
  • (ES) Spain: Ampicilina llorente | Antibiopen | Britapen | Electopen | Gobemicina | Maxicilina duplex | Retarpen | Ultrapenil;
  • (ET) Ethiopia: Ampicillin | Ascillin | Epicocillin;
  • (FI) Finland: A-pen | Adipenin | Ampicillin mylan | Ampicillin Strides | Doktacillin | Dumopen | Pentrexyl;
  • (FR) France: Ampicilline Dakota | Ampicilline gnr | Ampicilline panpharma | Negmapen | Rosampline;
  • (GB) United Kingdom: Ampicillin | Ampicillin arrow | Ampicillin berk | Ampicillin cox | Ampicillin dc | Ampicillin kent | Ampicillin sandoz | Ampilar | Ampitrin | Britcin | Flu-amp | Kap amp | Penbritin | Rimacillin | Vidopen;
  • (GR) Greece: Ampicillin | Isticilline | Pentrexyl | Xanline;
  • (HK) Hong Kong: Ampiciller | Ampicillin | Ampicin | Ampik | Ampisol | Ampisul | Amprexyl | Ancillina | Besteillin | Dhacillin | Euro-ampicillin | Neo britin | Nice ampi | Pamecil | Penbritin | Pentrexyl | Polecillin | Quali-Amp | Reichlin | Servicillin | Syntocil | U cillin | Unicillin;
  • (HR) Croatia: Ampicilin Sandoz;
  • (HU) Hungary: Ampicillin | Huma-ampicillin | Penbritin | Penstabil | Pentrexyl | Standacillin;
  • (ID) Indonesia: Aktoralin | Ambiopi | Amcillin | Amfipen | Ampex | Ampi | Ampicen | Ampicil | Ampicillin | Ampicilline | Ampipen | Arcocillin | Bannsipen | Binotal | Biopenam | Biopensyn | Bremcillin | Brodacillin | Camicilline | Cetacillin | Corsacillin | Dancillin | Decapen | Dexypen | Erphacillin | Etabiotic | Gunabiotik | Hopacillin | Ikacillin | Indopen | Itrapen | Kalpicilin | Kemocil | Lactapen | Megapen | Mepropen | Metacillin | Mycill | Omnipen | Opicillin | Oracipen | Parpicillin | Penbiotic | Penbritin | Pencil | Phapin | Pharocillin | Polypen | Primacillin | Primapen | Rampicillin | Ronexol | Sambritin | Sanpicillin | Scancipen | Standacillin | Ultrapen | Viccillin | Xepacillin | Yekacillin;
  • (IE) Ireland: Ampicillin | Clonamp | Novapen | Penbritin | Rimacillin;
  • (IL) Israel: Penibrin;
  • (IN) India: Amcin | Amp | Ampdec | Ampicillin | Ampik | Ampikem | Ampilin | Ampillin | Ampilon | Ampise | Ampisyn | Ampurin | Antilin | Antillin | Aristocillin | Bacipen | Biocilin | Biocillin | Blucillin | Broacil | Broadicilin | Campicilin | Cincillin | Conampi | Dynacil | Elcillin | Gercillin | Impen | J P Cillin | J.p.cillin | Labcillin | Lupillin | Monacilin | Natcocillin | Nepocil | Pharampicillin | Piracillin | Polypen | Pressilin | Raympillin | Roscillin | Saincillin | Sterpen | Suziclox | Synthocilin | Uniamp | Versatillin | Zcil;
  • (IT) Italy: Ampicillina | Ampicillina biopharma | Ampilux | Ampiplus Simplex | Amplital | Amplizer | Ibimicyn;
  • (JO) Jordan: Amibel | Ampicent | Ampidar | Ampipharm | Pamecil | Penbritin | Pentrexil | Standacillin | Ultracillin;
  • (JP) Japan: Adobacillin | Amipenix | Ampicillin amel | Ampicillin fujimoto | Ampicillin merck hoei | Ampicillin nichiiko | Ampicillin otsuka | Ampicillin pfizer | Ampicillin sanko | Ampicillin sawai | Ampicillin showa | Ampicillin taisho | Ampicillin tatumi | Ampicillin teikoku | Ampicillin towa | Ampicillin tsuruhara | Bonapicilin | Cilleral | Domicillin | Extopen | Iwacillin | Marisilan | Nccilin | Ohtecin | Penbritin | Penimic | Pentrex | Pharcillin | Saicilin | Sod.ampicillin fujo | Sod.ampicillin taisho | Solcillin | Synpenin | Tokiocillin | Totacillin | Viccillin;
  • (KE) Kenya: Ampecin | Ampicen | Ampicillin | Ampik | Ampilin | Ascillin | Biopen | Curecillin | Gestacillin | Lacillin | Pcillin | Uniamp | Z cil;
  • (KR) Korea, Republic of: Amcillin | Ampi | Ampicillin | Campi | Mpisen | Penbrex;
  • (KW) Kuwait: Penbritin;
