Version July 2025
Serious, including fatal, pancytopenia/marrow hypoplasia, autoimmune idiopathic thrombocytopenia, and autoimmune hemolytic anemia can occur in patients receiving alemtuzumab. Single doses of alemtuzumab >30 mg or cumulative doses >90 mg per week increase the incidence of pancytopenia.
Alemtuzumab administration can result in serious, including fatal, infusion reactions. Carefully monitor patients during infusions and withhold alemtuzumab for Grade 3 or 4 infusion reactions. Gradually escalate alemtuzumab to the recommended dose at the initiation of therapy and after interruption of therapy for ≥7 days.
Serious, including fatal, bacterial, viral, fungal, and protozoan infections can occur in patients receiving alemtuzumab. Administer prophylaxis against Pneumocystis jirovecii pneumonia and herpes virus infections.
Alemtuzumab causes serious, sometimes fatal, autoimmune conditions, such as immune thrombocytopenia and anti-glomerular basement membrane disease. Monitor CBC with differential, serum creatinine levels, and urinalysis with urine cell counts before starting treatment and then at monthly intervals until 48 months after the last dose of alemtuzumab.
Alemtuzumab causes serious and life-threatening infusion reactions. Alemtuzumab must be administered in a setting with appropriate equipment and personnel to manage anaphylaxis or serious infusion reactions. Monitor patients for 2 hours after each infusion. Make patients aware that serious infusion reactions can also occur after the 2-hour monitoring period.
Alemtuzumab may cause an increased risk of malignancies, including thyroid cancer, melanoma, and lymphoproliferative disorders. Perform baseline and yearly skin exams.
Because of the risk of autoimmunity, infusion reactions, and malignancies, Lemtrada is available only through restricted distribution under a Risk Evaluation Mitigation Strategy (REMS) Program. Call 1-855-676-6326 to enroll in the Lemtrada REMS program.
Serious and life-threatening stroke (including ischemic and hemorrhagic stroke) has been reported within 3 days of alemtuzumab administration. Instruct patients to seek immediate medical attention if symptoms of stroke occur.
Dosage guidance:
Safety: Premedications are recommended.
Clinical considerations: Alemtuzumab is associated with a moderate emetic potential in the oncology setting; antiemetics may be recommended to prevent nausea and vomiting (Ref). Prophylaxis against opportunistic infections should be implemented based on indication and patient specific factors. For oncology indications, Pneumocystis jirovecii pneumonia (PCP) prophylaxis is recommended during alemtuzumab treatment and for at least 2 months following last dose or until CD4+ counts are ≥200/mm3 (whichever is later). For oncology indications and multiple sclerosis, herpes virus prophylaxis is recommended during alemtuzumab treatment and for at least 2 months following last dose or until CD4+ counts are ≥200 mm3 (whichever is later).
B-cell chronic lymphocytic leukemia (CLL): Campath, MabCampath [Canadian product]: IV: Gradually escalate to a maintenance of 30 mg per dose 3 times weekly on alternate days for a total duration of therapy of up to 12 weeks (Ref).
Note: Dose escalation is required; usually accomplished in 3 to 7 days. Single doses >30 mg or cumulative doses >90 mg/week increase the incidence of pancytopenia. Pretreatment (with acetaminophen 500 to 1,000 mg and diphenhydramine 50 mg) is recommended 30 minutes prior to the first dose, with dose escalations, and as clinically indicated; IV glucocorticoids may be used for severe infusion-related reactions. Administer antiviral prophylaxis (for herpetic viral infections) and PCP prophylaxis; continue for at least 2 months after completion of alemtuzumab and until CD4+ lymphocyte count is ≥200/mm3. Reinitiate with gradual dose escalation if treatment is withheld ≥7 days.
Dose escalation: IV: Initial: 3 mg daily beginning on day 1; if tolerated (infusion reaction ≤ grade 2), increase to 10 mg daily; if tolerated (infusion reaction ≤ grade 2), may increase to maintenance of 30 mg per dose 3 times weekly (on alternate days) if required.
B-cell CLL (off-label route): Campath: SUBQ: Initial: 3 mg on day 1; if tolerated 10 mg on day 3; if tolerated increase to 30 mg on day 5; maintenance: 30 mg per dose 3 times weekly on alternate days for a maximum of 18 weeks (Ref) or 3 mg on day 1; if tolerated 10 mg on day 2; if tolerated 30 mg on day 3, followed by 30 mg per dose 3 times weekly on alternate days for 4 to 12 weeks (Ref).
Multiple sclerosis, relapsing:
Note: Safety: In high-risk populations or in countries with high tuberculosis burden, screen for latent infections (eg, hepatitis, tuberculosis) prior to initiating therapy. For patients who screen positive for latent infections, consult infectious disease or other appropriate specialists (eg, liver specialists) regarding treatment options before initiating therapy (Ref). Administer antiviral prophylaxis (for herpetic viral infections) beginning on the first day of treatment and continue for at least 2 months after completion of alemtuzumab or until CD4+ lymphocyte count is ≥200/mm3 (whichever occurs later). Premedication: Premedicate with corticosteroids (methylprednisolone 1 g or equivalent) immediately prior to alemtuzumab for the first 3 days of each treatment course. Antihistamines and/or antipyretics may also be considered.
Lemtrada: IV: 12 mg daily for 5 consecutive days (total 60 mg), followed 12 months later by 12 mg daily for 3 consecutive days (total 36 mg). Subsequent treatment courses of 12 mg daily for 3 consecutive days (total 36 mg) may be administered if necessary; courses should be administered no earlier than 12 months after the last dose of the prior treatment cycle.
Aplastic anemia, refractory (off-label use): Campath:
IV: 10 mg daily for 10 days (as monotherapy); patients received a 1 mg test dose initially (Ref) or
SUBQ: 3 mg day 1, 10 mg day 2, then 30 mg/day days 3, 4, and 5 (total dose: 103 mg over 5 consecutive days; in combination with cyclosporine) (Ref).
Autoimmune cytopenias, chronic lymphocytic leukemia induced, refractory (off-label use): Campath: IV, SUBQ: Gradually escalate to a maintenance of 10 to 30 mg per dose 3 times weekly for 4 to 12 weeks (Ref).
Hemophagocytic lymphohistiocytosis, refractory (off-label use): Campath: Note: The optimal dose and duration of therapy is not known. Median dose: IV, SUBQ: 1 mg/kg (range 0.1 to 8.9 mg/kg; maximum initial dose: 3 mg) divided over a median of 4 days (range 2 to 10 days); refer to article for further information (Ref).
Mycosis fungoides/Sézary syndrome, advanced (off-label use): Campath: IV: Initial: 3 mg, increase to 10 mg and then to 30 mg as soon as infusion-related reactions were tolerated; Maintenance: 30 mg 3 times weekly for up to 12 weeks, or until complete remission is achieved or disease progression is noted; for dosing interruptions >7 days due to toxicity, reinitiate at 3 or 10 mg (Ref).
Solid organ transplantation: Campath:
Heart transplant, induction (off-label use): IV: 30 mg once intra-operatively at the time of transplant followed by minimized maintenance immunosuppression (Ref).
Intestine transplant, induction (off-label use): Note: Optimal dose, frequency, and duration of therapy have not been established and vary based on institutional protocols. Administer as part of an appropriate combination regimen. An example regimen is provided.
IV: 30 mg administered intraoperatively at induction of anesthesia for the transplant procedure (Ref).
Kidney transplant, induction (off-label use): IV: 30 mg as a single dose at the time of transplant (immediately following reperfusion) followed by a second 30 mg dose 24 hours later (the second dose was omitted in patients >60 years of age); followed by minimized maintenance immunosuppression (Ref).
Kidney transplant, steroid-resistant cellular rejection (off-label use): IV, SUBQ: 15 to 30 mg/dose SUBQ on 2 subsequent days (Ref) or 30 mg/dose IV over 2 to 4 hours for 1 to 2 doses (Ref).
