Variants/polymorphisms that have been associated with heritable and acquired forms of amyloidosis, 2021^[1-3]

	Number of variants shown
Subunit proteins
Transthyretin (TTR)	>138
Prion protein (PrP)	>30
Alzheimer precursor protein (APP)	52
Bri2	2
Lysozyme (Lys)	11
Apolipoprotein AI (ApoAI)	22
Apolipoprotein AII (ApoAII)	4
Apolipoprotein CII (ApoCII)	2
Apolipoprotein CIII (ApoCIII)	1
Fibrinogen A-alpha	15
Gelsolin	7
Cystatin C	1
Keratoepithelin/TGF1B1	>40
Beta-2 microglobulin	1
Tumor-associated Ca signal transducer 2	21
Polymorphisms
SAA1/SAA2	5/2
Apo E4/E2
Other
Pyrin (MEFV)	>300
Cryopyrin (CIAS1)	145
TRAPS (TNFR1)	99
Mevalonate kinase (MVK)	>162
Presenilin-1 (PS-1)/presenilin-2 (PS-2)	215/15

References:

www.amyloidosismutations.com (Accessed on February 1, 2021).
https://infevers.umai-montpellier.fr/web/ (Accessed on February 1, 2021).
Alzheimer Disease & Frontotemporal Dementia Mutation Database (Accessed on February 1, 2021).

Courtesy of Peter D Gorevic, MD.

Graphic 85771 Version 6.0

Variants/polymorphisms that have been associated with heritable and acquired forms of amyloidosis, 2021[1-3]