  • (LB) Lebanon: Ampicillin | Ampicilline | Penbritin | Pentrexyl;
  • (LT) Lithuania: Ampicilina | Ampicillin | Apo ampi | Campicillin | Pan ampicillin | Penbritin | Penstabil | Pentrexyl | Standacillin;
  • (LU) Luxembourg: Fortapen | Penbritin | Pentrexyl;
  • (LV) Latvia: Ampicillin | Ampicillin ratiopharm | Ampicillin trihydras | Apo ampi | Campicillin | Pamecil | Pan ampicillin | Penbritin | Penibrin | Penstabil | Pentrexyl | Standacillin;
  • (MA) Morocco: Amblosin | Ampicilline llorente | Apo-ampi | Opticilline | Standacillin | Totapen;
  • (MX) Mexico: Acilmed | Ambidrin | Ampi quim | Ampi quim pediatrico | Ampi tecno | Ampicidar | Ampicilina | Ampicilina collins | Ampicilina gi | Ampicilina gi diba | Ampicilina gi ivax | Ampicilina gi pisa | Ampicilina gi serr | Ampicilina hormona | Ampicilina keyer | Ampimex | Amsapen | Anglopen | Aristocilin | Binotal | Bremicina | Brupen | Coltapen | Deamcilina | Dibacilina | Expicin | Flamicina | Gramipen F | Iqfacilina | Lampicin | Lixilina | Marovilina | Meprizina | Mexapin | Mibiot | Mobiot | Omnipen | Penbritin | Pentiver | Pentrexyl | Promecilina | Raphilina tri | Sinaplin;
  • (MY) Malaysia: Amcin | Amillin | Ampicap | Ampicap-T | Ampicilla | Ampicillin | Ampicyn | Ampigran | Ampilin | Ampillin | Ampisol | Biocil | Dhacillin | Kampibiotic | Pamecil | Penbritin | Pricillin | Setcillin | Standacillin | Synamin;
  • (NG) Nigeria: Aframpi | Cikacillin | Climpicillin | Evans ampicillin | Mirapicin | Nemecillin | Vitacillin;
  • (NL) Netherlands: Pentrexyl;
  • (NO) Norway: Ampicillin | Ampicillin mylan | Ampicillin pcd | Ampicillin ratiopharm | Ampicillin stada | Ampicillin Strides | Doktacillin | Pentrexyl;
  • (PE) Peru: Ab ambromox | Ab broncol nf 1200 | Ab broncol nf 300 | Ab broncol nf 600 | Ampicilina | Ampicilina lusa | Ampicilina markos | Ampicilina trifarma | Ampicilina uqp | Ampiflex | Ampisint | Amplibin | Binotal | Dentacilina | Hiperbiotico | Ipcacillin | Julphapen | Magnapen | Neo-terbocilin | Omnipen | Penbritin | Roscillin | Sintelin;
  • (PH) Philippines: Aldribid | Altozin | Amdricil | Ampedia | Ampi 1 | Ampicillin | Ampicin | Ampico | Ampin | Ampinex | Ampisan | Ampitrex | Ampivex | Amplivacil | Angypex | Apamacin | Bactimed | Bactropen | Biogenerics ampicillin | Biostacil | Boie ampicillin | Bridopen | Clovillin | Dancin | Dincil | Dli-ampicillin | Eurocin | Eurotrexil | Excillin | Gramcil | Knolicin | Leoplex | Liferzin | Mapciril | May ampicillin | Medic aid ampicillin | Meljimar | Obocil | Panacta | Penbritin | Pensyn | Pentrexyl | Polypen | Rotocin | Shinapen | Sodampen | Sumpilin | Vatacil | Vonpicin | Yss ampicillin sodium | Zerrucillin;
  • (PK) Pakistan: Amicil | Ampicap | Ampicil | Ampicillin | Ampillin | Ampilo | Ampimaz | Ampin | Ampistal | Ampiwil | Amplipen | Amplox | Anglocillin | Empecil | Epocillin | Epoclox | Fedropen | Hizopen | M-cil | Maxibiotic | Medicillin | Novocillin | Nuvapen | Omnipen | Penbritin | Pencipen | Pexopen | Polycillin | Standacillin | Ultrapen | Zampicillin | Zyncillin;
  • (PL) Poland: Ampicillin | Penstabil;
  • (PR) Puerto Rico: Ampicillin | Omnipen | Polycillin | Principen | Totacillin-n;
  • (PT) Portugal: Ampicilina | Amplifar | Hiperbiotico | Hiperbiotico retard;
  • (PY) Paraguay: Ampi bis | Ampicilina | Ampicilina genfar | Ampicilina klonal | Ampicilina millet | Ampicilina sodica sanderson | Ampicilina veinfar | Ampicilina vivele | Ampimedin | Cilimpil | Cilimpil retard | Norake;
  • (QA) Qatar: Julphapen | Pamecil | Standacillin | Zcil;
  • (RO) Romania: Ampicilina | Ampicilina antibiotice | Ampicilina arena | Ampicilina forte | Ampicilina forte lph | Ampicilina sandoz | Ampidar | Ampisina | Ephicilin | Epicocillin | Standacillin;