Lung transplant, induction (off-label use): IV, SUBQ: 30 mg once either immediately before allograft reperfusion or immediately following transplant; followed by minimized maintenance immunosuppression (Ref).
Lung transplant, refractory rejection, treatment (adjunctive) (off-label use): Note: Optimal dose, frequency, and duration of therapy have not been established and vary based on institutional protocols. Administer as part of an appropriate combination regimen. An example regimen is provided.
IV: 30 mg administered as a single dose (Ref).
Multivisceral transplant, induction (off-label use): Note: Optimal dose, frequency, and duration of therapy have not been established and vary based on institutional protocols. Administer as part of an appropriate combination regimen. An example regimen is provided.
IV: 30 mg administered intraoperatively at induction of anesthesia for the transplant procedure (Ref).
Pancreas transplant, induction (off-label use): Note: Optimal dose, frequency, and duration of therapy have not been established and vary based on institutional protocols. Administer as part of an appropriate combination regimen. An example regimen is provided.
IV: 30 mg administered intraoperatively during the transplant procedure (Ref).
T-cell large granular lymphocytic leukemia (off-label use): Campath: IV: 10 mg daily for 10 days; patients received a 1 mg test dose initially (Ref).
T-cell prolymphocytic leukemia (off-label use): Campath:
Refractory disease: IV: Initial test dose 3 mg or 10 mg, followed by dose escalation to 30 mg per dose 3 times weekly as tolerated until maximum response (Ref) or Initial dose: 3 mg on day 1, if tolerated increase to 10 mg on day 2, if tolerated increase to 30 mg on day 3 (days 1, 2, and 3 are consecutive days), followed by 30 mg per dose every Monday, Wednesday, Friday for a total of 4 to 12 weeks (Ref).
Consolidation (following FMC [fludarabine, mitoxantrone, and cyclophosphamide] induction chemotherapy): Initial dose: IV: 3 mg on day 1, if tolerated increase to 10 mg on day 2, if tolerated increase to 30 mg on day 3, followed by 30 mg per dose 3 times a week for up to 12 weeks (Ref). Refer to protocol for FMC cycle details, when alemtuzumab is initiated, and monitoring.
Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.
There are no dosage adjustments provided in the manufacturer's labeling (has not been studied).
Hepatic impairment prior to treatment: There are no dosage adjustments provided in the manufacturer's labeling (has not been studied).
Hepatic impairment during treatment: Hepatitis: Promptly obtain serum transaminases and total bilirubin; may require alemtuzumab interruption or discontinuation.
American Society for Blood and Marrow Transplantation practice guideline committee position statement on chemotherapy dosing in adults with a BMI ≥30 kg/m2: Utilize a flat dose based on the regimen selected for hematopoietic cell transplant conditioning in adults (Ref).
Dosage adjustment for nonhematologic toxicity:
Treatment of B-CLL: Campath, MabCampath [Canadian product]:
Note: If treatment is withheld ≥7 days, reinitiate at 3 mg with re-escalation to 10 mg and then 30 mg.
Grade 3 or 4 infusion reaction: Withhold infusion; medications for the treatment of infusion reactions should be available for immediate use.
Infection, serious: Withhold alemtuzumab until resolution; may be reinitiated upon resolution of infection. For cytomegalovirus (CMV) infection or confirmed CMV viremia, withhold alemtuzumab and initiate appropriate antiviral treatment.
Autoimmune anemia or autoimmune thrombocytopenia: Discontinue alemtuzumab.
Other serious adverse reaction: Withhold alemtuzumab until resolution.
Treatment of MS: Lemtrada:
Adult-onset Still disease: Discontinue alemtuzumab if alternate etiology cannot be established.
Autoimmune encephalitis: Discontinue alemtuzumab if suspected or confirmed by the presence of neural autoantibodies.
Progressive multifocal leukoencephalopathy: Perform a diagnostic evaluation at the first sign or symptom suggestive of progressive multifocal leukoencephalopathy and withhold alemtuzumab.
Serious infusion reaction: Consider immediate discontinuation.
Dosage adjustment for hematologic toxicity (severe neutropenia or thrombocytopenia, not autoimmune): Treatment of B-CLL: Campath, MabCampath [Canadian product]:
Note: If treatment is withheld ≥7 days, reinitiate at 3 mg with re-escalation to 10 mg and then 30 mg.
ANC <250/mm3 and/or platelet count ≤25,000/mm3:
First occurrence: Withhold treatment; resume at 30 mg per dose when ANC ≥500/mm3 and platelet count ≥50,000/mm3.
Second occurrence: Withhold treatment; resume at 10 mg per dose when ANC ≥500/mm3 and platelet count ≥50,000/mm3.
Third occurrence: Discontinue alemtuzumab.
Patients with a baseline ANC ≤250/mm3 and/or a baseline platelet count ≤25,000/mm3 at initiation of therapy: If ANC and/or platelet counts decrease by ≥50% of the baseline value:
First occurrence: Withhold treatment; resume at 30 mg per dose upon return to baseline values.
Second occurrence: Withhold treatment; resume at 10 mg per dose upon return to baseline values.
Third occurrence: Discontinue alemtuzumab.
Hemophagocytic lymphohistiocytosis: Discontinue alemtuzumab if alternate etiology of signs/symptoms cannot be established.
Thrombotic thrombocytopenic purpura: Discontinue alemtuzumab if thrombotic thrombocytopenic purpura is confirmed or if alternate etiology of signs/symptoms cannot be established.
Refer to adult dosing.
Aplastic anemia, refractory (off-label use): Campath:
Children ≥2 years of age and Adolescents (<50 kg): IV: 0.2 mg/kg/dose (maximum: 10 mg/dose) for 10 days (as monotherapy); patients received a 1 mg test dose initially (Ref)
Children ≥2 years of age and Adolescents (≥50 kg): IV: 10 mg daily for 10 days (as monotherapy); patients received a 1 mg test dose initially (Ref)
Hemophagocytic lymphohistiocytosis, refractory (off-label use): Infants, Children, and Adolescents: Campath: IV, SubQ: Note: The optimal dose and duration of therapy is not known. Median dose: 1 mg/kg (range 0.1 to 8.9 mg/kg; maximum initial dose: 3 mg) divided over a median of 4 days (range 2 to 10 days); refer to article for further information (Ref)
Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.
Dosing adjustment for toxicity: There are no pediatric-specific recommendations; the presented dosing adjustments are based on experience in adult patients. Refer to specific protocol for management in pediatric patients if available.
Nonhematologic toxicity:
Treatment of B-CLL: Campath, MabCampath [Canadian product]:
Note: If treatment is withheld ≥7 days, reinitiate at 3 mg with re-escalation to 10 mg and then 30 mg.
Grade 3 or 4 infusion reaction: Withhold infusion
Serious infection or other serious adverse reaction: Withhold alemtuzumab until resolution
Autoimmune anemia or autoimmune thrombocytopenia: Discontinue alemtuzumab
Hematologic toxicity (severe neutropenia or thrombocytopenia, not autoimmune): Treatment of B-CLL: Campath, MabCampath [Canadian product]:
Note: If treatment is withheld ≥7 days, reinitiate at 3 mg with re-escalation to 10 mg and then 30 mg.
ANC <250/mm3 and/or platelet count ≤25,000/mm3:
First occurrence: Withhold treatment; resume at 30 mg per dose when ANC ≥500/mm3 and platelet count ≥50,000/mm3
Second occurrence: Withhold treatment; resume at 10 mg per dose when ANC ≥500/mm3 and platelet count ≥50,000/mm3
Third occurrence: Discontinue alemtuzumab.
