Liquid and capsule challenge procedures for potassium metabisulfite (sulfites)

Food additive	Route	Dose	Interval time	Monitoring
Potassium metabisulfite	Skin prick testing	0.001 mg/mL 0.01 mg/mL 0.1 mg/mL 1 mg/mL	15 minutes	Wheal/erythema
	Intradermal	0.02 mL of 0.001 mg/mL solution	15 minutes	Wheal/erythema
	Oral (solution)	1 mg, 10 mg, 25 mg, 50 mg, 100 mg	20 minutes in between doses	Spirometry prior to each dose and following each dose
	Oral (capsule)	1 mg, 10 mg, 25 mg, 50 mg, 100 mg	30 minutes in between doses	Spirometry prior to each dose and following each dose

Data from: Bush RK, Zoratti E, Taylor SL. Diagnosis of sulfite and aspirin sensitivity. Clin Rev Allergy 1990; 8:159.

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