  • (RU) Russian Federation: Ampic | Ampicillin | Ampicillin Akos | Ampicillin akos | Ampicillin ferein | Ampicillin forte | Ampicillin sodium salt | Ampicillin sodium salt vial | Ampiox natrii | Ampirex | Ampisid | Standacillin | Upsampi | Zetsyl;
  • (SA) Saudi Arabia: Ampidar | Epicocillin | Penbritin | Pentrexyl | Standacillin | Ultracillin;
  • (SE) Sweden: Doktacillin;
  • (SG) Singapore: Amcillin | Amillin | Ampicap | Ampicillin | Ampillin | Apo-Ampicillin | Dhacillin | Ficillin | Pamecil | Penbritin | Pricillin | Standacillin | Syntocil;
  • (SI) Slovenia: Ampicilina | Ampicillin | Ampicillin ratiopharm | Britapen | Gobemicina | Pan ampicillin | Penbritin;
  • (SK) Slovakia: Ampicillin | Penstabil | Pentrexyl;
  • (SL) Sierra Leone: Ampicin | Sino ampi;
  • (TH) Thailand: Ambicillin | Amcillin | Amcipen | Amilin | Amlin | Ampac | Ampat | Ampexin | Ampi | Ampi sol | Ampicillin | Ampicillin pharmacia | Ampicillin stada | Ampicin | Ampico | Ampicyn | Ampilin | Ampillin | Ampimycin | Ampin | Ampipen | Ampipen n.l. | Ampisil | Ampitrex | Ampolene | Ampolin | Ampota | Ampra mh | Amprexyl | Ampro | Amroycillin | Amtrex | Anbicillin | Bacin | Eracillin | Greatcillin | Indexil | Kempicin | Medicillin | Metro-am | Nadicillin | Neocillin | Overcillina | Pamecil | Penbritin | Pencotrex | Pentrexyl | Phihacillin | Phihamox | Picillin | Principen | Roscillin | Sanicillin | Siampicil | Specillin | Sumapen | Syntocil | Utocillin | Vacillin | Viccillin | Zampin;
  • (TN) Tunisia: Ampicil | Ampicyn | Opticilline | Pamecil | Penbritin | Rosampline | Sinapen | Totapen | Ultracilline;
  • (TR) Turkey: Alfasilin | Ampisina | Negopen | Penbisin | Seskasilin | Silina;
  • (TW) Taiwan: Ampicillin | Ampicyn | Ampiland | Ampimycin | Ampolin | Ancillin | Ancillina | Gobemicina | Hiperbiotico | Li cillin | Linpemycin | Pelitin | Penbritin | Pentrexyl | Servicillin | Standacillin | Tokiocillin | Winpicillin;
  • (UA) Ukraine: Amopen | Ampicil | Ampicillin | Brodaccillin | Novo Ampicillin | Standacillin;
  • (UG) Uganda: Agocilin | Agocillin | Ampecin | Ampilin | Ampiren | Ampirone | Ascillin | Kam ampi | Lacillin | Lampy | Milcillin | Spamcil | Swisscillin;
  • (UY) Uruguay: Ampicilina | Ampicyn | Binotal | Fada Ampicilina | Grampenil | Librampi | Maxicilina | Principen | Servicillin | Standacillin;
  • (VE) Venezuela, Bolivarian Republic of: Alampen | Ampenina | Ampicilina | Ampilan | Ampisod | Arcocilin | Bonasyl | Intrapen;
  • (VN) Viet Nam: Ampica | Franpicin;
  • (ZA) South Africa: Acupillin | Ampicillin | Ampicillin unimed | Ampicillin-blp | Ampicillin-fresenius | Ampipen | Auro ampicillin | Be-ampicil | Penbritin | Penrite | Petercillin | Ranamp | Rolab-ampicillin | Spectracil;
  • (ZM) Zambia: Ampicap | Ampicillin | Ampifil | Ampik | Ampikant | Ampishel | Apcillin | Ar ampi | Famicillin | Ipcacillin | Medampi | Petercillin | Spamcil | Zcil;
  • (ZW) Zimbabwe: Ampicelo | Ampicillin fresenius
  1. Ailes EC, Gilboa SM, Gill SK, et al; The National Birth Defects Prevention Study. Association between antibiotic use among pregnant women with urinary tract infections in the first trimester and birth defects, National Birth Defects Prevention Study 1997 to 2011. Birth Defects Res A Clin Mol Teratol. 2016;106(11):940-949. doi:10.1002/bdra.23570 [PubMed 27891788]
  2. American Academy of Pediatrics (AAP). In: Kimberlin DW, Barnett E, Lynfield R, Sawyer MH, eds. Red Book: 2021 Report of the Committee on Infectious Diseases. 32nd ed. American Academy of Pediatrics; 2021.