Patients with a baseline ANC ≤250/mm3 and/or a baseline platelet count ≤25,000/mm3 at initiation of therapy: If ANC and/or platelet counts decrease by ≥50% of the baseline value:
First occurrence: Withhold treatment; resume at 30 mg per dose upon return to baseline values
Second occurrence: Withhold treatment; resume at 10 mg per dose upon return to baseline values
Third occurrence: Discontinue alemtuzumab.
There are no dosage adjustments provided in the manufacturer’s labeling (has not been studied).
There are no dosage adjustments provided in the manufacturer’s labeling (has not been studied).
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Adverse reactions reported in adults.
Multiple sclerosis:
>10%:
Dermatologic: Pruritus (14%), skin rash (53%), urticaria (16%)
Endocrine & metabolic: Thyroid disease (13% to 37%; including goiter, Graves disease, hyperthyroidism, hypothyroidism, thyroiditis)
Gastrointestinal: Diarrhea (12%), nausea (21%)
Genitourinary: Urinary tract infection (19%)
Hematologic & oncologic: Lymphocytopenia (100%)
Hypersensitivity: Infusion-related reaction (92%; severe infusion-related reaction: 3%)
Immunologic: Antibody development (neutralizing: 5% to 94%; anti-alemtuzumab: 29% to 83%; no significant effect on drug efficacy)
Infection: Fungal infection (12% to 13%; including oral candidiasis, vulvovaginal candidiasis), herpes virus infection (16%), infection (71%; serious infection: 3%)
Nervous system: Fatigue (18%), headache (52%), insomnia (16%)
Neuromuscular & skeletal: Arthralgia (12%), back pain (12%), limb pain (12%)
Respiratory: Nasopharyngitis (25%), oropharyngeal pain (11%), sinusitis (11%), upper respiratory tract infection (16%)
Miscellaneous: Fever (29%)
1% to 10%:
Cardiovascular: Chest discomfort (7%), flushing (10%), peripheral edema (5%), tachycardia (8%)
Dermatologic: Dermatitis (8%), erythema of skin (5%)
Gastrointestinal: Abdominal pain (10%), appendicitis (≤3%), dysgeusia (8%), dyspepsia (8%), gastroenteritis (≤3%), oral herpes simplex infection (9%), tooth infection (≤3%), vomiting (10%)
Genitourinary: Abnormal uterine bleeding (5%), genital herpes simplex (1%), microscopic hematuria (8%)
Hematologic & oncologic: Decreased CD-4 cell count (6%), decreased CD-8 cell counts (6%), decreased T-cell lymphocytes (5%), immune thrombocytopenia (2%)
Hypersensitivity: Angioedema (≤3%)
Infection: Herpes simplex infection (2%), herpes zoster infection (4%), human papilloma virus infection (2%), influenza (8%)
Nervous system: Anxiety (7%), asthenia (5%), chills (9%), dizziness (10%), myasthenia (7%), paresthesia (10%)
Neuromuscular & skeletal: Muscle spasm (6%), myalgia (6%), neck pain (5%)
Ophthalmic: Graves ophthalmopathy (2%)
Respiratory: Bronchitis (7%), cough (9%), dyspnea (8%), epistaxis (5%), pneumonia (≤3%)
<1%:
Dermatologic: Malignant melanoma, vitiligo
Endocrine & metabolic: Thyroid neoplasm, type 1 diabetes mellitus
Gastrointestinal: Cholecystitis (calculous and acalculous)
Hematologic & oncologic: Acquired blood coagulation disorder (hemophilia A [anti-Factor VIII antibodies]), hemolytic anemia (including autoimmune hemolytic anemia), neutropenia, pancytopenia
Hypersensitivity: Anaphylactic shock, anaphylaxis
Immunologic: Anti-GBM disease
Infection: Varicella zoster infection
Nervous system: Meningitis (herpes), suicidal ideation, suicidal tendencies
Neuromuscular & skeletal: Connective tissue disease (undifferentiated), rheumatoid arthritis
Ophthalmic: Retinal pigment changes (epitheliopathy)
Renal: Membranous glomerulonephritis
Respiratory: Pneumonitis (including with fibrosis, hypersensitivity pneumonitis), tuberculosis
B-cell chronic lymphocytic leukemia:
>10%:
Cardiovascular: Cardiac arrhythmia (14%), hypertension (14%), hypotension (16%)
Dermatologic: Skin rash (13%), urticaria (16%)
Hematologic & oncologic: Anemia (76%; grades 3/4: 12% to 38%), lymphocytopenia (97%; grades 3/4: 97%), neutropenia (77%; grades 3/4: 42% to 64%), thrombocytopenia (71%; grades 3/4: 13% to 52%)
Hypersensitivity: Infusion-related reaction (more frequently seen in the first week of treatment)
Infection: CMV viremia (55%), cytomegalovirus disease (6% to 16%), infection (50% to 74%)
Nervous system: Chills (53%), headache (14%)
Respiratory: Dyspnea (14%)
Miscellaneous: Fever (69%)
1% to 10%:
Cardiovascular: Tachycardia (10%)
Dermatologic: Erythema of skin (4%)
Gastrointestinal: Anorexia (>5%), diarrhea (10%), nausea (>5%), stomatitis (>5%), vomiting (>5%)
Hematologic & oncologic: Autoimmune thrombocytopenia (2%), febrile neutropenia (grades ≥3: 5% to 10%)
Immunologic: Antibody development (2% to 8%; neutralizing: 2%)
Infection: Sepsis (grades ≥3: 3% to 10%)
Nervous system: Anxiety (8%), dysesthesia (>5%), fatigue (>5%), insomnia (10%), tremor (3%)
Neuromuscular & skeletal: Musculoskeletal pain (>5%)
Respiratory: Bronchospasm (>5%)
Frequency not defined: Gastrointestinal: Abdominal pain
Postmarketing (all indications):
Cardiovascular: Acute myocardial infarction, cardiac insufficiency (acute), cardiomyopathy, coronary artery dissection (cervicocephalic arterial dissection [vertebral, carotid]), heart failure, ischemic heart disease, reduced ejection fraction, syncope, vasculitis
Dermatologic: Alopecia
Gastrointestinal: Colitis (may be severe)
Hematologic & oncologic: Aplastic anemia, bone marrow aplasia, bone marrow depression (prolonged), hemophagocytic lymphohistiocytosis, lymphoproliferative disorder, malignant lymphoma, pure red cell aplasia, thrombotic thrombocytopenic purpura, tumor lysis syndrome
Hepatic: Autoimmune hepatitis, viral hepatitis
Hypersensitivity: Serum sickness
Immunologic: Epstein-Barr-associated lymphoproliferative disorder, graft-versus-host disease (transfusion associated), sarcoidosis
Infection: Epstein-Barr infection, listeriosis (including gastroenteritis, encephalitis, sepsis), opportunistic infection (including aspergillosis, coccidioidomycosis, histoplasmosis, nocardiosis)
Nervous system: Cerebrovascular accident, chronic inflammatory demyelinating polyneuropathy, encephalitis (autoimmune), Guillain-Barré syndrome, intracranial hemorrhage, ischemic stroke, meningitis due to Listeria monocytogenes, myasthenia gravis, progressive multifocal leukoencephalopathy
Neuromuscular & skeletal: Arthritis (adult-onset Still disease), Lambert-Eaton syndrome
Ophthalmic: Optic neuropathy
Respiratory: Acute respiratory distress syndrome, apnea, pneumonia due to Pneumocystis jirovecii, pulmonary alveolar hemorrhage, pulmonary infiltrates
Miscellaneous: Reactivation of disease
US labeling: Hypersensitivity (eg, anaphylactic reactions) to alemtuzumab or any component of the formulation; HIV infection (due to prolonged reduction in CD4+ lymphocytes); active infection. There are no contraindications listed in the manufacturer's Campath labeling.
