Brain MRI, 1-year-old female with Canavan disease

T2-weighted (A, B) and T1-weighted (C, D) MRI of the brain showing severe and diffuse T2 hyperintense and T1 hypointense signal changes in the white matter suggesting Canavan disease. Significant involvement of U fibers is present. Multiple round or oval cystic changes within the white matter give a honeycomb appearance. The radial arrangement of these cystic spaces suggests dilatation of Virchow-Robin spaces due to spongiform degeneration of the white matter.