Version May 2024
All products have been discontinued for more than 1 year.
Refer to adult dosing.
Refer to adult dosing.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
<1%, postmarketing, and/or case reports: Dermatitis, erythema, irritability, neurologic injury, seizure, skin photosensitivity, xeroderma
Hypersensitivity to halogenated phenol derivatives or hexachlorophene; use on burned or denuded skin; use as an occlusive dressing, wetpack, or lotion; application to mucous membranes; use as a vaginal pack or tampon; routine use for prophylactic total body bathing
Concerns related to adverse effects:
• Cerebral irritability: Discontinue use if signs of cerebral irritability occur.
Special populations:
• Burn patients: Exposure to patients with extensive burns has been associated with apnea, convulsions, agitation and coma.
• Pediatric: Exposure to preterm infants has been associated with apnea, convulsions, agitation and coma; particularly susceptible to hexachlorophene topical absorption. Do not use for bathing infants.
Other warnings/precautions:
• Appropriate use: For external use only; avoid exposure to eyes.
Premature and low birth weight neonates are particularly susceptible to hexachlorophene topical absorption; irritability, generalized clonic muscular contractions, decerebrate rigidity, and brain lesions in the white matter have occurred in infants following topical use of 6% hexachlorophene; exposure of preterm infants or patients with extensive burns has been associated with apnea, convulsions, agitation, and coma.
All products have been discontinued for more than 1 year.
Yes
Liquid (Phisohex External)
3% (473 mL): $61.26
Disclaimer: The pricing data provided represent a median AWP and/or AAWP price for the brand and/or generic product, respectively. The pricing data should be used for benchmarking purposes only, and as such should not be used to set or adjudicate any prices for charging or reimbursement functions. Pricing data is updated monthly.
Hazardous agent; use appropriate precautions for handling and disposal (EPA, U-listed).
Surgical scrub and as a bacteriostatic skin cleanser; control an outbreak of gram-positive infection when other procedures have been unsuccessful
pHisoHex may be confused with Fostex, pHisoDerm
KIDs List: Hexachlorophene, when used in neonates, is identified on the Key Potentially Inappropriate Drugs in Pediatrics (KIDs) list and should be avoided due to risk of neurotoxicity (strong recommendation; high quality of evidence) (PPA [Meyers 2020]).
None known.
There are no known significant interactions.
Adverse events have been observed in animal reproduction studies. Hexachlorophene is absorbed systemically when applied topically. Following use as an antiseptic for vaginal exams during labor, hexachlorophene is detectable in the maternal serum and cord blood (Strickland, 1983). Vaginal use as a pack or tampon and application to mucous membranes is contraindicated.
It is not known if hexachlorophene is excreted in breast milk. Due to the potential for serious adverse reactions in the nursing infant, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of treatment to the mother.
Bacteriostatic polychlorinated biphenyl which inhibits membrane-bound enzymes and disrupts the cell membrane
Absorption: Percutaneously through inflamed, excoriated, and intact skin
Half-life elimination: Infants: 6.1-44.2 hours
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