Canadian labeling:
Lemtrada: Hypersensitivity to alemtuzumab or any component of the formulation; HIV infection; tuberculosis (TB) disease (active TB) or infection (latent TB); severe active infections; active malignancies; concurrent anticoagulant, antiplatelet, antineoplastic, or immunosuppressive therapy; history of progressive multifocal leukoencephalopathy (PML); history of stroke and arterial dissection of cervicocephalic arteries; uncontrolled hypertension; history of angina or myocardial infarction; known coagulopathy.
MabCampath: Known type 1 hypersensitivity or anaphylactic reactions to alemtuzumab or any component of the formulation; active infections; underlying immunodeficiency (eg, seropositive for HIV); active secondary malignancies; current or history of PML.
Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.
Concerns related to adverse effects:
• Adult-onset Still disease: Rare cases of adult-onset Still disease have been reported in patients receiving alemtuzumab for multiple sclerosis. Promptly evaluate patients with signs and symptoms (eg, fever, arthritis, rash, leukocytosis in the absence of infections, malignancies, or other rheumatic conditions) suggestive of adult-onset Still disease.
• Autoimmune effects: Alemtuzumab causes serious, sometimes fatal, autoimmune conditions, such as immune thrombocytopenia and antiglomerular basement membrane (anti-GBM) disease, in patients receiving alemtuzumab for the treatment of multiple sclerosis (MS). Glomerular nephropathies, including anti-GBM disease, have been reported up to 40 months after the last dose. Glomerular nephropathies require urgent evaluation; may lead to end-stage renal disease requiring dialysis or renal transplantation if not treated. Urine dipstick results of ≥1+ protein warrant assessment of urine protein to creatinine ratio. Perform further evaluation for nephropathies if urine protein to creatinine ratio >200 mg/g, increase in serum creatinine >30%, or unexplained hematuria. Alveolar hemorrhage manifesting as hemoptysis has been reported with anti-GBM disease. Prompt intervention is necessary for increased serum creatinine with hematuria, signs of pulmonary involvement of anti-GBM disease (eg, hemoptysis, exertional dyspnea), or autoimmune cytopenias. Immune thrombocytopenia (formerly known as idiopathic thrombocytopenic purpura), thrombotic thrombocytopenic purpura (TTP), thyroid disorders, autoimmune encephalitis, autoimmune hemolytic anemia, autoimmune hepatitis, autoimmune pancytopenia, undifferentiated connective tissue disorders, acquired hemophilia A, rheumatoid arthritis, type 1 diabetes, vasculitis, vitiligo, and retinal pigment epitheliopathy have been reported in patients receiving alemtuzumab for MS. Guillain-Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy have been reported in patients receiving alemtuzumab for other uses. Alemtuzumab may increase the risk for other autoimmune conditions.
• Autoimmune encephalitis: Autoimmune encephalitis, including signs and symptoms of altered mental status, subacute onset of memory impairment, neurological findings, psychiatric symptoms, and seizures, has been reported.
• Bone marrow suppression: Severe prolonged myelosuppression, hemolytic anemia, pure red cell aplasia, bone marrow aplasia, and bone marrow hypoplasia have also been reported with use at the normal dose for the treatment of B-cell chronic lymphocytic leukemia (B-CLL). Patients receiving blood products should only receive irradiated blood products due to the potential for transfusion-associated graft-versus-host disease during lymphopenia.
• Cholecystitis: In a clinical trial of patients with MS, an increased risk of acute acalculous cholecystitis was observed in patients receiving alemtuzumab versus interferon beta-1a; additional postmarketing cases have also been reported. Symptom onset ranged from <24 hours to 2 months after alemtuzumab infusion. Some patients recovered without surgical intervention (and received antibiotics); some patients underwent cholecystectomy. Monitor closely (acute acalculous cholecystitis is associated with high morbidity and mortality); symptoms may include abdominal pain/tenderness, fever, nausea, vomiting, leukocytosis, and abnormal liver enzymes. Evaluate and treat promptly if acute acalculous cholecystitis is suspected or diagnosed.
• GI adverse effects: Immune-mediated colitis has occurred, including a severe and acute-onset form of colitis; some cases required hospitalization and/or systemic corticosteroids. Onset ranged from a few months to years from alemtuzumab initiation.
• Hemophagocytic lymphohistiocytosis: Hemophagocytic lymphohistiocytosis (HLH), a life-threatening immune system reaction, has been reported with alemtuzumab use and is associated with high mortality rates if not treated early; it is characterized by clinical signs and symptoms of extreme systemic inflammation. Symptoms may include fever, rash, hepatosplenomegaly, lymphadenopathy, neurologic symptoms, cytopenias, elevated serum ferritin, hypertriglyceridemia, and liver function and coagulation abnormalities. Symptoms of HLH have been reported to occur up to 33 months following initiation of treatment.
• Hemophilia: Acquired hemophilia A (anti-factor VIII antibodies) has been reported. Symptoms have included spontaneous subcutaneous hematomas and extensive bruising; epistaxis, GI bleeding, hematuria, and other types of bleeding may also occur. Coagulopathy panel including aPTT should be obtained if acquired hemophilia is suspected. Patients should seek medical attention for signs and symptoms of acquired hemophilia A.
• Hepatitis: Autoimmune hepatitis causing clinically significant liver injury, including acute liver failure requiring transplant, has been reported; monitor serum transaminases and total bilirubin prior to initiation of therapy, then periodically until 48 months after the last infusion or at any time during therapy.
• Infections: Severe and prolonged lymphopenia may occur; CD4+ counts usually return to ≥200 cells/mm3 within 2 to 6 months; however, CD4+ and CD8+ lymphocyte counts may not return to baseline levels for more than 1 year. For patients being treated for MS, initiate antiviral prophylaxis (for herpetic viral infections) beginning on the first day of treatment and continue for at least 2 months or until CD4+ lymphocyte count is ≥200/mm3. In clinical trials for MS, infections seen more commonly in alemtuzumab-treated patients included nasopharyngitis, urinary tract infection, upper respiratory tract infection, sinusitis, herpetic infections, influenza, and bronchitis; serious cases of appendicitis, gastroenteritis, pneumonia, herpes zoster, and tooth infection also occurred. Serious (sometimes fatal) opportunistic infections have been reported, including aspergillosis, coccidioidomycosis, histoplasmosis, Pneumocystis jirovecii pneumonia, nocardiosis, Epstein-Barr virus, and cytomegalovirus. Listeria monocytogenes infections (encephalitis, gastroenteritis, meningitis, sepsis), including fatal cases of Listeria meningoencephalitis have been reported; Listeria infections have developed as early as 3 days post treatment and up to 8 months after the last dose for MS. The duration of increased risk for Listeria infections after treatment is unknown. Patients should initiate Listeria precautions prior to starting treatment, which include avoiding or adequately heating foods that may potentially carry this bacteria (eg, deli meat, dairy products made with unpasteurized milk, soft cheeses, or undercooked meat, seafood, or poultry). The incubation period for Listeria monocytogenes ranges from 3 to 70 days; signs/symptoms of invasive listeriosis generally start within 1 month of exposure. Symptoms of Listeria infection include fever, chills, diarrhea, nausea, vomiting, headache, pains in joints and muscles, neck stiffness, difficulty walking, mental status changes, coma, and other neurologic changes. Treatment (eg, with anti-infectives) may not adequately prevent Listeria infection-related morbidity/mortality. Epstein-Barr virus (EBV), including severe and fatal EBV-associated hepatitis, has been reported; monitor for signs and symptoms of EBV infection. Consider delaying treatment in patients with any active infection or EBV reactivation until infection is controlled. In high-risk populations or in countries with high tuberculosis burden, screen for latent infections (eg, hepatitis, tuberculosis) prior to initiating therapy. For patients who screen positive for latent infections, consult infectious disease or other specialists (eg, liver specialists) regarding treatment options before initiating therapy (AAN [Farez 2019]). Patients should be screened for human papilloma virus as clinically necessary.
