Outcomes | Number of participants (studies), follow-up | Certainty of the evidence (GRADE) | Relative effect (95% CI) | Anticipated absolute effects over 10 years | |
Risk with placebo | Risk difference with aspirin* | ||||
Total mortality Follow-up: range 3.8 to 10 years[1-4] | 161,660 (13 RCTs) | ⊕⊕⊕ MODERATE due to imprecision¶ | RR 0.97 (0.93 to 1.02) | 60-year-old personΔ | |
83 per 1000Δ | 2 fewer per 1000 (6 fewer to 2 more) | ||||
Myocardial infarction (MI) Nonfatal events Follow-up: range 3.8 to 10 years[1,2,4] | 142,566 (12 RCTs) | ⊕⊕⊕⊕ HIGH | RR 0.83 (0.76 to 0.90) | Low cardiovascular risk population◊ | |
27 per 1000§ | 5 fewer per 1000 (6 fewer to 3 fewer) | ||||
Moderate cardiovascular risk population◊ | |||||
83 per 1000§ | 14 fewer per 1000 (20 fewer to 8 fewer) | ||||
High cardiovascular risk population◊ | |||||
136 per 1000§ | 23 fewer per 1000 (33 fewer to 14 fewer) | ||||
Stroke Includes nonfatal ischemic and hemorrhagic strokes Follow-up: range 3.8 to 10 years[1,2,4] | 127,433 (12 RCTs) | ⊕⊕⊕ MODERATE due to imprecision¶ | RR 0.95 (0.85 to 1.06) | Low cardiovascular risk population◊ | |
23 per 1000§ | 1 fewer per 1000 (3 fewer to 1 more) | ||||
Moderate cardiovascular risk population◊ | |||||
65 per 1000§ | 3 fewer per 1000 (10 fewer to 4 more) | ||||
High cardiovascular risk population◊ | |||||
108 per 1000 | 5 fewer per 1000 (16 fewer to 6 more) | ||||
Major extracranial bleed¶¶ Follow-up: range 3.8 to 10 years[1,2,4-6] | 155,911 (11 RCTs) | ⊕⊕⊕⊕ HIGH | RR 1.46 (1.32 to 1.62) | Low cardiovascular risk population‡ | |
8 per 1000§ | 4 more per 1000 (3 more to 5 more) | ||||
Moderate cardiovascular risk population‡ | |||||
24 per 1000§ | 11 more per 1000 (8 more to 15 more) | ||||
High cardiovascular risk population‡ | |||||
40 per 1000§ | 18 more per 1000 (13 more to 25 more) | ||||
Colorectal cancer (incidence) Follow-up: median 18.3 years[7] | 14,033 (4 RCTs) | ⊕⊕ LOW due to imprecision† and risk of biasΔΔ | HR 0.76 (0.60 to 0.96) | Low colorectal cancer risk population: Anticipated absolute effect over 20 years◊◊ | |
30 per 1000** | 7 fewer per 1000 (12 fewer to 1 fewer) | ||||
Moderate colorectal cancer risk population | |||||
53 per 1000** | 12 fewer per 1000 (21 fewer to 2 fewer) | ||||
High colorectal cancer risk population | |||||
100 per 1000** | 23 fewer per 1000 (39 fewer to 4 fewer) |
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