Fixed drug eruption (FDE): Lesion reactivation upon challenge with the causative drug

Typical resting hyperpigmented FDE lesions before and after clinical challenge with the causative drug: erythematous macules develop only in the pigmented lesions. The surrounding skin is unaffected.

Reproduced with permission from: Shiohara T, Mizukawa Y. Fixed drug eruption: a disease mediated by self-inflicted responses of intraepidermal T cells. Eur J Dermatol 2007; 17:201. Copyright © 2007 John Libbey Eurotext. All rights reserved.

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Fixed drug eruption (FDE): Lesion reactivation upon challenge with the causative drug