• Infusion reactions: In patients treated for B-CLL, infusion reaction symptoms may include acute respiratory distress syndrome, anaphylactic/anaphylactoid shock, angioedema, bronchospasm, cardiac arrest, cardiac arrhythmias, chills, dyspnea, fever, hypotension, myocardial infarction, pulmonary infiltrates, rash, rigors, syncope, or urticaria. The incidence of infusion reaction is highest during the first week of B-CLL treatment. Premedicate with acetaminophen and an oral antihistamine. Medications for the treatment of reactions should be available for immediate use. Use caution and carefully monitor blood pressure in patients with ischemic heart disease and patients on antihypertensive therapy. For B-CLL, reinitiate with gradual dose escalation if treatment is withheld ≥7 days. Similar infusion reactions, as well as pulmonary alveolar hemorrhage, myocardial ischemia, myocardial infarction, cervicocephalic (eg, vertebral, carotid) arterial dissection, and life-threatening stroke (including ischemic and hemorrhagic stroke), have been observed with use in the treatment of multiple sclerosis; most cases occurred within 1 to 3 days. Cases of severe (including fatal) neutropenia have also been reported within 2 months of infusion; may resolve with granulocyte colony-stimulating factor treatment. Mild to moderate decreases in platelet counts at infusion initiation have been reported; may resolve without treatment. Premedication with corticosteroids for initial 3 days of each treatment course is recommended. Antihistamines and/or antipyretics may also be considered. Consider additional monitoring in patients with existing cardiovascular or respiratory compromise. Observe for infusion-related reactions; advise patients to monitor for signs/symptoms of infusion reaction, particularly during the 48 hours following infusion.
• Malignancy: Other malignant neoplasm (breast cancer or basal cell carcinoma) has been observed (rarely) in patients receiving treatment for MS. Use caution if initiating treatment in patients with preexisting or ongoing malignancies.
• Pneumonitis: Pneumonitis (hypersensitivity or fibrosis) has been reported.
• Progressive multifocal leukoencephalopathy: Progressive multifocal leukoencephalopathy (PML) was diagnosed in a patient 2 months after the second alemtuzumab course for the treatment of MS. PML is an opportunistic viral infection of the brain caused by the John Cunningham (JC) virus and usually leads to death or severe disability. PML typically only occurs in patients who are immunocompromised; however, the patient who developed PML while taking alemtuzumab had no identifiable systemic medical condition resulting in immunosuppression, had not received other MS medications for >1 year, was not taking any concomitant immunomodulatory or immunosuppressant medications, and had not previously been treated with natalizumab. Symptoms may progress over days to weeks and may include progressive weakness on one side of the body or clumsiness of limbs, vision disturbances, and mental status changes. Cases of PML have been diagnosed based on MRI findings and the detection of JC virus DNA in the cerebrospinal fluid without specific PML signs/symptoms.
• Stroke and cervicocephalic arterial dissection (Lemtrada): Most cases of stroke occurred within 1 day of administration; cases of cervicocephalic (eg, vertebral, carotid) arterial dissection involving multiple arteries occurred within 3 days. Educate patients to seek immediate medical care if symptoms of stroke and cervicocephalic arterial dissection occur.
• Thrombotic thrombocytopenic purpura: TTP has been reported, and cases may include thrombocytopenia, microangiopathic hemolytic anemia, neurological symptoms, fever, and kidney impairment.
• Thyroid disorders: Autoimmune thyroid disorders occurred in over one-third of patients receiving alemtuzumab for MS. In a trial evaluating alemtuzumab versus interferon beta-1a in patients with MS, thyroid dysfunction occurred more frequently in patients taking alemtuzumab (34% versus 6.5%) (Daniels 2014). The incidence of the first episode of thyroid dysfunction increased annually the first 3 years (year 1: 4.6%; year 2: 13.3%; year 3: 16.1%) then gradually decreased thereafter. Among patients with alemtuzumab-related thyroid dysfunction, Graves hyperthyroidism occurred most commonly (23%), followed by hypothyroidism and subacute thyroiditis (7% and 4%, respectively). Thyroid dysfunction (thyroiditis, Graves disease, goiter) has also been reported with alemtuzumab use for the treatment of other conditions.
Dosage form specific issues:
• Polysorbate 80: Some dosage forms may contain polysorbate 80 (also known as Tweens). Hypersensitivity reactions, usually a delayed reaction, have been reported following exposure to pharmaceutical products containing polysorbate 80 in certain individuals (Isaksson 2002; Lucente 2000; Shelley 1995). Thrombocytopenia, ascites, pulmonary deterioration, and renal and hepatic failure have been reported in premature neonates after receiving parenteral products containing polysorbate 80 (Alade 1986; CDC 1984). See manufacturer's labeling.
Other warnings/precautions:
• Appropriate use: Alemtuzumab is not recommended for use in patients with MS with inactive disease or who are stable on other treatment. Patients should commit to at least 48 months of follow-up after the last infusion.
• Duplicate therapy: If considering Lemtrada treatment for use in a patient who has previously received Campath/MabCampath, consider the additive and long-lasting immune system effects.
• Immunizations: In the oncology setting, patients should not be immunized with live, viral vaccines during or recently after treatment. When using for the treatment of multiple sclerosis (MS), complete necessary immunizations at least 6 weeks prior to initiating alemtuzumab. Avoid live-attenuated vaccines in patients who currently receive or have recently discontinued alemtuzumab for MS; consider using live-attenuated vaccines only if risk of infection is high and killed vaccines are unavailable (AAN [Farez 2019]). The ability to respond to any vaccine following therapy is unknown. Testing for antibodies to varicella zoster virus (VZV) is recommended prior to initiation of alemtuzumab for non-oncology purposes if history of chickenpox or VZV vaccination status is unknown; consider vaccinations for antibody-negative patients and postpone alemtuzumab treatment for 6 weeks following VZV vaccination.
• REMS Program: Prescribers and pharmacies must be certified with the REMS program, and patients and healthcare facilities must be enrolled and comply with ongoing monitoring.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, Intravenous [preservative free]:
Lemtrada: 12 mg/1.2 mL (1.2 mL) [contains edetate (edta) disodium dihydrate, polysorbate 80]
No
Solution (Lemtrada Intravenous)
12 mg/1.2 mL (per mL): $29,449.74
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, Intravenous:
Lemtrada: 12 mg/1.2 mL (1.2 mL) [contains edetate (edta) disodium dihydrate, polysorbate 80]
MabCampath: 30 mg/mL (1 mL) [contains edetate (edta) disodium dihydrate, polysorbate 80]
Campath is no longer commercially available in the United States; a restricted distribution program will allow access for appropriate patients. Information on necessary documentation and requirements is available from Clinigen Direct (1-877-768-4303) or https://www.clinigengroup.com/direct/en-gb/contact-us/#address-13.
IV: Campath or MabCampath [Canadian product]: Administer by IV infusion over 2 hours. Premedicate with diphenhydramine 50 mg and acetaminophen 500 to 1,000 mg 30 minutes before each infusion. IV glucocorticoids have been effective in decreasing severe infusion-related events. Start anti-infective prophylaxis. Other medications should not be added to or simultaneously infused through the same IV line. Do not give IV push or bolus. Compatible in polyvinylchloride (PVC) or polyethylene lined administration sets or low protein binding filters. May be given through peripheral IV.
Infusion times may have varied in studies for off-label uses; refer to specific reference citations.
Lemtrada: Administer by IV infusion over 4 hours (beginning within 8 hours after dilution); do not administer by IV push or IV bolus. May extend the infusion duration if clinically indicated. Do not infuse other medications through the same IV line. Premedicate with corticosteroids (methylprednisolone 1,000 mg or equivalent) for first 3 days of each treatment course. Administer in a setting with personnel and equipment appropriate to manage infusion reactions. Monitor vital signs prior to and periodically during the infusion. Infusion reactions should be managed symptomatically; consider discontinuing immediately for severe infusion reaction. Observe for at least 2 hours after each infusion, longer if clinically indicated.
