Liver biopsy in a child with indeterminate acute liver failure

Example of a liver biopsy in a child with acute liver failure of indeterminate etiology, with falling ALT (1250 IU/L to 275 IU/L), rising total bilirubin (12.5 mg/dL to 25 mg/dL), and rising prothrombin time (rising from 20 to 26 seconds). Histology reveals a dense infiltrate, dominated by lymphocytes but with scattered neutrophils and eosinophils, and with hepatic necrosis and biliary damage.
(A) Low-power view.
(B) High-power view.