  3. American College of Obstetricians and Gynecologists (ACOG). ACOG Practice Bulletin No. 217: Prelabor rupture of membranes. Obstet Gynecol. 2020a;135(3):e80-e97. doi:10.1097/AOG.0000000000003700 [PubMed 32080050]
  4. American College of Obstetricians and Gynecologists (ACOG). ACOG Committee Opinion No. 797: Prevention of group B Streptococcal early-onset disease in newborns. Obstet Gynecol. 2020b;135(2):e51-e72. doi:10.1097/AOG.0000000000003668 [PubMed 31977795]
  5. American College of Obstetricians and Gynecologists (ACOG) Committee on Obstetric Practice. ACOG Practice Bulletin No. 199: Use of prophylactic antibiotics in labor and delivery. Obstet Gynecol. 2018;132(3):e103-e119. [PubMed 30134425]
  6. American College of Obstetricians and Gynecologists (ACOG) Committee on Obstetric Practice. ACOG Committee Opinion No. 712: Intrapartum management of intraamniotic infection. Obstet Gynecol. 2017;130(2):e95-e101. doi:10.1097/AOG.0000000000002236 [PubMed 28742677]
  7. American College of Obstetricians and Gynecologists (ACOG) Committee on Obstetric Practice. Committee Opinion No. 614: Management of pregnant women with presumptive exposure to Listeria monocytogenes. Obstet Gynecol. 2014;124(6):1241-1244. doi:10.1097/01.AOG.0000457501.73326.6c [PubMed 25411758]
  8. American Dental Association (ADA); American Academy of Orthopedic Surgeons (AAOS). Antibiotic prophylaxis for dental patients with total joint replacements. J Am Dent Assoc. 2003;134(7):895-899. [PubMed 12892448]
  9. Ampicillin oral [prescribing information]. Princeton, NJ: Sandoz Inc; August 2020.
  10. Ampicillin injection [prescribing information]. Buffalo Grove, IL: Xellia Pharmaceuticals USA LLC; August 2021.
  11. Ampicillin injection pharmacy bulk package [prescribing information]. Bethlehem, PA: Piramal Critical Care; August 2019.
  12. Arancibia A, Guttmann J, González G, González C. Absorption and disposition kinetics of amoxicillin in normal human subjects. Antimicrob Agents Chemother. 1980;17(2):199-202. doi:10.1128/aac.17.2.199 [PubMed 7387142]
  13. Aronoff GR, Bennett WM, Berns JS, et al. Drug Prescribing in Renal Failure: Dosing Guidelines for Adults and Children. 5th ed. American College of Physicians; 2007.
  14. Baddour LM, Chen AF. Prosthetic joint infection: Treatment. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed May 16, 2022.
  15. Baddour LM, Wilson WR, Bayer AS, et al; American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young, Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and Stroke Council. Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications: a scientific statement for healthcare professionals from the American Heart Association. Circulation. 2015;132(15):1435-1486. [PubMed 26373316]
  16. Baltimore RS, Gewitz M, Baddour LM, et al; American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young and the Council on Cardiovascular and Stroke Nursing. Infective endocarditis in childhood: 2015 update: a scientific statement from the American Heart Association. Circulation. 2015;132(15):1487-1515. doi:10.1161/CIR.0000000000000298 [PubMed 26373317]
  17. Barshak MB. Antimicrobial approach to intra-abdominal infections in adults. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed June 8, 2021.
  18. Beigi RH. Management and complications of tubo-ovarian abscess. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed November 19, 2021.
  19. Berardi A, Pietrangiolillo Z, Bacchi Reggiani ML, et al. Are postnatal ampicillin levels actually related to the duration of intrapartum antibiotic prophylaxis prior to delivery? A pharmacokinetic study in 120 neonates. Arch Dis Child Fetal Neonatal Ed. 2018;103(2):F152-F156. doi:10.1136/archdischild-2016-312546 [PubMed 28663282]
  20. Berbari EF, Kanj SS, Kowalski TJ, et al; Infectious Diseases Society of America. 2015 Infectious Diseases Society of America (IDSA) clinical practice guidelines for the diagnosis and treatment of native vertebral osteomyelitis in adults. Clin Infect Dis. 2015;61(6):e26-e46. doi:10.1093/cid/civ482 [PubMed 26229122]
  21. Bergan T. Pharmacokinetic comparison of oral bacampicillin and parenteral ampicillin. Antimicrob Agents Chemother. 1978;13(6):971-974. [PubMed 677863]
  22. Bilbao-Meseguer I, Rodríguez-Gascón A, Barrasa H, Isla A, Solinís MÁ. Augmented renal clearance in critically ill patients: a systematic review. Clin Pharmacokinet. 2018;57(9):1107-1121. doi:10.1007/s40262-018-0636-7 [PubMed 29441476]
  23. Blackwell BG, Leggett JE, Johnson CA, Zimmerman SW, Craig WA. Ampicillin and sulbactam pharmacokinetics and pharmacodynamics in continuous ambulatory peritoneal dialysis (CAPD). Perit Dial Int. 1990;10(3):221-226. [PubMed 2099158]
  24. Boguniewicz M, Leung DY. Hypersensitivity Reactions to Antibiotics Commonly Used in Children. Pediatr Infect Dis J. 1995;14(3):221-231. [PubMed 7761188]
  25. Bolme P, Dahlstrom B, Diding NA, Flink O, Paalzow L. Ampicillin: comparison of bioavailability and pharmacokinetics after oral and intravenous administration of three brands. J Clin Pharmacol. 1976;10:237-243.