SUBQ: Campath: SUBQ (off-label route): SUBQ administration has been studied (Ref); an increased rate of injection site reactions has been observed, with only rare incidences of chills or infusion-like reactions typically observed with IV infusion. A longer dose escalation time (1 to 2 weeks) may be needed due to injection site reactions (Lundin 2002). Premedicate with diphenhydramine 50 mg and acetaminophen 500 to 1,000 mg 30 minutes before dose. The subQ route should NOT be used for the treatment of T-PLL (Ref).
Alemtuzumab is associated with a moderate emetic potential in adults in the oncology setting; antiemetics may be recommended to prevent nausea and vomiting (Ref).
IV: Campath: Dilute prior to administration; begin administration within 8 hours of dilution; administer by IV infusion over 2 hours (Ref); do not give as an IV push or bolus injection. Compatible in polyvinylchloride (PVC) or polyethylene lined administration sets. Premedication with diphenhydramine and acetaminophen 30 minutes prior to infusion is recommended to help with infusion reaction. IV glucocorticoids have been effective in decreasing severe infusion-related events.
SubQ: Hemophagocytic lymphocytosis: Campath: Limited data available for subcutaneous administration (Ref). In adults, target dose was divided into 2 injection sites of 1.5 mL each (Ref). Premedicate with diphenhydramine and acetaminophen 30 minutes before dose.
An FDA-approved patient medication guide, which is available with the product information and as follows, must be dispensed with this medication:
Lemtrada: https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/103948s5192lbl.pdf#page=30
B-cell chronic lymphocytic leukemia: Campath or MabCampath [Canadian product]: Treatment (as a single agent) of B-cell chronic lymphocytic leukemia.
Multiple sclerosis, relapsing: Lemtrada: Treatment of relapsing-remitting and active secondary progressive multiple sclerosis (MS); generally reserved for patients who have had an inadequate response to ≥2 medications indicated for the treatment of MS.
Limitations of use: Alemtuzumab is not recommended for use in patients with clinically isolated syndrome due to its safety profile.
Acute graft-versus-host disease (steroid refractory) (treatment); Aplastic anemia, refractory; Autoimmune hemolytic anemia, chronic lymphocytic leukemia–induced; Hematopoietic cell transplant (allogeneic) conditioning regimen and/or graft-versus-host disease prophylaxis; Hemophagocytic lymphohistiocytosis, refractory; Mycosis fungoides/Sézary syndrome (advanced); Solid organ transplantation: Heart transplant, induction; Solid organ transplantation: Intestine transplant, induction; Solid organ transplantation: Kidney transplant, induction; Solid organ transplantation: Kidney transplant, steroid-resistant cellular rejection; Solid organ transplantation: Lung transplant, induction; Solid organ transplantation: Lung transplant, refractory rejection, treatment; Solid organ transplantation: Multivisceral transplant, induction; Solid organ transplantation: Pancreas transplant, induction; T-cell large granular lymphocytic leukemia; T-cell prolymphocytic leukemia
The Institute for Safe Medication Practices (ISMP) includes this medication among its list of drug classes (chemotherapeutic agent, parenteral and oral) which have a heightened risk of causing significant patient harm when used in error (High-Alert Medications in Acute Care, Community/Ambulatory Care, and Long-Term Care Settings).
Duplicate therapy issues: Campath and MabCampath contain alemtuzumab, which is the same ingredient contained in Lemtrada; patients receiving Lemtrada should not be treated with Campath or MabCampath.
None known.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.
5-Aminosalicylic Acid Derivatives: May increase myelosuppressive effects of Myelosuppressive Agents. Risk C: Monitor
Abrocitinib: May increase immunosuppressive effects of Immunosuppressants (Therapeutic Immunosuppressant Agents). Risk X: Avoid
Anticoagulants: Alemtuzumab may increase anticoagulant effects of Anticoagulants. Risk C: Monitor
Antithymocyte Globulin (Equine): Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase adverse/toxic effects of Antithymocyte Globulin (Equine). Specifically, these effects may be unmasked if the dose of immunosuppressive therapy is reduced. Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase immunosuppressive effects of Antithymocyte Globulin (Equine). Specifically, infections may occur with greater severity and/or atypical presentations. Risk C: Monitor
Antithyroid Agents: Myelosuppressive Agents may increase neutropenic effects of Antithyroid Agents. Risk C: Monitor
Baricitinib: Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase immunosuppressive effects of Baricitinib. Risk X: Avoid
BCG Products: Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of BCG Products. Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase adverse/toxic effects of BCG Products. Specifically, the risk of vaccine-associated infection may be increased. Risk X: Avoid
Brincidofovir: Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of Brincidofovir. Risk C: Monitor
Brivudine: May increase adverse/toxic effects of Immunosuppressants (Therapeutic Immunosuppressant Agents). Risk X: Avoid
Chikungunya Vaccine (Live): Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase adverse/toxic effects of Chikungunya Vaccine (Live). Specifically, the risk of vaccine-associated infection may be increased. Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of Chikungunya Vaccine (Live). Risk X: Avoid
Chloramphenicol (Ophthalmic): May increase adverse/toxic effects of Myelosuppressive Agents. Risk C: Monitor
Chloramphenicol (Systemic): Myelosuppressive Agents may increase myelosuppressive effects of Chloramphenicol (Systemic). Risk X: Avoid
Cladribine: Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase immunosuppressive effects of Cladribine. Risk X: Avoid
CloZAPine: Myelosuppressive Agents may increase adverse/toxic effects of CloZAPine. Specifically, the risk for neutropenia may be increased. Risk C: Monitor
Coccidioides immitis Skin Test: Coadministration of Immunosuppressants (Therapeutic Immunosuppressant Agents) and Coccidioides immitis Skin Test may alter diagnostic results. Management: Consider discontinuing therapeutic immunosuppressants several weeks prior to coccidioides immitis skin antigen testing to increase the likelihood of accurate diagnostic results. Risk D: Consider Therapy Modification
COVID-19 Vaccine (Inactivated Virus): Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of COVID-19 Vaccine (Inactivated Virus). Risk C: Monitor
COVID-19 Vaccine (mRNA): Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of COVID-19 Vaccine (mRNA). Management: Give a 3-dose primary series for all patients aged 6 months and older taking immunosuppressive medications or therapies. Booster doses are recommended for certain age groups. See CDC guidance for details. Risk D: Consider Therapy Modification
COVID-19 Vaccine (Subunit): Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of COVID-19 Vaccine (Subunit). Risk C: Monitor
Deferiprone: Myelosuppressive Agents may increase neutropenic effects of Deferiprone. Management: Avoid the concomitant use of deferiprone and myelosuppressive agents whenever possible. If this combination cannot be avoided, monitor the absolute neutrophil count more closely. Risk D: Consider Therapy Modification
Dengue Tetravalent Vaccine (Live): Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of Dengue Tetravalent Vaccine (Live). Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase adverse/toxic effects of Dengue Tetravalent Vaccine (Live). Specifically, the risk of vaccine-associated infection may be increased. Risk X: Avoid
Deucravacitinib: May increase immunosuppressive effects of Immunosuppressants (Therapeutic Immunosuppressant Agents). Risk X: Avoid
Efgartigimod Alfa: May decrease therapeutic effects of Fc Receptor-Binding Agents. Risk C: Monitor
Etrasimod: May increase immunosuppressive effects of Immunosuppressants (Therapeutic Immunosuppressant Agents). Risk X: Avoid
Fexinidazole: Myelosuppressive Agents may increase myelosuppressive effects of Fexinidazole. Risk X: Avoid
Filgotinib: May increase immunosuppressive effects of Immunosuppressants (Therapeutic Immunosuppressant Agents). Risk X: Avoid
Inebilizumab: Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase immunosuppressive effects of Inebilizumab. Risk C: Monitor
