Nature of operation | Common pathogens | Recommended antimicrobials | Usual adult dose*[1] | Redose interval¶ [2] |
Cystoscopy alone | Enteric gram-negative bacilli, enterococci | High-riskΔ only: ciprofloxacin◊ | 500 mg orally or 400 mg IV | N/A |
OR trimethoprim-sulfamethoxazole | One 160/800 mg (double strength, DS) tablet orally | N/A | ||
Cystoscopy with manipulation (eg, transrectal prostate biopsy) or upper tract instrumentation (eg, ureteroscopy, shock wave lithotripsy) | Enteric gram-negative bacilli, enterococci | Ciprofloxacin◊ | 500 mg orally or 400 mg IV | N/A |
OR trimethoprim-sulfamethoxazole | One 160/800 mg (double strength, DS) tablet orally | N/A | ||
Open or laparoscopic surgery§ | Enteric gram-negative bacilli, enterococci | Cefazolin¥ | <120 kg: 2 g IV ≥120 kg: 3 g IV | 4 hours |
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