  26. Bookstaver PB, Bland CM, Griffin B, Stover KR, Eiland LS, McLaughlin M. A review of antibiotic use in pregnancy. Pharmacotherapy. 2015;35(11):1052-1062. doi:10.1002/phar.1649 [PubMed 26598097]
  27. Bradley JS, Byington CL, Shah SS, et al. The Management of Community-Acquired Pneumonia in Infants and Children Older Than 3 Months of Age: Clinical Practice Guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America. Clin Infect Dis. 2011;53(7):e25-e76. [PubMed 21880587]
  28. Bradley JS, Nelson JD, Barnett ED, et al, eds. Nelson's Pediatric Antimicrobial Therapy. 29th ed. American Academy of Pediatrics; 2023.
  29. Bradley JS, Peacock G, Krug SE, et al. Pediatric anthrax clinical management. Pediatrics. 2014;133(5):e1411-e1436. doi:10.1542/peds.2014-0563 [PubMed 24777226]
  30. Bratzler DW, Dellinger EP, Olsen KM, et al; American Society of Health-System Pharmacists; Infectious Diseases Society of America; Surgical Infection Society; Society for Healthcare Epidemiology of America. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Am J Health Syst Pharm. 2013;70(3):195-283. [PubMed 23327981]
  31. Brown RD, Campoli-Richards DM. Antimicrobial Therapy in Neonates, Infants, and Children. Clin Pharmacokinet. 1989;17(suppl 1):105-115. [PubMed 2692934]
  32. Brumfield CG, Hauth JC, Andrews WW. Puerperal infection after cesarean delivery: evaluation of a standardized protocol. Am J Obstet Gynecol. 2000;182(5):1147-1151. doi:10.1067/mob.2000.103249 [PubMed 10819850]
  33. Burkart JM. Microbiology and therapy of peritonitis in peritoneal dialysis. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed June 21, 2022.
  34. Campbell AC, McElnay JC, Proceedings of the British Pharmacological Society. 12-14 September 1990, Belfast. The excretion of ampicillin in breast milk and its effect on the suckling infant. Br J Clin Pharmacol. 1991;31(2):217P-248P. doi:10.1111/j.1365-2125.1991.tb05523.x [PubMed 2049243]
  35. Centers for Disease Control and Prevention. CDC Health Information for International Travel 2014. Oxford University Press; 2014.
  36. Charlier C, Perrodeau É, Leclercq A, et al; MONALISA Study Group. Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study. Lancet Infect Dis. 2017;17(5):510-519. doi:10.1016/S1473-3099(16)30521-7 [PubMed 28139432]
  37. Chen KT. Postpartum endometritis. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed March 10, 2021.
  38. Chu VH. Antimicrobial therapy of left-sided native valve endocarditis. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed December 8, 2020.
  39. Cole KA, Kenney RM, Perri MB, et al. Outcomes of aminopenicillin therapy for vancomycin-resistant enterococcal urinary tract infections. Antimicrob Agents Chemother. 2015;59(12):7362-7366. doi:10.1128/AAC.01817-15 [PubMed 26369973]
  40. Craig WA. Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. Clin Infect Dis. 1998;26(1):1-10; quiz 11-12. doi:10.1086/516284 [PubMed 9455502]
  41. Craig WA. Post-antibiotic effects in experimental infection models: relationship to in-vitro phenomena and to treatment of infections in man. J Antimicrob Chemother. 1993;31(suppl D):149-158. doi:10.1093/jac/31.suppl_d.149 [PubMed 8335516]
  42. Crider KS, Cleves MA, Reefhuis J, Berry RJ, Hobbs CA, Hu DJ. Antibacterial medication use during pregnancy and risk of birth defects: National Birth Defects Prevention Study. Arch Pediatr Adolesc Med. 2009;163(11):978-985. doi:10.1001/archpediatrics.2009.188 [PubMed 19884587]
  43. Czeizel AE, Rockenbauer M, Sørensen HT, et al. A Population-Based Case-Control Teratologic Study of Ampicillin Treatment During Pregnancy. Am J Obstet Gynecol. 2001;185(1):140-147. [PubMed 11483918]
  44. Daly JS, Dodge RA, Glew RH, et al. Effect of Time and Temperature on Inactivation of Aminoglycosides by Ampicillin at Neonatal Dosages. J Perinatol. 1997;17(1):42-45. [PubMed 9069064]
  45. Damkier P, Brønniche LMS, Korch-Frandsen JFB, Broe A. In utero exposure to antibiotics and risk of congenital malformations: a population-based study. Am J Obstet Gynecol. 2019;221(6):648.e1-648.e15. doi:10.1016/j.ajog.2019.06.050 [PubMed 31260651]
  46. Expert opinion. Senior Renal Editorial Team: Bruce Mueller, PharmD, FCCP, FASN, FNKF; Jason A. Roberts, PhD, BPharm (Hons), B App Sc, FSHP, FISAC; Michael Heung, MD, MS.
  47. Fernández-Hidalgo N, Almirante B, Gavaldà J, et al. Ampicillin plus ceftriaxone is as effective as ampicillin plus gentamicin for treating Enterococcus faecalis infective endocarditis. Clin Infect Dis. 2013;56(9):1261-1268. doi:10.1093/cid/cit052 [PubMed 23392394]
  48. Gelfand MS. Treatment, prognosis, and prevention of Listeria monocytogenes infection. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed February 12, 2020.