Influenza Virus Vaccines: Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of Influenza Virus Vaccines. Management: Administer influenza vaccines at least 2 weeks prior to initiating immunosuppressants if possible. If vaccination occurs less than 2 weeks prior to or during therapy, revaccinate 2 to 3 months after therapy discontinued if immune competence restored. Risk D: Consider Therapy Modification
Leflunomide: Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase immunosuppressive effects of Leflunomide. Management: Increase the frequency of chronic monitoring of platelet, white blood cell count, and hemoglobin or hematocrit to monthly, instead of every 6 to 8 weeks, if leflunomide is coadministered with immunosuppressive agents. Risk D: Consider Therapy Modification
Linezolid: May increase myelosuppressive effects of Myelosuppressive Agents. Risk C: Monitor
Mumps- Rubella- or Varicella-Containing Live Vaccines: Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of Mumps- Rubella- or Varicella-Containing Live Vaccines. Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase adverse/toxic effects of Mumps- Rubella- or Varicella-Containing Live Vaccines. Specifically, the risk of vaccine-associated infection may be increased. Risk X: Avoid
Nadofaragene Firadenovec: Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase adverse/toxic effects of Nadofaragene Firadenovec. Specifically, the risk of disseminated adenovirus infection may be increased. Risk X: Avoid
Natalizumab: Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase immunosuppressive effects of Natalizumab. Risk X: Avoid
Nipocalimab: May decrease therapeutic effects of Fc Receptor-Binding Agents. Risk C: Monitor
Ocrelizumab: Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase immunosuppressive effects of Ocrelizumab. Risk C: Monitor
Ofatumumab: Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase immunosuppressive effects of Ofatumumab. Risk C: Monitor
Olaparib: Myelosuppressive Agents may increase myelosuppressive effects of Olaparib. Risk C: Monitor
Ozanimod: Alemtuzumab may increase immunosuppressive effects of Ozanimod. Risk X: Avoid
Pidotimod: Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of Pidotimod. Risk C: Monitor
Pimecrolimus: Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase immunosuppressive effects of Pimecrolimus. Risk X: Avoid
Pneumococcal Vaccines: Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of Pneumococcal Vaccines. Risk C: Monitor
Poliovirus Vaccine (Live/Trivalent/Oral): Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of Poliovirus Vaccine (Live/Trivalent/Oral). Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase adverse/toxic effects of Poliovirus Vaccine (Live/Trivalent/Oral). Specifically, the risk of vaccine-associated infection may be increased. Risk X: Avoid
Polymethylmethacrylate: Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase hypersensitivity effects of Polymethylmethacrylate. Management: Use caution when considering use of bovine collagen-containing implants such as the polymethylmethacrylate-based Bellafill brand implant in patients who are receiving immunosuppressants. Consider use of additional skin tests prior to administration. Risk D: Consider Therapy Modification
Ponesimod: May increase immunosuppressive effects of Alemtuzumab. Risk X: Avoid
Promazine: May increase myelosuppressive effects of Myelosuppressive Agents. Risk C: Monitor
Rabies Vaccine: Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of Rabies Vaccine. Management: Complete rabies vaccination at least 2 weeks before initiation of immunosuppressant therapy if possible. If combined, check for rabies antibody titers, and if vaccination is for post exposure prophylaxis, administer a 5th dose of the vaccine. Risk D: Consider Therapy Modification
Ritlecitinib: Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase immunosuppressive effects of Ritlecitinib. Risk X: Avoid
Ropeginterferon Alfa-2b: Myelosuppressive Agents may increase myelosuppressive effects of Ropeginterferon Alfa-2b. Management: Avoid coadministration of ropeginterferon alfa-2b and other myelosuppressive agents. If this combination cannot be avoided, monitor patients for excessive myelosuppressive effects. Risk D: Consider Therapy Modification
Rozanolixizumab: May decrease therapeutic effects of Fc Receptor-Binding Agents. Risk C: Monitor
Ruxolitinib (Topical): Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase immunosuppressive effects of Ruxolitinib (Topical). Risk X: Avoid
Siponimod: Alemtuzumab may increase immunosuppressive effects of Siponimod. Risk X: Avoid
Sipuleucel-T: Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of Sipuleucel-T. Management: Consider reducing the dose or discontinuing the use of immunosuppressants prior to initiating sipuleucel-T therapy. Risk D: Consider Therapy Modification
Sphingosine 1-Phosphate (S1P) Receptor Modulators: May increase immunosuppressive effects of Immunosuppressants (Therapeutic Immunosuppressant Agents). Risk C: Monitor
Tacrolimus (Topical): Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase immunosuppressive effects of Tacrolimus (Topical). Risk X: Avoid
Talimogene Laherparepvec: Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase adverse/toxic effects of Talimogene Laherparepvec. Specifically, the risk of infection from the live, attenuated herpes simplex virus contained in talimogene laherparepvec may be increased. Risk X: Avoid
Tertomotide: Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of Tertomotide. Risk X: Avoid
Tofacitinib: Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase immunosuppressive effects of Tofacitinib. Management: Coadministration of tofacitinib with potent immunosuppressants is not recommended. Use with non-biologic disease-modifying antirheumatic drugs (DMARDs) was permitted in psoriatic arthritis clinical trials. Risk X: Avoid
Typhoid Vaccine: Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of Typhoid Vaccine. Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase adverse/toxic effects of Typhoid Vaccine. Specifically, the risk of vaccine-associated infection may be increased. Risk X: Avoid
Ublituximab: Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase immunosuppressive effects of Ublituximab. Risk C: Monitor
Upadacitinib: Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase immunosuppressive effects of Upadacitinib. Risk X: Avoid
Vaccines (Live): Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of Vaccines (Live). Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase adverse/toxic effects of Vaccines (Live). Specifically, the risk of vaccine-associated infection may be increased. Risk X: Avoid
Vaccines (Non-Live/Inactivated/Non-Replicating): Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of Vaccines (Non-Live/Inactivated/Non-Replicating). Management: Give non-live/inactivated/non-replicating vaccines at least 2 weeks prior to starting immunosuppressants when possible. Patients vaccinated less than 14 days before or during therapy should be revaccinated at least 2 to 3 months after therapy is complete. Risk D: Consider Therapy Modification
Yellow Fever Vaccine: Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of Yellow Fever Vaccine. Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase adverse/toxic effects of Yellow Fever Vaccine. Specifically, the risk of vaccine-associated infection may be increased. Risk X: Avoid
Zoster Vaccine (Live/Attenuated): Immunosuppressants (Therapeutic Immunosuppressant Agents) may increase adverse/toxic effects of Zoster Vaccine (Live/Attenuated). Specifically, the risk of vaccine-associated infection may be increased. Immunosuppressants (Therapeutic Immunosuppressant Agents) may decrease therapeutic effects of Zoster Vaccine (Live/Attenuated). Risk X: Avoid
Evaluate pregnancy status prior to using Campath in patients who may become pregnant.
Patients who could become pregnant should use effective contraception during therapy and for at least 3 months after the last dose of Campath. Patients who could become pregnant should use effective contraception during therapy and for 4 months after the last dose of Lemtrada.
In general, disease-modifying therapies for multiple sclerosis are stopped prior to a planned pregnancy except in females at high risk of multiple sclerosis activity (AAN [Rae-Grant 2018]). Consider use of agents other than alemtuzumab for patients at high risk of disease reactivation who are planning to become pregnant. Delaying pregnancy is recommended for patients with persistent high disease activity; however, use of alemtuzumab may be an alternative option in these patients if the last infusion is at least 4 months prior to conception (ECTRIMS/EAN [Montalban 2018]).
