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تعداد ایتم قابل مشاهده باقیمانده : 4 مورد

Ferric subsulfate: Drug information

Ferric subsulfate: Drug information
For abbreviations and symbols that may be used in Lexicomp (show table)
Brand Names: US
  • Astringyn;
  • Monsels Ferric Subsulfate
Pharmacologic Category
  • Hemostatic Agent
Dosing: Adult

Hemostasis: Topical: Apply evenly to wound

Dosing: Renal Impairment: Adult

No dosage adjustment provided in manufacturer’s labeling.

Dosing: Hepatic Impairment: Adult

No dosage adjustment provided in manufacturer’s labeling.

Dosing: Geriatric

Refer to adult dosing.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, External:

Astringyn: 259 mg/g (8 g) [contains benzalkonium chloride]

Monsels Ferric Subsulfate: (8 mL, 60 mL)

Generic Equivalent Available: US

Yes

Administration: Adult

Topical: For external use only. Apply to wound using cotton applicator/swab. Avoid contact with eyes.

Use: Labeled Indications

Hemostatic in minor surgical procedures

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Frequency not defined.

Dermatologic: Skin hyperpigmentation (application site)

Contraindications

There are no contraindications in the manufacturer’s labeling.

Warnings/Precautions

Concerns related to adverse effects:

• Hyperpigmentation: May cause heavy pigmentation at application sites, which may result in histologic artifacts (upon rebiopsy) or in radiographic artifacts.

Other warnings/precautions:

• Appropriate use: For external use only. If inadvertent ocular administration occurs wash eye(s) immediately with large amounts of water or normal saline for approximately 15 to 20 minutes or until no evidence of solution remains.

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Pregnancy Considerations

Ferric subsulfate is used as a hemostatic agent following cervical biopsies (Manca 1997; Tam 2005). May cause vaginal pain if leakage of solution occurs (Tam 2005). A case report also describes use following a miscarriage; fertility was not impaired and a successful pregnancy occurred 7 months later (Disu 2007).

Monitoring Parameters

Hemostasis at site of application.

Mechanism of Action

Causes agglutination of surface proteins resulting in hemostasis

Pharmacodynamics and Pharmacokinetics

Onset: Hemostasis: ≤20 seconds

Pricing: US

Solution (Astringyn External)

259 mg/g (per gram): $1.14

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

REFERENCES

  1. Disu S, Rebello L, and Atalla R, "The Use of Intrauterine Monsel's Solution in Severe Hemorrhage After Evacuation of Retained Products of Conception: A Case Report," Am J Obstet Gynecol, 2007, 196(2):6-7. [PubMed 17306641]
  2. Jetmore AB, Heryer JW, and Conner WE, "Monsel's Solution: A Kinder, Gentler Hemostatic," Dis Colon Rectum, 1993, 36(9):866-7. [PubMed 8375230]
  3. Manca DP, "Stopping Cervical Bleeding," Can Fam Physician, 1997, 43:2121. [PubMed 9426929]
  4. Olmstead PM, Lund HZ, and Leonard DD, "Monsel's Solution: A Histologic Nuisance," J Am Acad Dermatol, 1980, 3(5):492-8. [PubMed 7217377]
  5. Tam KF, Lee TP, and Ngan HY, "Hemostasis Following Cervical Punch Biopsy Using Monsel's Solution," Int J Gynaecol Obstet, 2005, 88(2):160-1. [PubMed 15694100]
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