  49. Graninger W, Ragette R. Nosocomial bacteremia due to Enterococcus faecalis without endocarditis. Clin Infect Dis. 1992;15(1):49-57. doi:10.1093/clinids/15.1.49 [PubMed 1617073]
  50. Gupta K. Acute simple cystitis in females. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed May 9, 2019a.
  51. Gupta K. Acute simple cystitis in adult males. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed September 5, 2019b.
  52. Gupta K, Hooton TM, Naber KG, et al; Infectious Diseases Society of America; European Society for Microbiology and Infectious Diseases. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis. 2011;52(5):e103-e120. doi:10.1093/cid/ciq257 [PubMed 21292654]
  53. Heinonen OP, Slone D, Shapiro S. Birth Defects and Drugs in Pregnancy. Littleton, MA: Publishing Sciences Group, Inc; 1977.
  54. Heintz BH, Halilovic J, Christensen CL. Vancomycin-resistant enterococcal urinary tract infections. Pharmacotherapy. 2010;30(11):1136-1149. [PubMed 20973687]
  55. Heintz BH, Matzke GR, Dager WE. Antimicrobial dosing concepts and recommendations for critically ill adult patients receiving continuous renal replacement therapy or intermittent hemodialysis. Pharmacotherapy. 2009;29(5):562-577. [PubMed 19397464]
  56. Hof H, Nichterlein T, Kretschmar M. Management of listeriosis. Clin Microbiol Rev. 1997;10(2):345-357. [PubMed 9105758]
  57. Hooton TM, Gupta K. Acute complicated urinary tract infection (including pyelonephritis) in adults. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed September 5, 2019c.
  58. Jevsevar DS, Abt E. The New AAOS-ADA Clinical Practice Guideline on Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures. J Am Acad Orthop Surg. 2013;21(3):195-197. [PubMed 23457071]
  59. Jusko WJ, Lewis GP, Schmitt GW. Ampicillin and hetacillin pharmacokinetics in normal and anephric subjects. Clin Pharmacol Ther. 1973;14(1):90-99. doi:10.1002/cpt197314190 [PubMed 4345622]
  60. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168(5):1393-9. doi:10.1016/s0002-9378(11)90771-6 [PubMed 8498418]
  61. Karchmer AW, Chu VH. Antimicrobial therapy of prosthetic valve endocarditis. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed November 24, 2020.
  62. Kubacka RT, Johnstone HE, Tan HS, Reeme PD, Myre SA. Intravenous ampicillin pharmacokinetics in the third trimester of pregnancy. Ther Drug Monit. 1983;5(1):55-60. doi:10.1097/00007691-198303000-00003 [PubMed 6845399]
  63. Lacy MK, Lu W, Xu X, et al. Pharmacodynamic comparisons of levofloxacin, ciprofloxacin, and ampicillin against streptococcus pneumoniae in an in vitro model of infection. Antimicrob Agents Chemother. 1999;43(3):672-677. doi:10.1128/AAC.43.3.672 [PubMed 10049286]
  64. Lamont HF, Blogg HJ, Lamont RF. Safety of antimicrobial treatment during pregnancy: a current review of resistance, immunomodulation and teratogenicity. Expert Opin Drug Saf. 2014;13(12):1569-1581. doi:10.1517/14740338.2014.939580 [PubMed 25189188]
  65. Le J, Greenberg RG, Yoo Y, et al. Ampicillin dosing in premature infants for early-onset sepsis: exposure-driven efficacy, safety, and stewardship. J Perinatol. 2022;42(7):959-964. doi:10.1038/s41372-022-01344-2 [PubMed 35210541]
  66. Lewis PO, Jones A, Amodei RJ, Youssef D. Continuous infusion ampicillin for the outpatient management of enterococcal endocarditis: a case report and literature review [published online October 16, 2018]. J Pharm Pract. doi:10.1177/0897190018804964 [PubMed 30326771]
  67. Li PK, Szeto CC, Piraino B, et al. ISPD peritonitis recommendations: 2016 update on prevention and treatment. Perit Dial Int. 2016;36(5):481-508. doi:10.3747/pdi.2016.00078 [PubMed 27282851]
  68. Li PK, Szeto CC, Piraino B, et al; International Society for Peritoneal Dialysis. Peritoneal dialysis-related infections recommendations: 2010 update. Perit Dial Int. 2010;30(4):393-423. doi:10.3747/pdi.2010.00049 [PubMed 20628102]
  69. Lorenzen JM, Broll M, Kaever V, et al. Pharmacokinetics of ampicillin/sulbactam in critically ill patients with acute kidney injury undergoing extended dialysis. Clin J Am Soc Nephrol. 2012;7(3):385-390. doi:10.2215/CJN.05690611 [PubMed 22223613]