Patients requiring alemtuzumab for multiple sclerosis and desiring pregnancy should have thyroid function testing prior conception and be euthyroid before attempting to become pregnant (Decallonne 2018; Hammerstad 2021).
Alemtuzumab is a humanized monoclonal antibody (IgG1). Human IgG crosses the placenta. Fetal exposure is dependent upon the IgG subclass, maternal serum concentrations, placental integrity, newborn birth weight, and GA, generally increasing as pregnancy progresses. The lowest exposure would be expected during the period of organogenesis and the highest during the third trimester (Clements 2020; Palmeira 2012; Pentsuk 2009).
Outcome data following use of alemtuzumab in pregnant patients with multiple sclerosis are available (Alroughani 2016; Oh 2020; Tuohy 2015; Valeria 2021).
Alemtuzumab administration may result in the formation of autoantibodies, which may cross the placenta. A case report describes the development of maternal Graves disease following alemtuzumab therapy with placental transfer of anti-thyroid antibodies resulting in neonatal Graves disease. The patient became pregnant 8 months after a third dose of alemtuzumab for the treatment of multiple sclerosis. Maternal thyrotropin receptor stimulating antibodies (TRAb) were slightly elevated at conception and increased significantly during pregnancy. TRAb levels were also significantly elevated in the infant at birth. Symptoms of thyrotoxicosis were observed at 10 days of age in the newborn; thyroid function tests returned to normal after 3 weeks of treatment and normal growth and development were reported at 3 months of age (Hammerstad 2022). Thyroid disorders induced by alemtuzumab therapy may cause adverse maternal and fetal events.
In general, disease-modifying therapies for multiple sclerosis are not initiated during pregnancy, except in patients at high risk of multiple sclerosis activity (AAN [Rae-Grant 2018]).
Data collection to monitor pregnancy and infant outcomes following exposure to alemtuzumab is ongoing. Health care providers are encouraged to enroll patients exposed to alemtuzumab during pregnancy in the pregnancy exposure registry (1-800-745-4447, option 2).
It is not known if alemtuzumab is present in breast milk.
Alemtuzumab is a humanized monoclonal antibody (IgG1). Human IgG is present in breast milk; concentrations are dependent upon IgG subclass and postpartum age (Anderson 2021).
According to the manufacturer, the decision to breastfeed during Lemtrada therapy should consider the risk of infant exposure, the benefits of breastfeeding to the infant, benefits of treatment to the mother, and the long half-life of alemtuzumab. Other sources do not recommend breastfeeding during therapy (Dobson 2019; Fragoso 2018). Due to the potential for adverse reactions, including reduced lymphocyte counts in a breastfed child, the manufacturer does not recommend breastfeeding during Campath therapy or for at least 3 months after the last Campath dose.
Campath: CBC with differential and platelets (weekly, more frequent if worsening); signs and symptoms of infection; CD4+ lymphocyte counts (after treatment until recovery); cytomegalovirus antigen (routinely during and for 2 months after treatment); consider thyroid-stimulating hormone (TSH) at baseline and then every 2 to 3 months during alemtuzumab treatment (Hamnvik 2011). Monitor closely for infusion reactions (including hypotension, rigors, fever, shortness of breath, bronchospasm, chills, and/or rash); vital signs (prior to and during infusion); carefully monitor BP, especially in patients with ischemic heart disease or on antihypertensive medications. Advise patients to monitor for signs/symptoms of infusion reaction, particularly during the 48 hours following infusion. The American Society of Clinical Oncology hepatitis B virus (HBV) screening and management provisional clinical opinion (ASCO [Hwang 2020]) recommends HBV screening with hepatitis B surface antigen, hepatitis B core antibody, total Ig or IgG, and antibody to hepatitis B surface antigen prior to beginning (or at the beginning of) systemic anticancer therapy; do not delay treatment for screening/results. Detection of chronic or past HBV infection requires a risk assessment to determine antiviral prophylaxis requirements, monitoring, and follow-up. Evaluate pregnancy status prior to use in patients who could become pregnant. Monitor for signs/symptoms of infection; monitor for cytomegalovirus infection (during and for at least 2 months after completion of therapy). Monitor for signs/symptoms of autoimmune anemia or autoimmune thrombocytopenia. Monitor for signs/symptoms of hepatic dysfunction (unexplained nausea, vomiting, abdominal pain, anorexia, fatigue, jaundice, and/or dark urine). Monitor for signs/symptoms of pneumonitis (dyspnea, cough, wheezing, hemoptysis, chest pain/tightness). Monitoring with brain MRI for signs that may be consistent with progressive multifocal leukoencephalopathy (PML) may be beneficial and allow for an early diagnosis of PML. Monitor for signs/symptoms of immune-mediated colitis (new or persistent diarrhea, other GI symptoms).
Lemtrada: CBC with differential prior to initiation then monthly until 48 months after last infusion; serum creatinine prior to initiation then monthly until 48 months after last infusion or at any time during therapy if clinically indicated; serum transaminases and total bilirubin prior to initiation then periodically until 48 months after the last infusion or at any time during therapy if clinically indicated; urinalysis with urine cell counts prior to initiation then monthly until 48 months after last infusion (urine dipstick results of ≥1+ protein warrant assessment of urine protein to creatinine ratio); urine protein to creatinine ratio at baseline and then as clinically indicated (evaluate further for nephropathies if urine protein to creatinine ratio >200 mg/g, increase in serum creatinine >30%, or unexplained hematuria); ECG at baseline; TSH at baseline and every 3 months until 48 months after last infusion or longer or at any time during therapy if clinically indicated or in case of pregnancy; coagulopathy panel, including aPTT, in patients presenting with signs of acquired hemophilia A. Observe for at least 2 hours after each infusion, longer if clinically indicated. Monitor for signs/symptoms of infection; annual human papillomavirus screening; latent infection screening (eg, hepatitis, tuberculosis) in high-risk populations or in countries with high tuberculosis burden (baseline); signs/symptoms of progressive multifocal leukoencephalopathy and hemophagocytic lymphohistiocytosis; signs/symptoms of thrombotic thrombocytopenic purpura; signs/symptoms of autoimmune encephalitis; signs/symptoms of immune thrombocytopenia (easy bruising, petechiae, spontaneous mucocutaneous bleeding, heavy menstrual bleeding); signs/symptoms of nephropathy (dyspnea, edema, elevated serum creatinine, change in urine color, decreased urine output, fatigue, hematuria, hemoptysis, proteinuria); signs/symptoms of hepatic dysfunction (unexplained nausea, vomiting, abdominal pain, anorexia, fatigue, jaundice, and/or dark urine); signs/symptoms of pneumonitis (dyspnea, cough, wheezing, hemoptysis, chest pain/tightness); monitoring with brain MRI for signs that may be consistent with PML may be beneficial and allow for an early diagnosis of PML; signs/symptoms of immune-mediated colitis (new or persistent diarrhea, other GI symptoms); baseline and annual skin exams (for melanoma).
Alemtuzumab binds to CD52, a nonmodulating antigen present on the surface of B and T lymphocytes, a majority of monocytes, macrophages, NK cells, and a subpopulation of granulocytes. After binding to CD52+ cells, an antibody-dependent lysis of malignant cells occurs. In multiple sclerosis, alemtuzumab immunomodulatory effects may include alteration in the number, proportions, and properties of some lymphocyte subsets following treatment.
Distribution: Vd: IV: Campath: 0.18 L/kg (range: 0.1 to 0.4 L/kg); Lemtrada: 14.1 L
Metabolism: Campath: Clearance decreases with repeated dosing (due to loss of CD52 receptors in periphery), resulting in a sevenfold increase in AUC after 12 weeks of therapy.
Half-life elimination: IV: Campath: 11 hours (following first 30 mg dose; range: 2 to 32 hours); 6 days (following the last 30 mg dose; range: 1 to 14 days); Lemtrada: ~2 weeks
