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خرید پکیج

تعداد آیتم قابل مشاهده باقیمانده : 3 مورد

Clinical and laboratory features of severe drug eruptions

Clinical and laboratory features of severe drug eruptions

Syndrome	Rash morphology	Localization	Timing	Internal organ involvement	Systemic signs	Laboratory findings
DRESS	Maculopapular exanthem Erythroderma Facial edema Purpura, pustules	Generalized Mucosal involvement infrequent	2 to 6 weeks	Lymphadenopathy Hepatitis Pneumonitis Nephritis Thyroiditis Myocarditis Eosinophilia	Fever (>38°C/100.4°F) Malaise Fatigue	Eosinophilia, atypical lymphocytes Abnormal liver, renal function tests
AGEP	Intertriginous erythema, maculopapular exanthem, widespread nonfollicular pinpoint pustules	Generalized, rarely flexural Mucosal involvement rare	1 to 11 days	Liver, renal, pulmonary may be involved but generally mild	Fever (>38°C/100.4°F)	Leukocytosis with neutrophilia (>7000/mm³)
SJS/TEN	Dusky red confluent erythema, atypical target lesions, purpura, blisters, and sheet-like detachment Nikolsky sign is positive SJS <10%, SJS/TEN 10 to 30%, TEN >30%	Disseminated Mucosal involvement nearly in all cases	4 to 28 days	Pneumonitis, hepatitis, acute renal failure, GI, leucopenia	Fever (>38°C/100.4°F) Malaise Fatigue Sore throat Dysphagia, photophobia	Lymphopenia Epidermal necrosis on skin biopsy with full thickness loss of epidermis

AGEP: acute generalized exanthematous pustulosis; DRESS: drug reaction with eosinophilia and systemic symptoms; GI: gastrointestinal; SJS/TEN: Stevens-Johnson syndrome/toxic epidermal necrolysis.

Adapted from:

Scherer K, Bircher A. Adverse drug reactions and the skin--from trivial to fire signal. Internist (Berl) 2009; 50:171.
Bircher AJ, Scherer K. Delayed cutaneous manifestations of drug hypersensitivity. Med Clin North Am 2010; 94:711.
Duong TA, Valeyrie-Allanore L, Wolkenstein P, Chosidow O. Severe cutaneous adverse reactions to drugs. Lancet 2017; 390:1996.

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