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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
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Clinical manifestations and chronology of cutaneous drug reactions

Clinical manifestations and chronology of cutaneous drug reactions
Clinical manifestation Chronology Morphology and localization
Urticaria
  • Immediate
  • Minutes to 2 hours
  • Rapid change and resolution of single lesions (<24 hours)
  • Urticarial wheals, pale swelling surrounded by erythematous border
  • Pruritus
  • Trunk, face, mucosae, or generalized
Angioedema
  • Immediate to delayed
  • Minutes up to 6 hours
  • Resolution 24 to 72 hours
  • Pale swelling
  • Dysesthesia, pain
  • Face, lips, eye lids, mucosa, male genitals
Maculopapular exanthem
  • Delayed
  • Typically 6 to 24 hours
  • Peak at 48 to 72 hours
  • Resolution 1 week
  • Macules, papules
  • Confluence, desquamation
  • Trunk, proximal extremities, or disseminated
Fixed drug eruption
  • Delayed
  • Typically 30 minutes to 8 hours
  • Resolution 7 to 10 days
  • Erythematous or lilac macule or plaque, central bulla/erosion, permanent hyperpigmentation, burning, pruritus
  • Fixed (identical site)
  • Acral or mucosal localization
Pustular exanthem (AGEP)
  • Delayed
  • Typically 6 to 12 hours up to 48 hours
  • Resolution 1 week
  • Confluent erythema; pinpoint, nonfollicular pustules; pruritus; massive desquamation
  • Folds, trunk, or generalized
Vesicobullous exanthems
  • Delayed
  • Typically 24 to 48 hours
  • Resolution several weeks
  • Macules, bullae, epidermolysis, mucositis
  • Initially painful skin
  • Trunk, face, or generalized
AGEP: acute generalized exanthematous pustulosis.
Original table modified for this publication. Bircher AJ, Scherer K. Delayed cutaneous manifestations of drug hypersensitivity. Med Clin North Am 2010; 94:711. Table used with the permission of Elsevier Inc. All rights reserved.
Graphic 86515 Version 3.0

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