  70. Mancini A, Todd L. Inconsistencies in ISPD peritonitis recommendations: 2016 update on prevention and treatment and the ISPD catheter-related infection recommendations: 2017 update. Perit Dial Int. 2018;38(4):309-310. doi:10.3747/pdi.2018.00026 [PubMed 29987068]
  71. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. [PubMed 6743732]
  72. Mazuski JE, Tessier JM, May AK, et al. The Surgical Infection Society revised guidelines on the management of intra-abdominal infection. Surg Infect (Larchmt). 2017;18(1):1-76. doi:10.1089/sur.2016.261 [PubMed 28085573]
  73. McNeeley SG, Hendrix SL, Mazzoni MM, Kmak DC, Ransom SB. Medically sound, cost-effective treatment for pelvic inflammatory disease and tuboovarian abscess. Am J Obstet Gynecol. 1998;178(6):1272-1278. doi:10.1016/s0002-9378(98)70333-3 [PubMed 9662312]
  74. Mermel LA, Allon M, Bouza E, et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;49(1):1-45. doi:10.1086/599376 [PubMed 19489710]
  75. Metlay JP, Waterer GW, Long AC, et al. Diagnosis and treatment of adults with community-acquired pneumonia. An official clinical practice guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Resp Crit Care Med. 2019;200(7):e45-e67. doi:10.1164/rccm.201908-1581ST [PubMed 31573350]
  76. Muanda FT, Sheehy O, Bérard A. Use of antibiotics during pregnancy and the risk of major congenital malformations: a population based cohort study. Br J Clin Pharmacol. 2017a;83(11):2557-2571. doi:10.1111/bcp.13364 [PubMed 28722171]
  77. Muanda FT, Sheehy O, Bérard A. Use of antibiotics during pregnancy and risk of spontaneous abortion. CMAJ. 2017b;189(17):E625-E633. doi:10.1503/cmaj.161020 [PubMed 28461374]
  78. Murray BE. Treatment of enterococcal infections. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed May 9, 2020.
  79. Nau H. Clinical pharmacokinetics in pregnancy and perinatology. II. Penicillins. Dev Pharmacol Ther. 1987;10(3):174-198. doi:10.1159/000457744 [PubMed 3301235]
  80. Nicolle LE, Gupta K, Bradley SF, et al. Clinical practice guideline for the management of asymptomatic bacteriuria: 2019 update by the Infectious Diseases Society of America. Clin Infect Dis. 2019;68(10):e83-e110. doi:10.1093/cid/ciy1121 [PubMed 30895288]
  81. Nishimura RA, Otto CM, Bonow RO, et al. 2017 AHA/ACC focused update of the 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2017;70(2):252-289. doi:10.1016/j.jacc.2017.03.011 [PubMed 28315732]
  82. Ogawa T, Kasahara K, Ikawa K, et al. Continuous ampicillin infusion as an alternative to intermittent infusion for adult inpatients: a case series. J Infect Chemother. 2014;20(10):653-655. doi: 10.1016/j.jiac.2014.05.006. [PubMed 24972584]
  83. Osmon DR, Berbari EF, Berendt AR, et al. Diagnosis and management of prosthetic joint infection: clinical practice guideline by the Infectious Diseases Society of America. Clin Infect Dis. 2013;56(1):e1-e25. [PubMed 23223583]
  84. Osmon DR, Tande AJ. Osteomyelitis in adults: Treatment. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed May 9, 2019.
  85. Puhó EH, Szunyogh M, Métneki J, et al. Drug Treatment During Pregnancy and Isolated Orofacial Clefts in Hungary. Cleft Palate Craniofac J. 2007;44(2):194-202. [PubMed 17328645]
  86. Puopolo KM, Benitz WE, Zaoutis TE; Committee on Fetus and Newborn; Committee on Infectious Diseases. Management of Neonates Born at ≤34 6/7 Weeks' Gestation With Suspected or Proven Early-Onset Bacterial Sepsis. Pediatrics. 2018a;142(6). pii: e20182896. [PubMed 30455344]
  87. Puopolo KM, Benitz WE, Zaoutis TE; Committee on Fetus and Newborn; Committee on Infectious Diseases. Management of Neonates Born at ≥35 0/7 Weeks' Gestation With Suspected or Proven Early-Onset Bacterial Sepsis. Pediatrics. 2018b;142(6). pii: e20182894. [PubMed 30455342]
  88. Puopolo KM, Lynfield R, Cummings JJ; Committee on Fetus and Newborn; Committee on Infectious Diseases. Management of infants at risk for group B streptococcal disease [published correction appears in Pediatrics. 2019 Oct;144(4):]. Pediatrics. 2019;144(2):e20191881. doi:10.1542/peds.2019-1881 [PubMed 31285392]
