Histologic features of fixed drug eruption

(A) A small number of lymphocytes adhering to the epidermis seen in the resting lesional skin (H & E stain; ×66).
(B) Absence of lymphocytes in the epidermis of the adjacent uninvolved perilesional skin (H & E stain; x66).

Reproduced with permission from: Shiohara T, Mizukawa Y. Fixed drug eruption: a disease mediated by self-inflicted responses of intraepidermal T cells. Eur J Dermatol 2007; 17:201. Copyright © 2007 John Libbey Eurotext. All rights reserved.

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Histologic features of fixed drug eruption