Version May 2024
| Entity | Histology | Immunophenotype | Genetic features/other |
| Follicular lymphoma | Nodular growth pattern of follicle center cells (centrocytes and centroblasts). Tingible body macrophages usually absent. | Typically express CD10, HLA-DR, pan B-cell antigens (CD19, CD20, CD79a), CD21, and surface IgM, IgG, or IgA. Ki-67 low. Cytoplasmic staining for BCL-2 protein is strongly positive in almost all grade I/II follicular lymphoma tumors | No single chromosomal change is diagnostic. t(14;18) present in 85 percent. Abnormalities in 3q27 present in 5 to 15 percent. |
| Reactive follicular hyperplasia | Discrete follicles of varying sizes and shapes are separated from one another by interfollicular regions rich in T cells within the lymph node cortex. Prominent tingible body macrophages. | Typically express CD10, HLA-DR, pan B-cell antigens (CD19, CD20, CD79a), CD21, and surface IgM, IgG, or IgA. Ki-67 high BCL-2 negative | No specific genetic features |
| Mantle cell lymphoma | Monomorphous small to medium-sized B lymphocytes with irregular nuclei. No proliferation centers. | CD5+ and CD10– The vast majority overexpress cyclin D1 | t(11;14) |
| Diffuse large B cell lymphoma: T cell rich large B cell lymphoma subtype | Infiltrating small cells (reactive T cells) are present with interspersed larger cells that resemble centroblasts | Larger neoplastic cells express pan B-cell antigens (CD19, CD20, CD79a), and monoclonal surface membrane IgM. Smaller cells are reactive and express T cell antigens. | Genetic abnormalities varied |
| Marginal zone lymphoma | May have a partially nodular pattern of growth | >95 percent CD10– | Lacks t(11;14) and t(14;18) |
| Histologic transformation to diffuse large B cell lymphoma | Large, transformed B cells with prominent nucleoli and basophilic cytoplasm demonstrating a diffuse growth pattern and a high (>40 percent) proliferation fraction | Express pan B cell antigens (CD19, CD20, CD79a), CD45, and monoclonal surface membrane IgM. Some cases will demonstrate CD5. | Often t(14;18) positive; various other genetic aberrations |
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