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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Comparison of complement studies in angioedema disorders

Comparison of complement studies in angioedema disorders
Angioedema disorder C4* C1-INH level C1-INH function C1q Other tests
Hereditary angioedema with C1-INH deficiency type I (HAE-C1-INH
type I)		 Low Low Low
(usually <50% of normal)		 Normal Genetic testing
(not needed for diagnosis)
Hereditary angioedema with C1INH deficiency type II (HAE-C1-INH type II) Low Normal or elevated Low
(usually <50% of normal)		 Normal Genetic testing
(not needed for diagnosis)
Hereditary angioedema with factor XII gene mutations
(HAE-FXII)		 Normal Normal Normal Normal Mutations in gene for factor XII
Hereditary angioedema with angiopoietin-1 gene mutations (HAE-ANGPT1) Normal Normal Normal Normal Mutations in gene for angiopoietin-1
Hereditary angioedema with plasminogen gene mutations (HAE-PLG) Normal Normal Normal Normal Mutations in gene for plasminogen
Hereditary angioedema with kininogen-1 gene mutations (HAE-KNG1) Normal Normal Normal Normal Mutations in gene for kininogen-1
Hereditary angioedema of unknown origin (HAE-U) Normal Normal Normal Normal  
Acquired angioedema with C1-INH deficiency (AAE-C1-INH) Low Normal or low Low
(usually <50% of normal)		 Normal or low Anti-C1-INH antibodies
(not needed for diagnosis)
Idiopathic acquired angioedema
(histaminergic or nonhistaminergic)
(AAE-IH or AAE-InH)		 Normal Normal Normal Normal  
ACE inhibitor-associated angioedema (AAE-ACEI) Normal Normal Normal Normal  
Terminology for angioedema disorders is evolving, and the abbreviations HAE-C1-INH and C1INH-HAE are both used for hereditary angioedema in the literature.
C1-INH: C1 inhibitor; HAE: hereditary angioedema; AAE: acquired angioedema; ACEI: angiotensin-converting enzyme inhibitor.
* In HAE-C1-INH types I and II, C4 is always low during an attack (with one published exception) and are chronically low in the majority of patients.
¶ There are rare forms of acquired angioedema in which C1q levels are normal. Refer to the UpToDate topics on acquired C1 inhibitor deficiency for details.
Graphic 83098 Version 9.0

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