  89. Refer to manufacturer labeling.
  90. Roberts JA, Paul SK, Akova M, et al; DALI Study. DALI: defining antibiotic levels in intensive care unit patients: are current β-lactam antibiotic doses sufficient for critically ill patients? Clin Infect Dis. 2014;58(8):1072-1083. doi:10.1093/cid/ciu027 [PubMed 24429437]
  91. Ruedy J. The effects of peritoneal dialysis on the physiological disposition of oxacillin, ampicillin and tetracycline in patients with renal disease. Can Med Assoc J. 1966;94(6):257-261. [PubMed 5903164]
  92. Sawyer RG, Claridge JA, Nathens AB, et al; STOP-IT Trial Investigators. Trial of short-course antimicrobial therapy for intraabdominal infection. N Engl J Med. 2015;372(21):1996-2005. doi:10.1056/NEJMoa1411162 [PubMed 25992746]
  93. Shaffer CL, Davey AM, Ransom JL, et al. Ampicillin-Induced Neurotoxicity in Very-Low-Birth-Weight Neonates. Ann Pharmacother. 1998;32(4):482-484. [PubMed 9562146]
  94. Shah KJ, Cherabuddi K, Shultz J, Borgert S, Ramphal R, Klinker KP. Ampicillin for the treatment of complicated urinary tract infections caused by vancomycin-resistant Enterococcus spp (VRE): a single-center university hospital experience. Int J Antimicrob Agents. 2018;51(1):57-61. doi:10.1016/j.ijantimicag.2017.06.008 [PubMed 28666756]
  95. Sheffield MJ, Lambert DK, Baer VL, et al. Effect of ampicillin on bleeding time in very low birth-weight neonates during the first week after birth. J Perinatol. 2011;31(7):477-480. doi:10.1038/jp.2010.154 [PubMed 21372796]
  96. Sheffield MJ, Lambert DK, Henry E, Christensen RD. Effect of ampicillin on the bleeding time of neonatal intensive care unit patients. J Perinatol. 2010;30(8):527-530. doi:10.1038/jp.2009.192 [PubMed 20043011]
  97. Sollecito TP, Abt E, Lockhart PB, et al. The use of prophylactic antibiotics prior to dental procedures in patients with prosthetic joints: Evidence-based clinical practice guideline for dental practitioners--a report of the American Dental Association Council on Scientific Affairs. J Am Dent Assoc. 2015;146(1):11-16. [PubMed 25569493]
  98. Solomkin JS, Mazuski JE, Bradley JS, et al. Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Clin Infect Dis. 2010;50(2):133-164. doi:10.1086/649554 [PubMed 20034345]
  99. Syed Q, Hendler KT, Koncilja K. The Impact of Aging and Medical Status on Dysgeusia. Am J Med. 2016;129(7):753.e1-6.
  100. Szeto CC, Li PK. Concerns regarding inconsistencies within and between ISPD recommendations for peritonitis and catheter-related infections-in reply. Perit Dial Int. 2018;38(4):311-312. doi:10.3747/pdi.2018.00046 [PubMed 29987069]
  101. Tita ATN. Intraamniotic infection (clinical chorioamnionitis). Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed July 27, 2022.
  102. Tremoulet A, Le J, Poindexter B, et al. Characterization of the population pharmacokinetics of ampicillin in neonates using an opportunistic study design. Antimicrob Agents Chemother. 2014;58(6):3013-3020. [PubMed 24614374]
  103. Tunkel AR, Hartman BJ, Kaplan SL, et al. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis. 2004;39(9):1267-1284. [PubMed 15494903]
  104. Tunkel AR, Hasbun R, Bhimraj A, et al. 2017 Infectious Diseases Society of America's clinical practice guidelines for healthcare-associated ventriculitis and meningitis. Clin Infect Dis. 2017;64(6):34-65. doi:10.1093/cid/ciw861 [PubMed 28203777]
  105. Udy AA, Roberts JA, Boots RJ, Paterson DL, Lipman J. Augmented renal clearance: implications for antibacterial dosing in the critically ill. Clin Pharmacokinet. 2010;49(1):1-16. doi:10.2165/11318140-000000000-00000 [PubMed 20000886]
  106. Vermont Oxford Network (VON). Neonatal drug concentrations. Updated November 2022. Accessed October 24, 2023. https://public.vtoxford.org/neonatal-drug-concentrations
  107. Warady BA, Bakkaloglu S, Newland J, et al. Consensus Guidelines for the Prevention and Treatment of Catheter-Related Infections and Peritonitis in Pediatric Patients Receiving Peritoneal Dialysis: 2012 Update. Perit Dial Int. 2012;32(suppl 2):S32-S86. [PubMed 22851742]
  108. Wilson WR, Gewitz M, Lockhart PB, et al; American Heart Association Young Hearts Rheumatic Fever, Endocarditis and Kawasaki Disease Committee of the Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Cardiovascular and Stroke Nursing; and the Council on Quality of Care and Outcomes Research. Prevention of viridans group streptococcal infective endocarditis: a scientific statement from the American Heart Association. Circulation. 2021;143(20):e963-e978. doi:10.1161/CIR.0000000000000969 [PubMed 33853363]
  109. Wilson W, Taubert KA, Gewitz M, et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2007;116(15):1736-1754. [PubMed 17446442]
  110. Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm Rep. 2021;70(4):1-187. doi:10.15585/mmwr.rr7004a1 [PubMed 34292926]
  111. World Health Organization (WHO). Breastfeeding and maternal medication, recommendations for drugs in the eleventh WHO model list of essential drugs. 2002. http://www.who.int/maternal_child_adolescent/documents/55732/en/
  112. Wright N, Wise R. The elimination of sulbactam alone and combined with ampicillin in patients with renal dysfunction. J Antimicrob Chemother. 1983;11(6):583-587. doi:10.1093/jac/11.6.583 [PubMed 6309731]
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