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تعداد آیتم قابل مشاهده باقیمانده : -8 مورد

Mechanisms for urate secretion by the proximal tubule

Mechanisms for urate secretion by the proximal tubule
Urate enters the cell at the basolateral membrane via exchange with alpha-ketoglutarate, mediated by OAT1 and OAT3. At the apical membrane, urate is secreted via ABCC4, ABCG2, NPT1, and/or NPT4.

Courtesy of David B Mount, MD, 2012.

Updated with information from:
  1. Johnson RJ, Bakris GL, Borghi C, et al. Hyperuricemia, acute and chronic kidney disease, hypertension, and cardiovascular disease: Report of a scientific workshop organized by the National Kidney Foundation. Am J Kidney Dis 2018; 71:851.
  2. Mandal AK, Mount DB. The molecular physiology of uric acid homeostasis. Annu Rev Physiol 2015; 77:323.
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