(A) Papillary dermal interstitial infiltrate associated with linear aggregation of neoplastic lymphocytes along the dermal-epidermal junction.
(B) Adjacent section stained for CD4 emphasizing this linear pattern of early epidermotropism.
(C) Early plaque-stage disease with single cell epidermotropism by atypical lymphocytes into a "passive" epidermal layer.
(D) Plaque-stage disease characterized by prominent clusters of atypical lymphocytes within the epidermis (Pautrier microabscesses).
Reproduced with permission from: Hsu MY, Murphy GF. Cutaneous lymphomas and leukemias. In: Lever's Histopathology of the Skin, 10th ed, Elder DE, Elenitsas RE, Johnson BL Jr, et al. (Eds), Lippincott Williams & Wilkins, Philadelphia 2009. Copyright © 2009 Lippincott Williams & Wilkins.
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