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Mantle cell lymphoma international prognostic index (MIPI)

Mantle cell lymphoma international prognostic index (MIPI)
Points Age (years) ECOG performance status LDH:ULN ratio WBC (109/L)
0 <50 0 to 1 <0.67 <6.7
1 50 to 59   0.67 to 0.99 6.7 to 9.9
2 60 to 69 2 to 4 1.00 to 1.49 10.0 to 14.9
3 ≥70   ≥1.50 ≥15.00
One to three points is given for each of the above characteristics present in the patient with MCL, for a total score ranging from zero to 12. When applied to a study of long term survival in 455 patients with MCL diagnosed between 1996 and 2004, the following three risk groups and their corresponding median and five-year survivals were as follows:
Score Risk group Median survival Five-year OS
0 to 3 points Low risk Not reached 60 percent
4 to 5 points Intermediate risk 58 months 35 percent
6 to 12 points High risk 37 months 20 percent
ECOG: Eastern Cooperative Oncology Group; LDH: lactate dehydrogenase; ULN: upper limit of normal; WBC: white blood cells; MCL: mantle cell lymphoma; OS: overall survival.
This research was originally published in Blood. Modified from: Hoster E, Dreyling M, Klapper W, et al. A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma. Blood 2008; 111:558. Copyright © 2008 American Society of Hematology.
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